Necrotizing autoimmune myopathy: a case series
Necrotizing autoimmune myopathy (NAM) is considered a new subgroup of a rare autoimmune idiopathic inflammatory myopathies. Classically, NAM presented with sub-acute onset of proximal muscle loss of power with raised creatinine kinase and characteristic muscle biopsy showing muscle necrosis and rege...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/90297/1/13upm.pdf |
| _version_ | 1825936805171560448 |
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| author | Sulaiman Sahari, Narisa Marwan, Abdul Aziz Suahilai, Dayang Masyrinartie Mohd Jamid, Nurulraziquin Shahril, Nor Shuhaila |
| author_facet | Sulaiman Sahari, Narisa Marwan, Abdul Aziz Suahilai, Dayang Masyrinartie Mohd Jamid, Nurulraziquin Shahril, Nor Shuhaila |
| author_sort | Sulaiman Sahari, Narisa |
| collection | UPM |
| description | Necrotizing autoimmune myopathy (NAM) is considered a new subgroup of a rare autoimmune idiopathic inflammatory myopathies. Classically, NAM presented with sub-acute onset of proximal muscle loss of power with raised creatinine kinase and characteristic muscle biopsy showing muscle necrosis and regeneration with little inflammation. Statin use, connective tissue diseases, malignancy and HIV infection are the identified risk factors for NAM. The autoantibodies expected to be presented in NAM are anti-signal recognition particle (SRP) and anti-hydroxymethylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. In this article, we present three cases of NAM with different risk factors and autoantibodies which we believe to have impact on the clinical course and outcome of our patients. |
| first_indexed | 2024-03-06T10:49:52Z |
| format | Article |
| id | upm.eprints-90297 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:49:52Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-902972021-09-09T23:22:16Z http://psasir.upm.edu.my/id/eprint/90297/ Necrotizing autoimmune myopathy: a case series Sulaiman Sahari, Narisa Marwan, Abdul Aziz Suahilai, Dayang Masyrinartie Mohd Jamid, Nurulraziquin Shahril, Nor Shuhaila Necrotizing autoimmune myopathy (NAM) is considered a new subgroup of a rare autoimmune idiopathic inflammatory myopathies. Classically, NAM presented with sub-acute onset of proximal muscle loss of power with raised creatinine kinase and characteristic muscle biopsy showing muscle necrosis and regeneration with little inflammation. Statin use, connective tissue diseases, malignancy and HIV infection are the identified risk factors for NAM. The autoantibodies expected to be presented in NAM are anti-signal recognition particle (SRP) and anti-hydroxymethylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. In this article, we present three cases of NAM with different risk factors and autoantibodies which we believe to have impact on the clinical course and outcome of our patients. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-08 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90297/1/13upm.pdf Sulaiman Sahari, Narisa and Marwan, Abdul Aziz and Suahilai, Dayang Masyrinartie and Mohd Jamid, Nurulraziquin and Shahril, Nor Shuhaila (2020) Necrotizing autoimmune myopathy: a case series. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 8). pp. 78-80. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020082609350513_MJMHS_0221.pdf |
| spellingShingle | Sulaiman Sahari, Narisa Marwan, Abdul Aziz Suahilai, Dayang Masyrinartie Mohd Jamid, Nurulraziquin Shahril, Nor Shuhaila Necrotizing autoimmune myopathy: a case series |
| title | Necrotizing autoimmune myopathy: a case series |
| title_full | Necrotizing autoimmune myopathy: a case series |
| title_fullStr | Necrotizing autoimmune myopathy: a case series |
| title_full_unstemmed | Necrotizing autoimmune myopathy: a case series |
| title_short | Necrotizing autoimmune myopathy: a case series |
| title_sort | necrotizing autoimmune myopathy a case series |
| url | http://psasir.upm.edu.my/id/eprint/90297/1/13upm.pdf |
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