Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line
The biocompatibility of carbon nanotubes (CNT) is fairly a challenging task for their applications in nanomedicine. Therefore, the objective of this research was to formulate four types of highly biocompatible betulinic acid-loaded biopolymer nanocomposites, namely chitosan-multiwalled carbon nanotu...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2021
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| _version_ | 1825937699867983872 |
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| author | Tan, Julia Meihua Bullo, Saifullah Fakurazi, Sharida Hussein, Mohd Zobir |
| author_facet | Tan, Julia Meihua Bullo, Saifullah Fakurazi, Sharida Hussein, Mohd Zobir |
| author_sort | Tan, Julia Meihua |
| collection | UPM |
| description | The biocompatibility of carbon nanotubes (CNT) is fairly a challenging task for their applications in nanomedicine. Therefore, the objective of this research was to formulate four types of highly biocompatible betulinic acid-loaded biopolymer nanocomposites, namely chitosan-multiwalled carbon nanotubes (MWBA-CS), polyethylene glycol-multiwalled carbon nanotubes (MWBA-PG), Tween 20-multiwalled carbon nanotubes (MWBA-T2) and Tween 80-multiwalled carbon nanotubes (MWBA-T8). The physico-chemical properties of the modified nanocomposites were determined by Fourier transform infrared spectroscopy (FTIR), thermal analysis (TGA) and Raman spectroscopy, while the surface morphology of the resulting nanocomposites was studied using field emission scanning electron microscopy (FESEM). All data revealed that the external surface of MWBA nanocomposites was successfully coated with the respective polymer molecules through hydrophobic and electrostatic interactions with improved thermal profiles. The cell viability assay, which was performed on cultured normal embryonic mouse fibroblast cells, confirmed their excellent biocompatibility in phosphate-buffered saline aqueous media. Overall, our findings herein suggest that the synthesized biopolymer-coated MWBA nanocomposites are promising nanomaterials for drug delivery applications as they enhance the solubility and dispersibility of CNT with significantly reduced cytotoxic effect, especially in normal cells. |
| first_indexed | 2024-03-06T11:03:29Z |
| format | Article |
| id | upm.eprints-96359 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:03:29Z |
| publishDate | 2021 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-963592023-01-30T06:55:05Z http://psasir.upm.edu.my/id/eprint/96359/ Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line Tan, Julia Meihua Bullo, Saifullah Fakurazi, Sharida Hussein, Mohd Zobir The biocompatibility of carbon nanotubes (CNT) is fairly a challenging task for their applications in nanomedicine. Therefore, the objective of this research was to formulate four types of highly biocompatible betulinic acid-loaded biopolymer nanocomposites, namely chitosan-multiwalled carbon nanotubes (MWBA-CS), polyethylene glycol-multiwalled carbon nanotubes (MWBA-PG), Tween 20-multiwalled carbon nanotubes (MWBA-T2) and Tween 80-multiwalled carbon nanotubes (MWBA-T8). The physico-chemical properties of the modified nanocomposites were determined by Fourier transform infrared spectroscopy (FTIR), thermal analysis (TGA) and Raman spectroscopy, while the surface morphology of the resulting nanocomposites was studied using field emission scanning electron microscopy (FESEM). All data revealed that the external surface of MWBA nanocomposites was successfully coated with the respective polymer molecules through hydrophobic and electrostatic interactions with improved thermal profiles. The cell viability assay, which was performed on cultured normal embryonic mouse fibroblast cells, confirmed their excellent biocompatibility in phosphate-buffered saline aqueous media. Overall, our findings herein suggest that the synthesized biopolymer-coated MWBA nanocomposites are promising nanomaterials for drug delivery applications as they enhance the solubility and dispersibility of CNT with significantly reduced cytotoxic effect, especially in normal cells. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed Tan, Julia Meihua and Bullo, Saifullah and Fakurazi, Sharida and Hussein, Mohd Zobir (2021) Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line. Polymer, 13 (9). art. no. 1362. pp. 1-18. ISSN 2073-4360 https://www.mdpi.com/2073-4360/13/9/1362 10.3390/polym13091362 |
| spellingShingle | Tan, Julia Meihua Bullo, Saifullah Fakurazi, Sharida Hussein, Mohd Zobir Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line |
| title | Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line |
| title_full | Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line |
| title_fullStr | Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line |
| title_full_unstemmed | Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line |
| title_short | Characterization of betulinic acid-multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on NIH/3T3 cell line |
| title_sort | characterization of betulinic acid multiwalled carbon nanotubes modified with hydrophilic biopolymer for improved biocompatibility on nih 3t3 cell line |
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