Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction?
Group B Streptococcus (GBS) is a predominant causative pathogen of neonatal meningitis that is associated with a high rate of mortality and morbidity. The establishment of antenatal screening and intrapartum chemoprophylaxis has led to a significant reduction in the incidence rate of invasive GBS di...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Malaysian Medical Association
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/96713/1/ABSTRACT.pdf |
| _version_ | 1825937753146130432 |
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| author | Zainudin, Zurina Hoo, Nicole Phing Jie Amin Nordin, Syafinaz Sither Joseph Vesudian, Narcisse Mary Nunis, Melissa Anne |
| author_facet | Zainudin, Zurina Hoo, Nicole Phing Jie Amin Nordin, Syafinaz Sither Joseph Vesudian, Narcisse Mary Nunis, Melissa Anne |
| author_sort | Zainudin, Zurina |
| collection | UPM |
| description | Group B Streptococcus (GBS) is a predominant causative pathogen of neonatal meningitis that is associated with a high rate of mortality and morbidity. The establishment of antenatal screening and intrapartum chemoprophylaxis has led to a significant reduction in the incidence rate of invasive GBS disease in developed countries. However, these strategies are not routinely practiced in most developing countries. To ensure good recovery of infants affected with GBS, a prompt diagnostic strategy and appropriate therapy are essential. We highlight here the case of a preterm male infant diagnosed with early-onset of GBS meningitis diagnosed by using polymerase chain reaction (PCR) method on the cerebrospinal fluid (CSF) of the infant. Initially the pathogen was not isolated in both blood and CSF cultures as sampling was performed after the administration of antibiotics. Hence, PCR was a crucial diagnostic test in facilitating the detection of the pathogen in CSF. We believe that PCR is a potentially fast and precise diagnostic method for infection in a newborn. |
| first_indexed | 2024-03-06T11:04:18Z |
| format | Article |
| id | upm.eprints-96713 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T11:04:18Z |
| publishDate | 2021 |
| publisher | Malaysian Medical Association |
| record_format | dspace |
| spelling | upm.eprints-967132022-12-14T13:19:18Z http://psasir.upm.edu.my/id/eprint/96713/ Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction? Zainudin, Zurina Hoo, Nicole Phing Jie Amin Nordin, Syafinaz Sither Joseph Vesudian, Narcisse Mary Nunis, Melissa Anne Group B Streptococcus (GBS) is a predominant causative pathogen of neonatal meningitis that is associated with a high rate of mortality and morbidity. The establishment of antenatal screening and intrapartum chemoprophylaxis has led to a significant reduction in the incidence rate of invasive GBS disease in developed countries. However, these strategies are not routinely practiced in most developing countries. To ensure good recovery of infants affected with GBS, a prompt diagnostic strategy and appropriate therapy are essential. We highlight here the case of a preterm male infant diagnosed with early-onset of GBS meningitis diagnosed by using polymerase chain reaction (PCR) method on the cerebrospinal fluid (CSF) of the infant. Initially the pathogen was not isolated in both blood and CSF cultures as sampling was performed after the administration of antibiotics. Hence, PCR was a crucial diagnostic test in facilitating the detection of the pathogen in CSF. We believe that PCR is a potentially fast and precise diagnostic method for infection in a newborn. Malaysian Medical Association 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/96713/1/ABSTRACT.pdf Zainudin, Zurina and Hoo, Nicole Phing Jie and Amin Nordin, Syafinaz and Sither Joseph Vesudian, Narcisse Mary and Nunis, Melissa Anne (2021) Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction? Medical Journal of Malaysia, 76 (1). 101 - 102. ISSN 0300-5283 http://www.e-mjm.org/2021/v76n1 |
| spellingShingle | Zainudin, Zurina Hoo, Nicole Phing Jie Amin Nordin, Syafinaz Sither Joseph Vesudian, Narcisse Mary Nunis, Melissa Anne Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction? |
| title | Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction? |
| title_full | Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction? |
| title_fullStr | Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction? |
| title_full_unstemmed | Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction? |
| title_short | Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction? |
| title_sort | diagnosis of neonatal meningitis is it time to use polymerase chain reaction |
| url | http://psasir.upm.edu.my/id/eprint/96713/1/ABSTRACT.pdf |
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