Pharmacoinformatics and UPLC-QTOF/ESI-MS-based phytochemical screening of combretum indicum against oxidative stress and alloxan-induced diabetes in Long-Evans Rats

Pharmacoinformatics and UPLC-QTOF/ESI-MS-based phytochemical screening of combretum indicum against oxidative stress and alloxan-induced diabetes in Long-Evans Rats

This research investigated a UPLC-QTOF/ESI-MS-based phytochemical profiling of Combretum indicum leaf extract (CILEx), and explored its in vitro antioxidant and in vivo antidiabetic effects in a Long-Evans rat model. After a one-week intervention, the animals' blood glucose, lipid profile, and...

Full description

Bibliographic Details
Main Authors:	Forid, Md Shaekh, Rahman, Md Atiar, Mohd Aluwi, Mohd Fadhlizil Fasihi, Uddin, Md Nazim, Roy, Tapashi Ghosh, Mohanta, Milon Chandra, Huq, Akm Moyeenul, Zakaria, Zainul Amiruddin
Format:	Article
Published:	MDPI AG 2021

Similar Items

Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of <i>Combretum indicum</i> against Oxidative Stress and Alloxan-Induced Diabetes in Long–Evans Rats
by: Md. Shaekh Forid, et al.
Published: (2021-07-01)

Pharmacoinformatics and uplc-qtof/esi-ms-based phytochemical screening of combretum indicum against oxidative stress and alloxan-induced diabetes in long–evans rats
by: Forid, M. S., et al.
Published: (2021)

Qualitative dataset on UPLC-QTOF/MS tentative identification of phytochemicals from bioactive extract of Ipomoea mauritiana Jacq.
by: Alam, Istiak, et al.
Published: (2021)

Qualitative dataset on UPLC-QTOF/MS tentative identification of phytochemicals from bioactive extract of Ipomoea mauritiana Jacq.
by: Istiak Alam, et al.
Published: (2021-04-01)

Qualitative dataset on UPLC-QTOF/MS tentative identification of phytochemicals from bioactive extract of Ipomoea mauritiana Jacq
by: Alam, Istiak, et al.
Published: (2021)

Antioxidant and antibacterial activity of Ipomoea mauritiana Jacq.: a traditionally used medicinal plant in Bangladesh
by: Istiak Alam, et al.
Published: (2020-05-01)

Antidiabetic effect of actinodaphne angustifolia and profiling of bioactive metabolites using UPLC-QToF/ESI-MS method
by: F, Md. Shaekh, et al.
Published: (2023)

Role of turmeric and cinnamon spices in digestive, metabolic, and immune systems
by: Mohd Fadhlizil Fasihi, Mohd Aluwi, et al.
Published: (2021)

Antioxidant and antibacterial activity of Ipomoea mauritiana Jacq.: a traditionally used medicinal plant in Bangladesh
by: Alam, Istiak, et al.
Published: (2020)

Antidiabetic Effect of Actinodaphne angustifolia and Profiling of Bioactive Metabolites using UPLC-QToF/ESI-MS Method
by: F., Md. Shaekh, et al.
Published: (2023)

In silico evaluation of usnic acid derivatives to discover potential antibacterial drugs against DNA gyrase B and DNA topoisomerase IV
by: Miah, Roney, et al.
Published: (2023)

Molecular docking and drug-likeness study of nirmatrelvir as promising drug candidates of dengue virus NS2B-NS3 protease
by: Huq, AKM Moyeenul, et al.
Published: (2023)

Identification of pyrazole derivatives of Usnic Acid as Novel Inhibitor of SARS‑CoV‑2 main protease through virtual screening approaches
by: Roney, Miah, et al.
Published: (2023)

Identification of pyrazole derivatives of usnic acid as novel inhibitor of SARS-CoV-2 main protease through virtual screening approaches
by: Roney, Miah, et al.
Published: (2023)

In-silico Studies of Usnic Acid against DENV-3 Methyltransferase
by: Roney, Miah, et al.
Published: (2023)

Wound Healing Activity of Pyrazole-thiazole Derivatives of Curcumin Through the Docking, Pharmacokinetics, MD Simulation and MM/GBSA Approaches
by: Forid, Md Shaekh, et al.
Published: (2024)

