Membranous glomerulonephritis: a retrospective study on prognostic outcome
Background: Membranous glomerulonephritis (MGN) is one of the most common causes of nephrotic syndrome in non-diabetic adults, accounting for up to one-third of biopsy diagnostics in some regions. A watchful waiting strategy has been adopted to accurately assess the success of MGN. In this study, we...
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Association of Specialist Medical Doctors in Academics (ASMeDA), Sokoto, Nigeria
2021
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| author | Maifata, Sadiq Mu'azu Hod, Rafidah Zakaria, Fadhlina Abd Ghani, Fauzah |
| author_facet | Maifata, Sadiq Mu'azu Hod, Rafidah Zakaria, Fadhlina Abd Ghani, Fauzah |
| author_sort | Maifata, Sadiq Mu'azu |
| collection | UPM |
| description | Background: Membranous glomerulonephritis (MGN) is one of the most common causes of nephrotic syndrome in non-diabetic adults, accounting for up to one-third of biopsy diagnostics in some regions. A watchful waiting strategy has been adopted to accurately assess the success of MGN. In this study, we predict prognostic risk factors for primary MGN patients for effective intervention. Materials and Methods: This is a retrospective study design involving 125 biopsy-proven MGN subjects on follow-up from January 2012 to October 2019 in Hospital Serdang and Hospital Kuala Lumpur, Malaysia. Result and Conclusion: After the median follow-up of 36 (15.0-57.0) in months, 26 (20.8%) consisting of 17 (13.6%) primary MGN and 9 (7.2%) secondary MGN subjects achieved complete remission while 17 (13.6%) and 10 (8.0%) of primary and secondary MGN subjects respectively achieved spontaneous remission. Subjects with nephrotic range proteinuria have 2.917 odds more at risk of primary MGN while subjects with hypertension have 2.417 odds risk of primary MGN compared to those with no hypertension at presentation. Multiple logistic regression models retained only factors directly associated with MGN with only nephrotic range proteinuria associated with primary MGN. Those with nephrotic range proteinuria were 3.04 times the odds of primary MGN when compared with those without nephrotic syndrome (95% C. I = 1.089, 8.472). The nephrotic syndrome could be used to determine the prognosis in patients with primary MGN especially those at risk of end-stage renal disease. |
| first_indexed | 2024-03-06T10:59:03Z |
| format | Article |
| id | upm.eprints-94148 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T10:59:03Z |
| publishDate | 2021 |
| publisher | Association of Specialist Medical Doctors in Academics (ASMeDA), Sokoto, Nigeria |
| record_format | dspace |
| spelling | upm.eprints-941482023-05-23T02:27:16Z http://psasir.upm.edu.my/id/eprint/94148/ Membranous glomerulonephritis: a retrospective study on prognostic outcome Maifata, Sadiq Mu'azu Hod, Rafidah Zakaria, Fadhlina Abd Ghani, Fauzah Background: Membranous glomerulonephritis (MGN) is one of the most common causes of nephrotic syndrome in non-diabetic adults, accounting for up to one-third of biopsy diagnostics in some regions. A watchful waiting strategy has been adopted to accurately assess the success of MGN. In this study, we predict prognostic risk factors for primary MGN patients for effective intervention. Materials and Methods: This is a retrospective study design involving 125 biopsy-proven MGN subjects on follow-up from January 2012 to October 2019 in Hospital Serdang and Hospital Kuala Lumpur, Malaysia. Result and Conclusion: After the median follow-up of 36 (15.0-57.0) in months, 26 (20.8%) consisting of 17 (13.6%) primary MGN and 9 (7.2%) secondary MGN subjects achieved complete remission while 17 (13.6%) and 10 (8.0%) of primary and secondary MGN subjects respectively achieved spontaneous remission. Subjects with nephrotic range proteinuria have 2.917 odds more at risk of primary MGN while subjects with hypertension have 2.417 odds risk of primary MGN compared to those with no hypertension at presentation. Multiple logistic regression models retained only factors directly associated with MGN with only nephrotic range proteinuria associated with primary MGN. Those with nephrotic range proteinuria were 3.04 times the odds of primary MGN when compared with those without nephrotic syndrome (95% C. I = 1.089, 8.472). The nephrotic syndrome could be used to determine the prognosis in patients with primary MGN especially those at risk of end-stage renal disease. Association of Specialist Medical Doctors in Academics (ASMeDA), Sokoto, Nigeria 2021-06 Article PeerReviewed Maifata, Sadiq Mu'azu and Hod, Rafidah and Zakaria, Fadhlina and Abd Ghani, Fauzah (2021) Membranous glomerulonephritis: a retrospective study on prognostic outcome. Annals of Clinical and Experimental Medicine, 2 (1). 206 - 210. ISSN 2714-4666; ESSN: 2714-4674 https://asmeda.org/acemedicine/view_publication.php?file_name=Maifat%20et%20al.pdf&volume=2&issue=1&year=2021 10.47838/acem.26011977.127122021.asmeda.1.5 |
| spellingShingle | Maifata, Sadiq Mu'azu Hod, Rafidah Zakaria, Fadhlina Abd Ghani, Fauzah Membranous glomerulonephritis: a retrospective study on prognostic outcome |
| title | Membranous glomerulonephritis: a retrospective study on prognostic outcome |
| title_full | Membranous glomerulonephritis: a retrospective study on prognostic outcome |
| title_fullStr | Membranous glomerulonephritis: a retrospective study on prognostic outcome |
| title_full_unstemmed | Membranous glomerulonephritis: a retrospective study on prognostic outcome |
| title_short | Membranous glomerulonephritis: a retrospective study on prognostic outcome |
| title_sort | membranous glomerulonephritis a retrospective study on prognostic outcome |
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