The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
The present study focuses on the possible involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway in the antinociceptive activity of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol (BBHC) via a chemical nociceptive model in mice. The a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/95511/1/The%20involvement%20of%20L-arginine-nitric%20ox-ide-cGMP-ATP-sensitive%20K%2B%20channel%20pathway%20in%20antinocicep-tion%20of%20BBHC%2C%20a%20novel%20diarylpentanoid%20analogue%2C%20in%20mice%20model.pdf |
| _version_ | 1825937587502579712 |
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| author | Hui, Ming Ong Ahmad Azmi, Ahmad Farhan Sze, Wei Leong Abas, Faridah Perimal, Enoch Kumar Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan |
| author_facet | Hui, Ming Ong Ahmad Azmi, Ahmad Farhan Sze, Wei Leong Abas, Faridah Perimal, Enoch Kumar Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan |
| author_sort | Hui, Ming Ong |
| collection | UPM |
| description | The present study focuses on the possible involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway in the antinociceptive activity of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol (BBHC) via a chemical nociceptive model in mice. The antinociceptive action of BBHC (1 mg/kg, i.p.) was attenuated by the intraperitoneal pre-treatment of l-arginine (a nitric oxide synthase precursor) and glibenclamide (an ATP-sensitive K+ channel blocker) in acetic acid-induced abdominal constriction tests. Interestingly, BBHC’s antinociception was significantly enhanced by the i.p. pre-treatment of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), a selective inhibitor of soluble guanylyl cyclase (p < 0.05). Altogether, these findings suggest that the systemic administration of BBHC is able to establish a significant antinociceptive effect in a mice model of chemically induced pain. BBHC’s antinociception is shown to be mediated by the involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway, without any potential sedative or muscle relaxant concerns. |
| first_indexed | 2024-03-06T11:01:47Z |
| format | Article |
| id | upm.eprints-95511 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T11:01:47Z |
| publishDate | 2021 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | upm.eprints-955112023-01-04T04:27:05Z http://psasir.upm.edu.my/id/eprint/95511/ The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model Hui, Ming Ong Ahmad Azmi, Ahmad Farhan Sze, Wei Leong Abas, Faridah Perimal, Enoch Kumar Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan The present study focuses on the possible involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway in the antinociceptive activity of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol (BBHC) via a chemical nociceptive model in mice. The antinociceptive action of BBHC (1 mg/kg, i.p.) was attenuated by the intraperitoneal pre-treatment of l-arginine (a nitric oxide synthase precursor) and glibenclamide (an ATP-sensitive K+ channel blocker) in acetic acid-induced abdominal constriction tests. Interestingly, BBHC’s antinociception was significantly enhanced by the i.p. pre-treatment of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), a selective inhibitor of soluble guanylyl cyclase (p < 0.05). Altogether, these findings suggest that the systemic administration of BBHC is able to establish a significant antinociceptive effect in a mice model of chemically induced pain. BBHC’s antinociception is shown to be mediated by the involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway, without any potential sedative or muscle relaxant concerns. MDPI AG 2021-12-08 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/95511/1/The%20involvement%20of%20L-arginine-nitric%20ox-ide-cGMP-ATP-sensitive%20K%2B%20channel%20pathway%20in%20antinocicep-tion%20of%20BBHC%2C%20a%20novel%20diarylpentanoid%20analogue%2C%20in%20mice%20model.pdf Hui, Ming Ong and Ahmad Azmi, Ahmad Farhan and Sze, Wei Leong and Abas, Faridah and Perimal, Enoch Kumar and Omar Farouk, Ahmad Akira and Israf Ali, Daud Ahmad and Sulaiman, Mohd Roslan (2021) The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model. MOLECULES, 26 (24). art. no. 7431. pp. 1-11. ISSN 1431-5165; ESSN: 1420-3049 https://www.mdpi.com/1420-3049/26/24/7431 10.3390/molecules26247431 |
| spellingShingle | Hui, Ming Ong Ahmad Azmi, Ahmad Farhan Sze, Wei Leong Abas, Faridah Perimal, Enoch Kumar Omar Farouk, Ahmad Akira Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model |
| title | The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model |
| title_full | The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model |
| title_fullStr | The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model |
| title_full_unstemmed | The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model |
| title_short | The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model |
| title_sort | involvement of l arginine nitric ox ide cgmp atp sensitive k channel pathway in antinocicep tion of bbhc a novel diarylpentanoid analogue in mice model |
| url | http://psasir.upm.edu.my/id/eprint/95511/1/The%20involvement%20of%20L-arginine-nitric%20ox-ide-cGMP-ATP-sensitive%20K%2B%20channel%20pathway%20in%20antinocicep-tion%20of%20BBHC%2C%20a%20novel%20diarylpentanoid%20analogue%2C%20in%20mice%20model.pdf |
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