Kappaphycus alvarezii supplementation attenuates blood pressure, blood cholesterol, ACE and antioxidant activities in hypertensive and hypercholesteroleamic rats
Introduction: Kappaphycus alvarezii (K. alvarezii) or locally known as red seaweed, was claimed to improve health and well-being. The goal of this study is to investigate how K. alvarezii affects blood pressure (BP), total cholesterol (TC), ACE, and antioxidant activities in rats with hyperten-sion...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/93956/1/2021122719254712_2021_0829.pdf |
| _version_ | 1825937384092467200 |
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| author | Mahadi, Mahani Azizul, Mohamad Syahmi Eshak, Zolkapli Ibrahim, Aida Hamimi Md Akim, Abdah Kamal, Nurkhalida |
| author_facet | Mahadi, Mahani Azizul, Mohamad Syahmi Eshak, Zolkapli Ibrahim, Aida Hamimi Md Akim, Abdah Kamal, Nurkhalida |
| author_sort | Mahadi, Mahani |
| collection | UPM |
| description | Introduction: Kappaphycus alvarezii (K. alvarezii) or locally known as red seaweed, was claimed to improve health and well-being. The goal of this study is to investigate how K. alvarezii affects blood pressure (BP), total cholesterol (TC), ACE, and antioxidant activities in rats with hyperten-sion and hypercholesterolemia (HTN-HC). Methods: Induction of HTN-HC was achieved by feeding rats a high sodium fat diet containing 1% cholesterol+7% sodium chloride (NaCl) for 6 weeks except for Normal group. HTN-HC rats were then supplemented with K. alvarezii (5 % (w/w) or 10% (w/w) per food intake) or treated with Captopril 30mg/kg/day + Simvastatin 2 mg/kg/day, or on similar diet for another 4 weeks. Before and after induction, as well as after treatment, BP and TC were measured. The rats’ TC, ACE, and antioxidant activities were analysed using blood and liver samples. Results: The results demonstrate that BP and TC were significantly higher in all groups except the Normal Control after the induction period (p<0.05). Drug-treated rats (statin and captopril) and K. al-varezii significantly lowered BP and TC levels when compared to the HTN-HC group (p<0.05). Compared to the drug-treated and K. alvarezii groups, the HTN-HC group had the highest ACE activity (p<0.05). Meanwhile, HTN-HC rats had the lowest FRAP value and the highest CAT activities, while 10% K. alvarezii had the opposite reading (p<0.05). Conclusion: In conclusion, K. alvarezii improves blood pressure and total cholesterol levels while decreasing ACE activity in HTN-HC induced rats. |
| first_indexed | 2024-03-06T10:58:41Z |
| format | Article |
| id | upm.eprints-93956 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:58:41Z |
| publishDate | 2021 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-939562023-05-17T08:38:29Z http://psasir.upm.edu.my/id/eprint/93956/ Kappaphycus alvarezii supplementation attenuates blood pressure, blood cholesterol, ACE and antioxidant activities in hypertensive and hypercholesteroleamic rats Mahadi, Mahani Azizul, Mohamad Syahmi Eshak, Zolkapli Ibrahim, Aida Hamimi Md Akim, Abdah Kamal, Nurkhalida Introduction: Kappaphycus alvarezii (K. alvarezii) or locally known as red seaweed, was claimed to improve health and well-being. The goal of this study is to investigate how K. alvarezii affects blood pressure (BP), total cholesterol (TC), ACE, and antioxidant activities in rats with hyperten-sion and hypercholesterolemia (HTN-HC). Methods: Induction of HTN-HC was achieved by feeding rats a high sodium fat diet containing 1% cholesterol+7% sodium chloride (NaCl) for 6 weeks except for Normal group. HTN-HC rats were then supplemented with K. alvarezii (5 % (w/w) or 10% (w/w) per food intake) or treated with Captopril 30mg/kg/day + Simvastatin 2 mg/kg/day, or on similar diet for another 4 weeks. Before and after induction, as well as after treatment, BP and TC were measured. The rats’ TC, ACE, and antioxidant activities were analysed using blood and liver samples. Results: The results demonstrate that BP and TC were significantly higher in all groups except the Normal Control after the induction period (p<0.05). Drug-treated rats (statin and captopril) and K. al-varezii significantly lowered BP and TC levels when compared to the HTN-HC group (p<0.05). Compared to the drug-treated and K. alvarezii groups, the HTN-HC group had the highest ACE activity (p<0.05). Meanwhile, HTN-HC rats had the lowest FRAP value and the highest CAT activities, while 10% K. alvarezii had the opposite reading (p<0.05). Conclusion: In conclusion, K. alvarezii improves blood pressure and total cholesterol levels while decreasing ACE activity in HTN-HC induced rats. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/93956/1/2021122719254712_2021_0829.pdf Mahadi, Mahani and Azizul, Mohamad Syahmi and Eshak, Zolkapli and Ibrahim, Aida Hamimi and Md Akim, Abdah and Kamal, Nurkhalida (2021) Kappaphycus alvarezii supplementation attenuates blood pressure, blood cholesterol, ACE and antioxidant activities in hypertensive and hypercholesteroleamic rats. Malaysian Journal of Medicine and Health Sciences, 17 (11). 72 - 80. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2021122719254712_2021_0829.pdf |
| spellingShingle | Mahadi, Mahani Azizul, Mohamad Syahmi Eshak, Zolkapli Ibrahim, Aida Hamimi Md Akim, Abdah Kamal, Nurkhalida Kappaphycus alvarezii supplementation attenuates blood pressure, blood cholesterol, ACE and antioxidant activities in hypertensive and hypercholesteroleamic rats |
| title | Kappaphycus alvarezii supplementation attenuates blood pressure, blood cholesterol, ACE and antioxidant activities in hypertensive and hypercholesteroleamic rats |
| title_full | Kappaphycus alvarezii supplementation attenuates blood pressure, blood cholesterol, ACE and antioxidant activities in hypertensive and hypercholesteroleamic rats |
| title_fullStr | Kappaphycus alvarezii supplementation attenuates blood pressure, blood cholesterol, ACE and antioxidant activities in hypertensive and hypercholesteroleamic rats |
| title_full_unstemmed | Kappaphycus alvarezii supplementation attenuates blood pressure, blood cholesterol, ACE and antioxidant activities in hypertensive and hypercholesteroleamic rats |
| title_short | Kappaphycus alvarezii supplementation attenuates blood pressure, blood cholesterol, ACE and antioxidant activities in hypertensive and hypercholesteroleamic rats |
| title_sort | kappaphycus alvarezii supplementation attenuates blood pressure blood cholesterol ace and antioxidant activities in hypertensive and hypercholesteroleamic rats |
| url | http://psasir.upm.edu.my/id/eprint/93956/1/2021122719254712_2021_0829.pdf |
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