The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats
A trial was conducted to observe the immediate and chronic e¡ects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administra- tion of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Thos...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier Science Publishers
1999
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| Online Access: | http://psasir.upm.edu.my/id/eprint/9567/1/A_1006371821128.pdf |
| _version_ | 1825944611067002880 |
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| author | Saad, Mohd Zamri Abdul Wahid, Mohd Effendy |
| author_facet | Saad, Mohd Zamri Abdul Wahid, Mohd Effendy |
| author_sort | Saad, Mohd Zamri |
| collection | UPM |
| description | A trial was conducted to observe the immediate and chronic e¡ects in goats of dexamethasone
administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administra-
tion of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups.
Those in group 1 were injected intramuscularly with 1 mg/kg dexamethasone on three consecutive
days, followed by intranasal exposure to formalin-killed P. haemolytica A2 one day after the last
dexamethasone treatment. The goats in group 2 were similarly injected with dexamethasone followed
by intranasal exposure to formalin-killed P. haemolytica A2 21 days after the last dexamethasone
treatment. The animals in group 3 were exposed intranasally to formalin-killed P. haemolytica A2
without prior dexamethasone treatment. The animals in group 4 were untreated controls. The
intranasal exposures to formalin-killed P. haemolytica A2 were repeated 2 weeks later. Intranasal
exposure to formalin-killed P. haemolytica 1 day after dexamethasone treatment further reduced the
number and size of BALT compared to the untreated control. Signi¢cantly (p50.01) more reduction of
BALT occurred in goats exposed to formalin-killed P. haemolytica A2 21 days after dexamethasone
treatment. On the other hand, intranasal exposure of goats without prior dexamethasone treatment
stimulated the BALT compared to the untreated controls. |
| first_indexed | 2024-03-06T07:18:35Z |
| format | Article |
| id | upm.eprints-9567 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-09-25T03:31:28Z |
| publishDate | 1999 |
| publisher | Elsevier Science Publishers |
| record_format | dspace |
| spelling | upm.eprints-95672024-08-08T00:11:56Z http://psasir.upm.edu.my/id/eprint/9567/ The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats Saad, Mohd Zamri Abdul Wahid, Mohd Effendy A trial was conducted to observe the immediate and chronic e¡ects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administra- tion of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Those in group 1 were injected intramuscularly with 1 mg/kg dexamethasone on three consecutive days, followed by intranasal exposure to formalin-killed P. haemolytica A2 one day after the last dexamethasone treatment. The goats in group 2 were similarly injected with dexamethasone followed by intranasal exposure to formalin-killed P. haemolytica A2 21 days after the last dexamethasone treatment. The animals in group 3 were exposed intranasally to formalin-killed P. haemolytica A2 without prior dexamethasone treatment. The animals in group 4 were untreated controls. The intranasal exposures to formalin-killed P. haemolytica A2 were repeated 2 weeks later. Intranasal exposure to formalin-killed P. haemolytica 1 day after dexamethasone treatment further reduced the number and size of BALT compared to the untreated control. Signi¢cantly (p50.01) more reduction of BALT occurred in goats exposed to formalin-killed P. haemolytica A2 21 days after dexamethasone treatment. On the other hand, intranasal exposure of goats without prior dexamethasone treatment stimulated the BALT compared to the untreated controls. Elsevier Science Publishers 1999 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/9567/1/A_1006371821128.pdf Saad, Mohd Zamri and Abdul Wahid, Mohd Effendy (1999) The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats. Veterinary Research Communications, 23 (8). pp. 467-473. ISSN 1573-7446 https://link.springer.com/article/10.1023/A:1006371821128 10.1023/A:1006371821128 English |
| spellingShingle | Saad, Mohd Zamri Abdul Wahid, Mohd Effendy The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats |
| title | The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats |
| title_full | The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats |
| title_fullStr | The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats |
| title_full_unstemmed | The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats |
| title_short | The Effects of Dexamethasone on the Response of Bronchus-associated Lymphoid Tissue to Intranasal Administration of Formalin-killed Pasteurella haemolytica A2 in Goats |
| title_sort | effects of dexamethasone on the response of bronchus associated lymphoid tissue to intranasal administration of formalin killed pasteurella haemolytica a2 in goats |
| url | http://psasir.upm.edu.my/id/eprint/9567/1/A_1006371821128.pdf |
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