Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of Î-Glucuronidase and in silico study

Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of Î-Glucuronidase and in silico study

New benzimidazole analogues (1–18) were synthesized and characterized through different spectroscopic techniques such as 1H NMR, 13C NMR and HREI-MS. All analogues were screened for β-glucuronidase inhibitory potential. All analogues showed varied degree of inhibitory potentials with IC50 values ran...

書誌詳細
主要な著者:	Muhammad Taha, Ahmad Khan, Aftab, Rahim, Fazal, Imran, Syahrul, Mohammed Salahuddin, Uddin, Nizam, Mohammed Khan, Khalid, Ali Shah, Syed Adnan, Zafar, Ameeduzzafar, Zakaria, Zainul Amiruddin
フォーマット:	論文
出版事項:	Elsevier B.V. 2021

類似資料

Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of b-Glucuronidase and in silico study
著者:: Muhammad Taha, 等
出版事項: (2022)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
著者:: Taha, Muhammad, 等
出版事項: (2019)

In silico designing of thermostabe β-Glucuronidase (GUS)
著者:: Noorbatcha, Ibrahim Ali, 等
出版事項: (2010)

Molecular dynamics studies of human β-Glucuronidase
著者:: Noorbatcha, Ibrahim Ali, 等
出版事項: (2010)

Molecular dynamics studies of human β-glucuronidase
著者:: Noorbatcha, Ibrahim Ali, 等
出版事項: (2009)

Homology Modeling Of β-Glucuronidases From E. Coli and T. Maritima
著者:: Noorbatcha, Ibrahim Ali, 等
出版事項: (2009)

Synthesis And Biological Activity Of Benzimidazole Analogs As Sirtuin Enzyme Inhibitors
著者:: Yeong, Keng Yoon
出版事項: (2016)

QSAR study of amidino bis-benzimidazole derivatives as potent anti-malarial agents against plasmodium falciparum /
著者:: Worachartcheewan, Apilak, 等

Synthesis, Characterization And Anti-Proliferation Study Of Some Benzimidazole Derivatives
著者:: al-Douh, Mohammed Hadi Saeed
出版事項: (2010)

Characterization of the oligosaccharide component of microsomal beta-glucuronidase from rat liver.
著者:: Hoja-Łukowicz, D, 等
出版事項: (2004)

Synthesis, characterization and anti-proliferation study of some Benzimidazole derivatives
著者:: Al-Douh, Mohammed H., 等
出版事項: (2011)

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) derivatives with potent in vitro and in vivo antimalarial activity
著者:: Xue, L, 等
出版事項: (2019)

QSAR for analogs of 1,5-N,N'-disubstituted-2-(substituted benzenesulphonyl) glutamamides as antitumor agents
著者:: Panda, Parthasarathi, 等
出版事項: (2015)

Inhibition properties of arylsulfatase and β‑glucuronidase by hydrogen peroxide, hypochlorite, and peracetic acid
著者:: Zhong, Shu-Shu, 等
出版事項: (2022)

tert-Butyl 2-(1H-benzimidazol-1-yl)acetate.
著者:: N Al-Mohammed, N., 等
出版事項: (2012)

Insights from in silico exploration of major curcumin analogs targeting human dipeptidyl peptidase IV
著者:: Roney, Miah, 等
出版事項: (2024)

Microbiology of the food chain : Horizontal method for the enumeration of beta-glucuronidase-positive Escherichia coli.
著者:: British Standards Institution, owner 8096
出版事項: (2018)

2-Benzoyl-1H-benzimidazole
著者:: Ai, L., 等
出版事項: (2010)

An enzymatic approach to the desymmetrization of disubstituted pyrrolines.
著者:: Donohoe, T, 等
出版事項: (2006)

The evaluation of kLa values for recombinant Escherichia coli fermentation producing β-Glucuronidase enzyme
著者:: Mel, Maizirwan, 等
出版事項: (2010)

2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase
著者:: Sze, Wei Leong, 等
出版事項: (2016)

Microtubules as target organelles for benzimidazole anthelmintic chemotherapy.
著者:: Gull, K, 等
出版事項: (1987)

The interaction of benzimidazole carbamates with mammalian microtobule protein.
著者:: Ireland, C, 等
出版事項: (1979)

Two 1,5-disubstituted proline esters
著者:: Soave, R, 等
出版事項: (1997)

Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies
著者:: Muhammad, Akhtar, 等
出版事項: (2019)

Factors affecting delivery and transient expression of β-glucuronidase gene in Dendrobium Sonia protocorm-like-body
著者:: Abdullah, Janna Ong, 等
出版事項: (2006)

POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN
著者:: Bichard, C, 等
出版事項: (1995)

Kinetic evidence for the formation of monocationic N,N'-Disubstituted Phthalamide in tertiary Amine-Catalyzed hydrolysis of N-Substituted Phthalimides
著者:: Ariffin, Azhar, 等
出版事項: (2007)

Communicative ecology of sojourners from Pakistan and its implications for public service campaigns
著者:: Gazzaz, Osman, 等
出版事項: (2014)

Synthesis and evaluation of antimycobacterial activity of new benzimidazole aminoesters
著者:: Yoon, Y.K., 等
出版事項: (2015)

Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives
著者:: Yeong, Keng Yoon, 等
出版事項: (2013)

1H-Benzimidazol-2-ylmethyl phenyl ether
著者:: Hassan, N.D., 等
出版事項: (2009)

cis-Selective synthesis of 2,5-disubstituted pyrrolidines
著者:: Hussaini, SR, 等
出版事項: (2004)

Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library
著者:: Shaikh, F, 等
出版事項: (2019)

Comparison of Beta-Glucuronidase Expression and Anatomical Localization in Bombarded Immature Embryos of Banana Cultivar Mas via Biolistic Transformation
著者:: Chee, W.W., 等
出版事項: (2005)

Synthesis and anticancer activity of novel water soluble benzimidazole carbamates
著者:: Cheong, Jae Eun, 等
出版事項: (2018)

Pharmacokinetics And Metabolism Studies Of Antifilarial Drugs Derivatives Of Benzimidazole Carbamate
著者:: Ramanathan, Surash
出版事項: (1996)

Cytotoxicity, antimutagenicity and molecular docking of benzimidazole derivatives as anticancer agents
著者:: Azahar, Nurul Hafizan
出版事項: (2021)

The birch reduction of 3-substituted and 3,4-disubstituted pyrroles.
著者:: Harji, R, 等
出版事項: (1999)

Resistensi cacing Strongylus terhadap obat-obatan senyawa Benzimidazole
著者:: Perpustakaan UGM, i-lib
出版事項: (1988)