Molecular docking and drug-likeness study of nirmatrelvir as promising drug candidates of dengue virus NS2B-NS3 protease
by: Huq, A.K.M. Moyeenul, et al.
Published: (2023)

Identification of β-cycloidal-derived mono-carbonyl curcumin analogs as potential interleukin-6 inhibitor to treat wound healing through QSAR, molecular docking, MD simulation, MM-GBSA calculation
by: Forid, Md Shaekh, et al.
Published: (2024)

Virtual screening-based identification of Potent DENV-3 RdRp protease inhibitors via in-house usnic acid derivative database
by: Roney, Miah, et al.
Published: (2021)

Combat against antibiotic resistance is a challenge in Bangladesh
by: Roney, Miah, et al.
Published: (2024)

Concerns regarding SARS-CoV-2 JN.1 mutations should be raised
by: Roney, Miah, et al.
Published: (2024)

Record dengue deaths in Bangladesh as disease patterns change
by: Roney, Miah, et al.
Published: (2024)

Oestrogenic activity of mimosine on MCF-7 breast cancer cell line through the ERα-mediated pathway
by: Huq, Akm Moyeenul, et al.
Published: (2019)

In-silico design of curcumin analogs as potential inhibitors of dengue virus NS2B/NS3 protease
by: Roney, Miah, et al.
Published: (2023)

Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
by: Roney, Miah, et al.
Published: (2024)

Molecular docking and in silico evaluation of phytochemicals of bioactive methanolic extract of Ipomoea mauritiana Jacq. as anti-bacterial agents
by: Roney, Miah, et al.
Published: (2022)

Polypharmacological assessment of amoxicillin and its analogues against the bacterial DNA gyrase B using molecular docking, DFT and molecular dynamics simulation
by: Miah, Roney, et al.
Published: (2023)

Polypharmacological assessment of Amoxicillin and its analogues against the bacterial DNA gyrase B using molecular docking, DFT and molecular dynamics simulation
by: Miah Roney, et al.
Published: (2023-12-01)

In silico analysis for discovery of dengue virus inhibitor from natural compounds
by: Roney, Miah, et al.
Published: (2022)

Comprehending the pharmacological mechanism of marine phenolic acids in bladder cancer therapy against matrix metalloproteinase 9 protein by integrated network pharmacology and in-silico approaches
by: Roney, Miah, et al.
Published: (2024)

PHARMACOINFORMATICS IN CHOLELITHIASIS PATIENTS
by: О. V. Kyrpach, et al.
Published: (2016-06-01)

Anti-diabetic activity of phloretin against maltase-glucoamylase using docking, pharmacokinetics and pharmacophore studies
by: Roney, Miah, et al.
Published: (2023)

The importance of in-silico studies in drug discovery
by: Roney, Miah, et al.
Published: (2024)

Computational studies demonstrating dithymoquinone of Nigella sativa as a potential anti-dengue agent: Short review
by: Roney, Miah, et al.
Published: (2024)

Oropouche fever outbreak is emerging concern in American countries
by: Roney, Miah, et al.
Published: (2024)

Evolution of SARS-CoV-2 from BA.2.86 to JN.1 variations and detection in Bangladesh
by: Roney, Miah, et al.
Published: (2024)

Cancer drug resistance is a serious threat in Bangladesh
by: Roney, Miah, et al.
Published: (2024)

Exploring the potential of biologically active phenolic acids from marine natural products as anticancer agents targeting the epidermal growth factor receptor
by: Roney, Miah, et al.
Published: (2023)

Modulation of antioxidant activities, markers of hepatic and renal dysfunctions in alloxan-induced diabetic rats by Combretum dolichopetalum
by: Chinedum U. EMELIKE, et al.
Published: (2023-09-01)

Gas chromatography mass spectrometry couple with quadrupole time-of-ﬂight (GC-QTOF MS) as a powerful tool for proﬁling of oxygenated sesquiterpenes in agarwood oil
by: Erny Haslina, Abd Latib, et al.
Published: (2023)