Synthesis of novel esters of mefenamic acid with pronounced anti-nociceptive effects and a proposed activity on GABA, opioid and glutamate receptors
Background: Mefenamic acid (MFA), a commonly prescribed non-steroidal anti-inflammatory drug (NSAID), possesses a greater risk of dose-related central nervous system (CNS) toxicity than other NSAIDs. In this study, α-tocopherol and α-tocopherol acetate were selected as prodrug moieties for MFA in an...
Main Authors: | Ayoub, Rami, Jarrar, Qais Bashir, Ali, Dalia, Moshawih, Said, Hakim, Muhammad Nazrul, Zakaria, Zainul Amiruddin |
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Format: | Article |
Published: |
Elsevier BV
2021
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