Natural product-based nanomedicine: recent advances and issues for the treatment of Alzheimer's disease
Alzheimer's disease (AD) affects the elderly and is characterized by progressive neurodegeneration caused by different pathologies. The most significant challenges in treating AD include the inability of medications to reach the brain because of its poor solubility, low bioavailability, and the...
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| Format: | Article |
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Bentham Science Publishers
2022
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| _version_ | 1825937444513513472 |
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| author | Choy, Ker Woon Wong, Kah Hui Abas, Razif Haron, Muhammad Huzaimi Das, Srijit Teoh Seong, Lin |
| author_facet | Choy, Ker Woon Wong, Kah Hui Abas, Razif Haron, Muhammad Huzaimi Das, Srijit Teoh Seong, Lin |
| author_sort | Choy, Ker Woon |
| collection | UPM |
| description | Alzheimer's disease (AD) affects the elderly and is characterized by progressive neurodegeneration caused by different pathologies. The most significant challenges in treating AD include the inability of medications to reach the brain because of its poor solubility, low bioavailability, and the presence of the blood-brain barrier (BBB). Additionally, current evidence suggests the disruption of BBB plays an important role in the pathogenesis of AD. One of the critical challenges in treating AD is the ineffective treatments and their severe adverse effects. Nanotechnology offers an alternative approach to facilitate the treatment of AD by overcoming the challenges in drug transport across the BBB. Various nanoparticles (NP) loaded with natural products were reported to aid in drug delivery for the treatment of AD. The nano-sized entities of NP are great platforms for incorporating active materials from natural products into formulations that can be delivered effectively to the intended action site without compromising the material's bioactivity. The review highlights the applications of medicinal plants, their derived components, and various nanomedicinebased approaches for the treatment of AD. The combination of medicinal plants and nanotechnology may lead to new theragnostic solutions for the treatment of AD in the future. |
| first_indexed | 2024-03-06T10:59:35Z |
| format | Article |
| id | upm.eprints-94337 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T10:59:35Z |
| publishDate | 2022 |
| publisher | Bentham Science Publishers |
| record_format | dspace |
| spelling | upm.eprints-943372023-04-05T02:41:35Z http://psasir.upm.edu.my/id/eprint/94337/ Natural product-based nanomedicine: recent advances and issues for the treatment of Alzheimer's disease Choy, Ker Woon Wong, Kah Hui Abas, Razif Haron, Muhammad Huzaimi Das, Srijit Teoh Seong, Lin Alzheimer's disease (AD) affects the elderly and is characterized by progressive neurodegeneration caused by different pathologies. The most significant challenges in treating AD include the inability of medications to reach the brain because of its poor solubility, low bioavailability, and the presence of the blood-brain barrier (BBB). Additionally, current evidence suggests the disruption of BBB plays an important role in the pathogenesis of AD. One of the critical challenges in treating AD is the ineffective treatments and their severe adverse effects. Nanotechnology offers an alternative approach to facilitate the treatment of AD by overcoming the challenges in drug transport across the BBB. Various nanoparticles (NP) loaded with natural products were reported to aid in drug delivery for the treatment of AD. The nano-sized entities of NP are great platforms for incorporating active materials from natural products into formulations that can be delivered effectively to the intended action site without compromising the material's bioactivity. The review highlights the applications of medicinal plants, their derived components, and various nanomedicinebased approaches for the treatment of AD. The combination of medicinal plants and nanotechnology may lead to new theragnostic solutions for the treatment of AD in the future. Bentham Science Publishers 2022-03-25 Article PeerReviewed Choy, Ker Woon and Wong, Kah Hui and Abas, Razif and Haron, Muhammad Huzaimi and Das, Srijit and Teoh Seong, Lin (2022) Natural product-based nanomedicine: recent advances and issues for the treatment of Alzheimer's disease. Current Neuropharmacology, 20 (8). pp. 1498-1518. ISSN 1570-159X; ESSN: 1875-6190 https://www.eurekaselect.com/article/119503 10.2174/1570159X20666211217163540 |
| spellingShingle | Choy, Ker Woon Wong, Kah Hui Abas, Razif Haron, Muhammad Huzaimi Das, Srijit Teoh Seong, Lin Natural product-based nanomedicine: recent advances and issues for the treatment of Alzheimer's disease |
| title | Natural product-based nanomedicine: recent advances and issues for the treatment of Alzheimer's disease |
| title_full | Natural product-based nanomedicine: recent advances and issues for the treatment of Alzheimer's disease |
| title_fullStr | Natural product-based nanomedicine: recent advances and issues for the treatment of Alzheimer's disease |
| title_full_unstemmed | Natural product-based nanomedicine: recent advances and issues for the treatment of Alzheimer's disease |
| title_short | Natural product-based nanomedicine: recent advances and issues for the treatment of Alzheimer's disease |
| title_sort | natural product based nanomedicine recent advances and issues for the treatment of alzheimer s disease |
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