The elastic recovery, ejection work, strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant
Croscarmellose sodium disintegrant agent, commonly used in the pharmaceutical tablet formulation was employed in the instant coffee tablet formulation. Various compositions of croscarmellose sodium were added to the instant coffee tablet formulation; 20% w/w, 40% w/w, 60% w/w and 80% w/w respectivel...
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| Format: | Article |
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Rynnye Lyan Resources
2021
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| _version_ | 1825937574590414848 |
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| author | Mohd Rosidi, N. S. Anuar, M. S. Tahir, S. M. |
| author_facet | Mohd Rosidi, N. S. Anuar, M. S. Tahir, S. M. |
| author_sort | Mohd Rosidi, N. S. |
| collection | UPM |
| description | Croscarmellose sodium disintegrant agent, commonly used in the pharmaceutical tablet formulation was employed in the instant coffee tablet formulation. Various compositions of croscarmellose sodium were added to the instant coffee tablet formulation; 20% w/w, 40% w/w, 60% w/w and 80% w/w respectively. These mixtures were then compacted through the uniaxial die compaction process forming 1 g tablets having 13 mm diameters each at various compaction pressures of 37.7 MPa, 75.4 MPa, 113.0 MPa and 150.7 MPa. The ejection work done when ejecting the tablet from the die was calculated to represent the frictional resistance to tablet motion during ejection. The tablet elastic recovery was measured as a quantitative measure of the tablet physical dimensional stability. Meanwhile, the mechanical strength, as well as the tablet dissolution, were also measured. The results showed that the croscarmellose composition and the compaction pressure affected all the studied tabletting properties. Generally, croscarmellose sodium increased the tablet elastic recovery and lowered the tablet ejection work, tensile strength and dissolution time in experimental conditions employed in this work. However, the extent of the croscarmellose sodium influence was clearly dependent upon the compaction pressures used for instant coffee tablet formation. |
| first_indexed | 2024-03-06T11:01:35Z |
| format | Article |
| id | upm.eprints-95430 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:01:35Z |
| publishDate | 2021 |
| publisher | Rynnye Lyan Resources |
| record_format | dspace |
| spelling | upm.eprints-954302023-04-06T01:26:55Z http://psasir.upm.edu.my/id/eprint/95430/ The elastic recovery, ejection work, strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant Mohd Rosidi, N. S. Anuar, M. S. Tahir, S. M. Croscarmellose sodium disintegrant agent, commonly used in the pharmaceutical tablet formulation was employed in the instant coffee tablet formulation. Various compositions of croscarmellose sodium were added to the instant coffee tablet formulation; 20% w/w, 40% w/w, 60% w/w and 80% w/w respectively. These mixtures were then compacted through the uniaxial die compaction process forming 1 g tablets having 13 mm diameters each at various compaction pressures of 37.7 MPa, 75.4 MPa, 113.0 MPa and 150.7 MPa. The ejection work done when ejecting the tablet from the die was calculated to represent the frictional resistance to tablet motion during ejection. The tablet elastic recovery was measured as a quantitative measure of the tablet physical dimensional stability. Meanwhile, the mechanical strength, as well as the tablet dissolution, were also measured. The results showed that the croscarmellose composition and the compaction pressure affected all the studied tabletting properties. Generally, croscarmellose sodium increased the tablet elastic recovery and lowered the tablet ejection work, tensile strength and dissolution time in experimental conditions employed in this work. However, the extent of the croscarmellose sodium influence was clearly dependent upon the compaction pressures used for instant coffee tablet formation. Rynnye Lyan Resources 2021 Article PeerReviewed Mohd Rosidi, N. S. and Anuar, M. S. and Tahir, S. M. (2021) The elastic recovery, ejection work, strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant. Food Research, 5 (suppl.1). 14 - 18. ISSN 2550-2166 https://www.myfoodresearch.com/vol-59474supplementary-1.html 10.26656/fr.2017.5(S1).003 |
| spellingShingle | Mohd Rosidi, N. S. Anuar, M. S. Tahir, S. M. The elastic recovery, ejection work, strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant |
| title | The elastic recovery, ejection work, strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant |
| title_full | The elastic recovery, ejection work, strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant |
| title_fullStr | The elastic recovery, ejection work, strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant |
| title_full_unstemmed | The elastic recovery, ejection work, strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant |
| title_short | The elastic recovery, ejection work, strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant |
| title_sort | elastic recovery ejection work strength and dissolution of instant coffee tablet containing croscarmellose sodium disintegrant |
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