The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats
A trial was conducted to observe the immediate and chronic e¡ects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administra- tion of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Thos...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier Science Publishers
1999
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| Online Access: | http://psasir.upm.edu.my/id/eprint/9567/1/A_1006371821128.pdf |
| Summary: | A trial was conducted to observe the immediate and chronic e¡ects in goats of dexamethasone
administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administra-
tion of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups.
Those in group 1 were injected intramuscularly with 1 mg/kg dexamethasone on three consecutive
days, followed by intranasal exposure to formalin-killed P. haemolytica A2 one day after the last
dexamethasone treatment. The goats in group 2 were similarly injected with dexamethasone followed
by intranasal exposure to formalin-killed P. haemolytica A2 21 days after the last dexamethasone
treatment. The animals in group 3 were exposed intranasally to formalin-killed P. haemolytica A2
without prior dexamethasone treatment. The animals in group 4 were untreated controls. The
intranasal exposures to formalin-killed P. haemolytica A2 were repeated 2 weeks later. Intranasal
exposure to formalin-killed P. haemolytica 1 day after dexamethasone treatment further reduced the
number and size of BALT compared to the untreated control. Signi¢cantly (p50.01) more reduction of
BALT occurred in goats exposed to formalin-killed P. haemolytica A2 21 days after dexamethasone
treatment. On the other hand, intranasal exposure of goats without prior dexamethasone treatment
stimulated the BALT compared to the untreated controls. |
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