Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications
Newcastle disease, a highly contagious disease of the avian species is caused by the Newcastle disease virus (NOV). In Malaysia there have been 29 outbreaks of NOV reported this year alone. In spite of the availability of mass vaccination programmes, these sporadic outbreaks are believed to be th...
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| Format: | Thesis |
| Language: | English English |
| Published: |
2003
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| Online Access: | http://psasir.upm.edu.my/id/eprint/9534/1/FSAS_2003_2_A.pdf |
| _version_ | 1825944604650766336 |
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| author | Thurai Raja, Priadarishni Ramanujam |
| author_facet | Thurai Raja, Priadarishni Ramanujam |
| author_sort | Thurai Raja, Priadarishni Ramanujam |
| collection | UPM |
| description | Newcastle disease, a highly contagious disease of the avian species is
caused by the Newcastle disease virus (NOV). In Malaysia there have been 29
outbreaks of NOV reported this year alone. In spite of the availability of mass
vaccination programmes, these sporadic outbreaks are believed to be the result
of malpractice in backyard farming. The mechanism of NOV infection is still not
clearly understood, making it difficult to validate any effective drug candidates.
Bearing this in mind, a phage display random peptide library was used to identify
peptide ligands that interact with NOV. A phage carrying the TLTTKLY sequence
represented 97% of the total phage screened from the third round of biopanning
against NOV strain AF2240. This phage was characterized and both cyclic and
linear synthetic peptides bearing the homologous sequence were synthesized. |
| first_indexed | 2024-03-06T07:18:29Z |
| format | Thesis |
| id | upm.eprints-9534 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:18:29Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | upm.eprints-95342012-08-27T06:48:59Z http://psasir.upm.edu.my/id/eprint/9534/ Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications Thurai Raja, Priadarishni Ramanujam Newcastle disease, a highly contagious disease of the avian species is caused by the Newcastle disease virus (NOV). In Malaysia there have been 29 outbreaks of NOV reported this year alone. In spite of the availability of mass vaccination programmes, these sporadic outbreaks are believed to be the result of malpractice in backyard farming. The mechanism of NOV infection is still not clearly understood, making it difficult to validate any effective drug candidates. Bearing this in mind, a phage display random peptide library was used to identify peptide ligands that interact with NOV. A phage carrying the TLTTKLY sequence represented 97% of the total phage screened from the third round of biopanning against NOV strain AF2240. This phage was characterized and both cyclic and linear synthetic peptides bearing the homologous sequence were synthesized. 2003-01 Thesis NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/9534/1/FSAS_2003_2_A.pdf Thurai Raja, Priadarishni Ramanujam (2003) Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications. PhD thesis, Universiti Putra Malaysia. Newcastle Disease Virus - Malaysia. Peptides - Malaysia. English |
| spellingShingle | Newcastle Disease Virus - Malaysia. Peptides - Malaysia. Thurai Raja, Priadarishni Ramanujam Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
| title | Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
| title_full | Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
| title_fullStr | Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
| title_full_unstemmed | Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
| title_short | Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications |
| title_sort | peptide ligands that interact with newcastle disease virus selection characterization and applications |
| topic | Newcastle Disease Virus - Malaysia. Peptides - Malaysia. |
| url | http://psasir.upm.edu.my/id/eprint/9534/1/FSAS_2003_2_A.pdf |
| work_keys_str_mv | AT thurairajapriadarishniramanujam peptideligandsthatinteractwithnewcastlediseasevirusselectioncharacterizationandapplications |