mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells
Background: Breast cancer is one of the most common types of cancer and heterogeneous disease. Somatostatin receptors (SSTRs) are expressed in normal and tumour tissues including breast cancer cells. Objective: The aim of this study to evaluate the expression of SSTRs subtypes 1 – 5 in MCF7 and MD...
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| Format: | Article |
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Radiance Bahu - Uddeshiya Sanstha
2021
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| _version_ | 1825937434358054912 |
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| author | Mahmoud, Alkhansa Mancuso, María Teresa Tanno, Barbara Abu Bakar, Md Zuki Hamzah, Hazilawati Mohd Noor, Mohd Hezmee |
| author_facet | Mahmoud, Alkhansa Mancuso, María Teresa Tanno, Barbara Abu Bakar, Md Zuki Hamzah, Hazilawati Mohd Noor, Mohd Hezmee |
| author_sort | Mahmoud, Alkhansa |
| collection | UPM |
| description | Background: Breast cancer is one of the most common types of cancer and heterogeneous disease. Somatostatin receptors
(SSTRs) are expressed in normal and tumour tissues including breast cancer cells.
Objective: The aim of this study to evaluate the expression of SSTRs subtypes 1 – 5 in MCF7 and MDA-MB231 human breast
cancer cell lines and compare the levels between two cells.
Methods: The detection of mRNA expression levels of SSTRs in MCF7 and MDA-MB231 was performed using quantitativepolymerase chain reaction (qPCR).
Results: SSTR1, 2, 3 and 4 mRNA levels were significantly higher in MDA-MB-231 about MCF-7. The expression of SSTR 4
mRNA was highest in MDA-MB231 and MCF-7 cell lines, however, SSTR3 mRNA was least expressed in both cell lines.
Conclusion: SSTRs subtypes (1 – 5) were expressed in both MDA-MB231 and MCF7 cells. However, the levels of expression
differ between both cell lines. |
| first_indexed | 2024-03-06T10:59:26Z |
| format | Article |
| id | upm.eprints-94283 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T10:59:26Z |
| publishDate | 2021 |
| publisher | Radiance Bahu - Uddeshiya Sanstha |
| record_format | dspace |
| spelling | upm.eprints-942832023-05-08T04:41:09Z http://psasir.upm.edu.my/id/eprint/94283/ mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells Mahmoud, Alkhansa Mancuso, María Teresa Tanno, Barbara Abu Bakar, Md Zuki Hamzah, Hazilawati Mohd Noor, Mohd Hezmee Background: Breast cancer is one of the most common types of cancer and heterogeneous disease. Somatostatin receptors (SSTRs) are expressed in normal and tumour tissues including breast cancer cells. Objective: The aim of this study to evaluate the expression of SSTRs subtypes 1 – 5 in MCF7 and MDA-MB231 human breast cancer cell lines and compare the levels between two cells. Methods: The detection of mRNA expression levels of SSTRs in MCF7 and MDA-MB231 was performed using quantitativepolymerase chain reaction (qPCR). Results: SSTR1, 2, 3 and 4 mRNA levels were significantly higher in MDA-MB-231 about MCF-7. The expression of SSTR 4 mRNA was highest in MDA-MB231 and MCF-7 cell lines, however, SSTR3 mRNA was least expressed in both cell lines. Conclusion: SSTRs subtypes (1 – 5) were expressed in both MDA-MB231 and MCF7 cells. However, the levels of expression differ between both cell lines. Radiance Bahu - Uddeshiya Sanstha 2021-03-20 Article PeerReviewed Mahmoud, Alkhansa and Mancuso, María Teresa and Tanno, Barbara and Abu Bakar, Md Zuki and Hamzah, Hazilawati and Mohd Noor, Mohd Hezmee (2021) mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells. International Journal of Current Research and Review, 13 (6). pp. 9-13. ISSN 2231-2196; ESSN: 0975-5241 https://ijcrr.com/abstract.php?article_id=3497 10.31782/IJCRR.2021.13601 |
| spellingShingle | Mahmoud, Alkhansa Mancuso, María Teresa Tanno, Barbara Abu Bakar, Md Zuki Hamzah, Hazilawati Mohd Noor, Mohd Hezmee mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells |
| title | mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells |
| title_full | mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells |
| title_fullStr | mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells |
| title_full_unstemmed | mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells |
| title_short | mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells |
| title_sort | mrna expression of somatostatin receptors 1 5 in mcf7 and mda mb231 breast cancer cells |
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