Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study
The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using...
| Главные авторы: | , , , , , , , , , , , , , |
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| Формат: | Статья |
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Nature Research
2021
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| _version_ | 1825937706395369472 |
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| author | Khor, Ban Hock Sahathevan, Sharmela Sualeheen, Ayesha Md Ali, Mohammad Syafiq Narayanan, Sreelakshmi Sankara Chinna, Karuthan Abdul Gafor, Abdul Halim Goh, Bak Leong Ahmad, Ghazali Morad, Zaki Mat Daud, Zulfitri 'Azuan Khosla, Pramod Sundram, Kalyana Karupaiah, Tilakavati |
| author_facet | Khor, Ban Hock Sahathevan, Sharmela Sualeheen, Ayesha Md Ali, Mohammad Syafiq Narayanan, Sreelakshmi Sankara Chinna, Karuthan Abdul Gafor, Abdul Halim Goh, Bak Leong Ahmad, Ghazali Morad, Zaki Mat Daud, Zulfitri 'Azuan Khosla, Pramod Sundram, Kalyana Karupaiah, Tilakavati |
| author_sort | Khor, Ban Hock |
| collection | UPM |
| description | The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography in 341 patients on HD (age = 55.2 ± 14.0 years and 54.3% males). Cross-sectional associations of TG-FAs with 13 markers were examined using multivariate linear regression adjusted for potential confounders. Higher levels of TG saturated fatty acids were associated with greater body mass index (BMI, r = 0.230), waist circumference (r = 0.203), triceps skinfold (r = 0.197), fat tissue index (r = 0.150), serum insulin (r = 0.280), and homeostatic model assessment of insulin resistance (r = 0.276), but lower malnutrition inflammation score (MIS, r = − 0.160). Greater TG monounsaturated fatty acid levels were associated with lower lean tissue index (r = − 0.197) and serum albumin (r = − 0.188), but higher MIS (r = 0.176). Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r = − 0.168) and interleukin-6 concentrations (r = − 0.115). Higher levels of TG n-6 PUFAs were associated with lower BMI (r = − 0.149) but greater serum albumin (r = 0.112). In conclusion, TG monounsaturated fatty acids were associated with poor nutritional status, while TG n-3 PUFAs were associated with good nutritional status. On the other hand, TG saturated fatty acids and TG n-6 PUFAs had both favorable and unfavorable associations with nutritional parameters. |
| first_indexed | 2024-03-06T11:03:35Z |
| format | Article |
| id | upm.eprints-96394 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:03:35Z |
| publishDate | 2021 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | upm.eprints-963942023-02-10T02:03:07Z http://psasir.upm.edu.my/id/eprint/96394/ Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study Khor, Ban Hock Sahathevan, Sharmela Sualeheen, Ayesha Md Ali, Mohammad Syafiq Narayanan, Sreelakshmi Sankara Chinna, Karuthan Abdul Gafor, Abdul Halim Goh, Bak Leong Ahmad, Ghazali Morad, Zaki Mat Daud, Zulfitri 'Azuan Khosla, Pramod Sundram, Kalyana Karupaiah, Tilakavati The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography in 341 patients on HD (age = 55.2 ± 14.0 years and 54.3% males). Cross-sectional associations of TG-FAs with 13 markers were examined using multivariate linear regression adjusted for potential confounders. Higher levels of TG saturated fatty acids were associated with greater body mass index (BMI, r = 0.230), waist circumference (r = 0.203), triceps skinfold (r = 0.197), fat tissue index (r = 0.150), serum insulin (r = 0.280), and homeostatic model assessment of insulin resistance (r = 0.276), but lower malnutrition inflammation score (MIS, r = − 0.160). Greater TG monounsaturated fatty acid levels were associated with lower lean tissue index (r = − 0.197) and serum albumin (r = − 0.188), but higher MIS (r = 0.176). Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r = − 0.168) and interleukin-6 concentrations (r = − 0.115). Higher levels of TG n-6 PUFAs were associated with lower BMI (r = − 0.149) but greater serum albumin (r = 0.112). In conclusion, TG monounsaturated fatty acids were associated with poor nutritional status, while TG n-3 PUFAs were associated with good nutritional status. On the other hand, TG saturated fatty acids and TG n-6 PUFAs had both favorable and unfavorable associations with nutritional parameters. Nature Research 2021 Article PeerReviewed Khor, Ban Hock and Sahathevan, Sharmela and Sualeheen, Ayesha and Md Ali, Mohammad Syafiq and Narayanan, Sreelakshmi Sankara and Chinna, Karuthan and Abdul Gafor, Abdul Halim and Goh, Bak Leong and Ahmad, Ghazali and Morad, Zaki and Mat Daud, Zulfitri 'Azuan and Khosla, Pramod and Sundram, Kalyana and Karupaiah, Tilakavati (2021) Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study. Scientific Reports, 11. art. no. 1416. pp. 1-12. ISSN 2045-2322 https://www.nature.com/articles/s41598-020-80812-1 10.1038/s41598-020-80812-1 |
| spellingShingle | Khor, Ban Hock Sahathevan, Sharmela Sualeheen, Ayesha Md Ali, Mohammad Syafiq Narayanan, Sreelakshmi Sankara Chinna, Karuthan Abdul Gafor, Abdul Halim Goh, Bak Leong Ahmad, Ghazali Morad, Zaki Mat Daud, Zulfitri 'Azuan Khosla, Pramod Sundram, Kalyana Karupaiah, Tilakavati Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study |
| title | Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study |
| title_full | Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study |
| title_fullStr | Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study |
| title_full_unstemmed | Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study |
| title_short | Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study |
| title_sort | circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients a cross sectional study |
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