Dual-functional iron oxide nanoparticles coated with polyvinyl alcohol/5-fluorouracil/zinc-aluminium-layered double hydroxide for a simultaneous drug and target delivery system
Iron oxide nanoparticles are suitable for biomedical applications owing to their ability to anchor to various active agents and drugs, unique magnetic properties, nontoxicity, and biocompatibility. In this work, the physico-chemical and magnetic properties, as well as the cytotoxicity, of Fe3O4 nano...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/96806/1/ABSTRACT.pdf |
| _version_ | 1825937767297712128 |
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| author | Ebadi, Mona Bullo, Saifullah Buskaran, Kalaivani Hussein, Mohd Zobir Fakurazi, Sharida Pastorin, Giorgia |
| author_facet | Ebadi, Mona Bullo, Saifullah Buskaran, Kalaivani Hussein, Mohd Zobir Fakurazi, Sharida Pastorin, Giorgia |
| author_sort | Ebadi, Mona |
| collection | UPM |
| description | Iron oxide nanoparticles are suitable for biomedical applications owing to their ability to anchor to various active agents and drugs, unique magnetic properties, nontoxicity, and biocompatibility. In this work, the physico-chemical and magnetic properties, as well as the cytotoxicity, of Fe3O4 nanoparticles coated with a polymeric carrier and loaded with a 5-fluorouracil (5-FU) anti-cancer drug are discussed. The synthesized Fe3O4 nanoparticles were coated with polyvinyl alcohol and Zn/Al-layered double hydroxide as the drug host. The XRD, DTA/TG, and FTIR analyzes confirmed the presence of the coating layer on the surface of nanoparticles. The results showed a decrease in saturation magnetization of bare Fe3O4 nanoparticles after coating with the PVA/5FU/Zn/Al-LDH layer. In addition, the presence of the coating prevented the agglomeration of nanoparticles. Furthermore, the pseudo-second-order equation governed the kinetics of drug release. Finally, the coated nanoparticles showed stronger activity against liver cancer cells (HepG2) compared to that of the naked 5-FU drug, and displayed no cytotoxicity towards 3T3 fibroblast cell lines. The results of the present study demonstrate the potential of a nano delivery system for cancer treatment. |
| first_indexed | 2024-03-06T11:04:31Z |
| format | Article |
| id | upm.eprints-96806 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T11:04:31Z |
| publishDate | 2021 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-968062022-12-01T04:15:17Z http://psasir.upm.edu.my/id/eprint/96806/ Dual-functional iron oxide nanoparticles coated with polyvinyl alcohol/5-fluorouracil/zinc-aluminium-layered double hydroxide for a simultaneous drug and target delivery system Ebadi, Mona Bullo, Saifullah Buskaran, Kalaivani Hussein, Mohd Zobir Fakurazi, Sharida Pastorin, Giorgia Iron oxide nanoparticles are suitable for biomedical applications owing to their ability to anchor to various active agents and drugs, unique magnetic properties, nontoxicity, and biocompatibility. In this work, the physico-chemical and magnetic properties, as well as the cytotoxicity, of Fe3O4 nanoparticles coated with a polymeric carrier and loaded with a 5-fluorouracil (5-FU) anti-cancer drug are discussed. The synthesized Fe3O4 nanoparticles were coated with polyvinyl alcohol and Zn/Al-layered double hydroxide as the drug host. The XRD, DTA/TG, and FTIR analyzes confirmed the presence of the coating layer on the surface of nanoparticles. The results showed a decrease in saturation magnetization of bare Fe3O4 nanoparticles after coating with the PVA/5FU/Zn/Al-LDH layer. In addition, the presence of the coating prevented the agglomeration of nanoparticles. Furthermore, the pseudo-second-order equation governed the kinetics of drug release. Finally, the coated nanoparticles showed stronger activity against liver cancer cells (HepG2) compared to that of the naked 5-FU drug, and displayed no cytotoxicity towards 3T3 fibroblast cell lines. The results of the present study demonstrate the potential of a nano delivery system for cancer treatment. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/96806/1/ABSTRACT.pdf Ebadi, Mona and Bullo, Saifullah and Buskaran, Kalaivani and Hussein, Mohd Zobir and Fakurazi, Sharida and Pastorin, Giorgia (2021) Dual-functional iron oxide nanoparticles coated with polyvinyl alcohol/5-fluorouracil/zinc-aluminium-layered double hydroxide for a simultaneous drug and target delivery system. Polymers, 13 (6). pp. 1-18. ISSN 2073-4360 https://www.mdpi.com/2073-4360/13/6/855 10.3390/polym13060855 |
| spellingShingle | Ebadi, Mona Bullo, Saifullah Buskaran, Kalaivani Hussein, Mohd Zobir Fakurazi, Sharida Pastorin, Giorgia Dual-functional iron oxide nanoparticles coated with polyvinyl alcohol/5-fluorouracil/zinc-aluminium-layered double hydroxide for a simultaneous drug and target delivery system |
| title | Dual-functional iron oxide nanoparticles coated with polyvinyl alcohol/5-fluorouracil/zinc-aluminium-layered double hydroxide for a simultaneous drug and target delivery system |
| title_full | Dual-functional iron oxide nanoparticles coated with polyvinyl alcohol/5-fluorouracil/zinc-aluminium-layered double hydroxide for a simultaneous drug and target delivery system |
| title_fullStr | Dual-functional iron oxide nanoparticles coated with polyvinyl alcohol/5-fluorouracil/zinc-aluminium-layered double hydroxide for a simultaneous drug and target delivery system |
| title_full_unstemmed | Dual-functional iron oxide nanoparticles coated with polyvinyl alcohol/5-fluorouracil/zinc-aluminium-layered double hydroxide for a simultaneous drug and target delivery system |
| title_short | Dual-functional iron oxide nanoparticles coated with polyvinyl alcohol/5-fluorouracil/zinc-aluminium-layered double hydroxide for a simultaneous drug and target delivery system |
| title_sort | dual functional iron oxide nanoparticles coated with polyvinyl alcohol 5 fluorouracil zinc aluminium layered double hydroxide for a simultaneous drug and target delivery system |
| url | http://psasir.upm.edu.my/id/eprint/96806/1/ABSTRACT.pdf |
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