Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review
Aflatoxins (AFs) are highly toxic and cancer-causing compounds, predominantly synthesized by the Aspergillus species. AFs biosynthesis is a lengthy process that requires as minimum as 30 genes grouped inside 75 kilobytes (kB) of gene clusters, which are regulated by specific transcription factors, i...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2021
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| _version_ | 1796983137504329728 |
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| author | Khan, Rahim Mohamad Ghazali, Farinazleen Mahyudin, Nor Ainy Samsudin, Nik Iskandar Putra |
| author_facet | Khan, Rahim Mohamad Ghazali, Farinazleen Mahyudin, Nor Ainy Samsudin, Nik Iskandar Putra |
| author_sort | Khan, Rahim |
| collection | UPM |
| description | Aflatoxins (AFs) are highly toxic and cancer-causing compounds, predominantly synthesized by the Aspergillus species. AFs biosynthesis is a lengthy process that requires as minimum as 30 genes grouped inside 75 kilobytes (kB) of gene clusters, which are regulated by specific transcription factors, including aflR, aflS, and some general transcription factors. This paper summarizes the status of research on characterizing structural and regulatory genes associated with AF production and their roles in aflatoxigenic fungi, particularly Aspergillus flavus and A. parasiticus, and enhances the current understanding of AFs that adversely affect humans and animals with a great emphasis on toxicity and preventive methods. |
| first_indexed | 2024-03-06T11:02:09Z |
| format | Article |
| id | upm.eprints-95738 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:02:09Z |
| publishDate | 2021 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-957382023-04-06T07:53:42Z http://psasir.upm.edu.my/id/eprint/95738/ Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review Khan, Rahim Mohamad Ghazali, Farinazleen Mahyudin, Nor Ainy Samsudin, Nik Iskandar Putra Aflatoxins (AFs) are highly toxic and cancer-causing compounds, predominantly synthesized by the Aspergillus species. AFs biosynthesis is a lengthy process that requires as minimum as 30 genes grouped inside 75 kilobytes (kB) of gene clusters, which are regulated by specific transcription factors, including aflR, aflS, and some general transcription factors. This paper summarizes the status of research on characterizing structural and regulatory genes associated with AF production and their roles in aflatoxigenic fungi, particularly Aspergillus flavus and A. parasiticus, and enhances the current understanding of AFs that adversely affect humans and animals with a great emphasis on toxicity and preventive methods. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed Khan, Rahim and Mohamad Ghazali, Farinazleen and Mahyudin, Nor Ainy and Samsudin, Nik Iskandar Putra (2021) Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review. Journal of Fungi, 7 (8). art. no. 606. pp. 1-20. ISSN 2309-608X https://www.mdpi.com/2309-608X/7/8/606 10.3390/jof7080606 |
| spellingShingle | Khan, Rahim Mohamad Ghazali, Farinazleen Mahyudin, Nor Ainy Samsudin, Nik Iskandar Putra Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review |
| title | Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review |
| title_full | Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review |
| title_fullStr | Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review |
| title_full_unstemmed | Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review |
| title_short | Aflatoxin biosynthesis, genetic regulation, toxicity, and control strategies: a review |
| title_sort | aflatoxin biosynthesis genetic regulation toxicity and control strategies a review |
| work_keys_str_mv | AT khanrahim aflatoxinbiosynthesisgeneticregulationtoxicityandcontrolstrategiesareview AT mohamadghazalifarinazleen aflatoxinbiosynthesisgeneticregulationtoxicityandcontrolstrategiesareview AT mahyudinnorainy aflatoxinbiosynthesisgeneticregulationtoxicityandcontrolstrategiesareview AT samsudinnikiskandarputra aflatoxinbiosynthesisgeneticregulationtoxicityandcontrolstrategiesareview |