Adverse pregnancy outcomes are associated with lower cut-offs for maternal hyperglycemia in Malaysian women: a retrospective cohort study
Introduction: This cohort aimed to determine glycemia distribution of pregnant women and maternal glycemia categories and its correlation with adverse pregnancy outcomes among Malaysian women. Methods: A retrospective cohort study of normal glycemia pregnant women. Binary logistic regression was use...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/90362/1/2021062815345309_MJMHS_0601.pdf |
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| author | Yong, Heng Yaw Mohd Shariff, Zalilah Rejali, Zulida Mohd Yusof, Barakatun Nisak Bindels, Jacques Tee, Yvonne Yee Siang van der Beek, Eline M. |
| author_facet | Yong, Heng Yaw Mohd Shariff, Zalilah Rejali, Zulida Mohd Yusof, Barakatun Nisak Bindels, Jacques Tee, Yvonne Yee Siang van der Beek, Eline M. |
| author_sort | Yong, Heng Yaw |
| collection | UPM |
| description | Introduction: This cohort aimed to determine glycemia distribution of pregnant women and maternal glycemia categories and its correlation with adverse pregnancy outcomes among Malaysian women. Methods: A retrospective cohort study of normal glycemia pregnant women. Binary logistic regression was used to examine the associations between maternal glycemia categories and adverse outcomes. Results: Women with elevated fasting plasma glucose (FPG) were at lower risk of having SGA infants (aORFPG 4= 0.64, 95% CI= 0.47 – 0.85; aORFPG 6= 0.68, 95% CI= 0.43– 0.98; aORFPG 7= 0.64, 95% CI= 0.42–0.96) than those women in category 1. Women in the higher 2-hour plasma glucose (2hPG) category had a nearly two-fold risk of having LBW and LGA infants. Hyperglycemia less severe than gestational diabetes mellitus (GDM) was associated with LGA (aOR= 1.22, 95% CI= 1.07 – 1.88) and caesarean delivery (aOR= 1.80, 95% CI= 1.20 – 2.69), in the meanwhile GDM was associated with caesarean delivery (aOR= 1.33, 95% CI= 1.02 –1.79). Conclusion: Cut-off points for FPG and 2hPG that relate to adverse pregnancy outcomes started at 4.9 – 5.0 mmol/l and 7.5 – 7.7 mmol/l. These cut-off points were lower than the current recommended criteria of Clinical Practice Guideline (CPG) of Malaysia for GDM diagnosis. Large-scale studies are required to identify the optimal GDM cut-off. |
| first_indexed | 2024-03-06T10:50:03Z |
| format | Article |
| id | upm.eprints-90362 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:50:03Z |
| publishDate | 2021 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-903622021-09-10T01:13:33Z http://psasir.upm.edu.my/id/eprint/90362/ Adverse pregnancy outcomes are associated with lower cut-offs for maternal hyperglycemia in Malaysian women: a retrospective cohort study Yong, Heng Yaw Mohd Shariff, Zalilah Rejali, Zulida Mohd Yusof, Barakatun Nisak Bindels, Jacques Tee, Yvonne Yee Siang van der Beek, Eline M. Introduction: This cohort aimed to determine glycemia distribution of pregnant women and maternal glycemia categories and its correlation with adverse pregnancy outcomes among Malaysian women. Methods: A retrospective cohort study of normal glycemia pregnant women. Binary logistic regression was used to examine the associations between maternal glycemia categories and adverse outcomes. Results: Women with elevated fasting plasma glucose (FPG) were at lower risk of having SGA infants (aORFPG 4= 0.64, 95% CI= 0.47 – 0.85; aORFPG 6= 0.68, 95% CI= 0.43– 0.98; aORFPG 7= 0.64, 95% CI= 0.42–0.96) than those women in category 1. Women in the higher 2-hour plasma glucose (2hPG) category had a nearly two-fold risk of having LBW and LGA infants. Hyperglycemia less severe than gestational diabetes mellitus (GDM) was associated with LGA (aOR= 1.22, 95% CI= 1.07 – 1.88) and caesarean delivery (aOR= 1.80, 95% CI= 1.20 – 2.69), in the meanwhile GDM was associated with caesarean delivery (aOR= 1.33, 95% CI= 1.02 –1.79). Conclusion: Cut-off points for FPG and 2hPG that relate to adverse pregnancy outcomes started at 4.9 – 5.0 mmol/l and 7.5 – 7.7 mmol/l. These cut-off points were lower than the current recommended criteria of Clinical Practice Guideline (CPG) of Malaysia for GDM diagnosis. Large-scale studies are required to identify the optimal GDM cut-off. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2021-07 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90362/1/2021062815345309_MJMHS_0601.pdf Yong, Heng Yaw and Mohd Shariff, Zalilah and Rejali, Zulida and Mohd Yusof, Barakatun Nisak and Bindels, Jacques and Tee, Yvonne Yee Siang and van der Beek, Eline M. (2021) Adverse pregnancy outcomes are associated with lower cut-offs for maternal hyperglycemia in Malaysian women: a retrospective cohort study. Malaysian Journal of Medicine and Health Sciences, 17 (3). pp. 55-62. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2021062815345309_MJMHS_0601.pdf |
| spellingShingle | Yong, Heng Yaw Mohd Shariff, Zalilah Rejali, Zulida Mohd Yusof, Barakatun Nisak Bindels, Jacques Tee, Yvonne Yee Siang van der Beek, Eline M. Adverse pregnancy outcomes are associated with lower cut-offs for maternal hyperglycemia in Malaysian women: a retrospective cohort study |
| title | Adverse pregnancy outcomes are associated with lower cut-offs for maternal hyperglycemia in Malaysian women: a retrospective cohort study |
| title_full | Adverse pregnancy outcomes are associated with lower cut-offs for maternal hyperglycemia in Malaysian women: a retrospective cohort study |
| title_fullStr | Adverse pregnancy outcomes are associated with lower cut-offs for maternal hyperglycemia in Malaysian women: a retrospective cohort study |
| title_full_unstemmed | Adverse pregnancy outcomes are associated with lower cut-offs for maternal hyperglycemia in Malaysian women: a retrospective cohort study |
| title_short | Adverse pregnancy outcomes are associated with lower cut-offs for maternal hyperglycemia in Malaysian women: a retrospective cohort study |
| title_sort | adverse pregnancy outcomes are associated with lower cut offs for maternal hyperglycemia in malaysian women a retrospective cohort study |
| url | http://psasir.upm.edu.my/id/eprint/90362/1/2021062815345309_MJMHS_0601.pdf |
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