Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies
Nigella is a small genus of the family Ranunculaceae, which includes some popular species due to their culinary and medicinal properties, especially in Eastern Europe, Middle East, Western, and Central Asia. Therefore, this review covers the traditional uses and phytochemical composition of Nigella...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Frontiers Media
2021
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| _version_ | 1796982968930009088 |
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| author | Salehi, Bahare Quispe, Cristina Imran, Muhammad Ul-Haq, Iahtisham Živković, Jelena Abu-Reidah, Ibrahim M. Sen, Surjit Taheri, Yasaman Acharya, Krishnendu Azadi, Hamed del Mar Contreras, María Segura-Carretero, Antonio Mnayer, Dima Sethi, Gautam Martorell, Miquel Abdull Razis, Ahmad Faizal Sunusi, Usman Muhammad Kamal, Ramla Suleria, Hafiz Ansar Rasul Suleria Sharifi-Rad, Javad |
| author_facet | Salehi, Bahare Quispe, Cristina Imran, Muhammad Ul-Haq, Iahtisham Živković, Jelena Abu-Reidah, Ibrahim M. Sen, Surjit Taheri, Yasaman Acharya, Krishnendu Azadi, Hamed del Mar Contreras, María Segura-Carretero, Antonio Mnayer, Dima Sethi, Gautam Martorell, Miquel Abdull Razis, Ahmad Faizal Sunusi, Usman Muhammad Kamal, Ramla Suleria, Hafiz Ansar Rasul Suleria Sharifi-Rad, Javad |
| author_sort | Salehi, Bahare |
| collection | UPM |
| description | Nigella is a small genus of the family Ranunculaceae, which includes some popular species due to their culinary and medicinal properties, especially in Eastern Europe, Middle East, Western, and Central Asia. Therefore, this review covers the traditional uses and phytochemical composition of Nigella and, in particular, Nigella sativa. The pharmacological studies reported in vitro, in vivo, and in humans have also been reviewed. One of the main strength of the use of Nigella is that the seeds are rich in the omega-6 fatty acid linoleic acid and provide an extra-source of dietary phytochemicals, including the bioactive thymoquinone, and characteristics saponins, alkaloids, and flavonoids. Among Nigella species, N. sativa L. is the most studied plant from the genus. Due to the phytochemical composition and pharmacological properties, the seed and seed oil from this plant can be considered as good candidates to formulate functional ingredients on the basis of folklore and scientific knowledge. Nonetheless, the main limations are that more studies, especially, clinical trials are required to standardize the results, e.g. to establish active molecules, dosage, chemical profile, long-term effects and impact of cooking/incorporation into foods. |
| first_indexed | 2024-03-06T10:59:39Z |
| format | Article |
| id | upm.eprints-94357 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T10:59:39Z |
| publishDate | 2021 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | upm.eprints-943572023-05-03T08:24:33Z http://psasir.upm.edu.my/id/eprint/94357/ Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies Salehi, Bahare Quispe, Cristina Imran, Muhammad Ul-Haq, Iahtisham Živković, Jelena Abu-Reidah, Ibrahim M. Sen, Surjit Taheri, Yasaman Acharya, Krishnendu Azadi, Hamed del Mar Contreras, María Segura-Carretero, Antonio Mnayer, Dima Sethi, Gautam Martorell, Miquel Abdull Razis, Ahmad Faizal Sunusi, Usman Muhammad Kamal, Ramla Suleria, Hafiz Ansar Rasul Suleria Sharifi-Rad, Javad Nigella is a small genus of the family Ranunculaceae, which includes some popular species due to their culinary and medicinal properties, especially in Eastern Europe, Middle East, Western, and Central Asia. Therefore, this review covers the traditional uses and phytochemical composition of Nigella and, in particular, Nigella sativa. The pharmacological studies reported in vitro, in vivo, and in humans have also been reviewed. One of the main strength of the use of Nigella is that the seeds are rich in the omega-6 fatty acid linoleic acid and provide an extra-source of dietary phytochemicals, including the bioactive thymoquinone, and characteristics saponins, alkaloids, and flavonoids. Among Nigella species, N. sativa L. is the most studied plant from the genus. Due to the phytochemical composition and pharmacological properties, the seed and seed oil from this plant can be considered as good candidates to formulate functional ingredients on the basis of folklore and scientific knowledge. Nonetheless, the main limations are that more studies, especially, clinical trials are required to standardize the results, e.g. to establish active molecules, dosage, chemical profile, long-term effects and impact of cooking/incorporation into foods. Frontiers Media 2021-04 Article PeerReviewed Salehi, Bahare and Quispe, Cristina and Imran, Muhammad and Ul-Haq, Iahtisham and Živković, Jelena and Abu-Reidah, Ibrahim M. and Sen, Surjit and Taheri, Yasaman and Acharya, Krishnendu and Azadi, Hamed and del Mar Contreras, María and Segura-Carretero, Antonio and Mnayer, Dima and Sethi, Gautam and Martorell, Miquel and Abdull Razis, Ahmad Faizal and Sunusi, Usman and Muhammad Kamal, Ramla and Suleria, Hafiz Ansar Rasul Suleria and Sharifi-Rad, Javad (2021) Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies. Frontiers in Pharmacology, 12. art. no. 625386. pp. 1-26. ISSN 1663-9812 https://www.frontiersin.org/articles/10.3389/fphar.2021.625386/full 10.3389/fphar.2021.625386 |
| spellingShingle | Salehi, Bahare Quispe, Cristina Imran, Muhammad Ul-Haq, Iahtisham Živković, Jelena Abu-Reidah, Ibrahim M. Sen, Surjit Taheri, Yasaman Acharya, Krishnendu Azadi, Hamed del Mar Contreras, María Segura-Carretero, Antonio Mnayer, Dima Sethi, Gautam Martorell, Miquel Abdull Razis, Ahmad Faizal Sunusi, Usman Muhammad Kamal, Ramla Suleria, Hafiz Ansar Rasul Suleria Sharifi-Rad, Javad Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies |
| title | Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies |
| title_full | Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies |
| title_fullStr | Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies |
| title_full_unstemmed | Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies |
| title_short | Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies |
| title_sort | nigella plants traditional uses bioactive phytoconstituents preclinical and clinical studies |
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