Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters
The potential of producing L-isoleucine crystals with the aid of electric potential and its effect on the nucleation kinetics of L-isoleucine were probed using polythermal and isothermal crystallisation techniques, assisted with 5 V, 9 V, and 20 V electric potentials. The polythermal experiments wer...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/97048/1/ABSTRACT.pdf |
| _version_ | 1796983332706189312 |
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| author | Md Azmi, Nik Salwani Anuar, Nornizar Othman, Muhamad Fitri Abu Bakar, Noor Fitrah Naim, Mohd Nazli |
| author_facet | Md Azmi, Nik Salwani Anuar, Nornizar Othman, Muhamad Fitri Abu Bakar, Noor Fitrah Naim, Mohd Nazli |
| author_sort | Md Azmi, Nik Salwani |
| collection | UPM |
| description | The potential of producing L-isoleucine crystals with the aid of electric potential and its effect on the nucleation kinetics of L-isoleucine were probed using polythermal and isothermal crystallisation techniques, assisted with 5 V, 9 V, and 20 V electric potentials. The polythermal experiments were conducted with cooling rates of 0.1 °C/min–0.7 °C/min, whilst isothermal crystallisation was conducted with a supersaturation of 1.30–1.70, and both were carried out in a 200 mL temperature-controlled jacketed reactor. Prediction of the nucleation rate and its associated parameters for isothermal crystallisation was carried out using a molecular dynamics simulation. In both crystallisation techniques, electric potentials increased the nucleation rate, but the intensity of the electric potential had less impact on the measured parameters. Nucleation rates for 5 V isothermal crystallisation were in the order of 1010 higher than for polythermal crystallisation. Electric potential doubled the nucleation rates for polythermal crystallisation and increased the nucleation rates 12-fold in isothermal crystallisation. The isothermal technique produced the form B polymorph, but mixtures of forms A and B were produced in polythermal crystallisation. The predicted critical number of molecules, N*, and the critical radius, r*, were in good agreement with the experimental data, with a higher predicted nucleation rate in the order of 102 |
| first_indexed | 2024-03-06T11:05:04Z |
| format | Article |
| id | upm.eprints-97048 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T11:05:04Z |
| publishDate | 2021 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-970482022-10-15T15:44:15Z http://psasir.upm.edu.my/id/eprint/97048/ Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters Md Azmi, Nik Salwani Anuar, Nornizar Othman, Muhamad Fitri Abu Bakar, Noor Fitrah Naim, Mohd Nazli The potential of producing L-isoleucine crystals with the aid of electric potential and its effect on the nucleation kinetics of L-isoleucine were probed using polythermal and isothermal crystallisation techniques, assisted with 5 V, 9 V, and 20 V electric potentials. The polythermal experiments were conducted with cooling rates of 0.1 °C/min–0.7 °C/min, whilst isothermal crystallisation was conducted with a supersaturation of 1.30–1.70, and both were carried out in a 200 mL temperature-controlled jacketed reactor. Prediction of the nucleation rate and its associated parameters for isothermal crystallisation was carried out using a molecular dynamics simulation. In both crystallisation techniques, electric potentials increased the nucleation rate, but the intensity of the electric potential had less impact on the measured parameters. Nucleation rates for 5 V isothermal crystallisation were in the order of 1010 higher than for polythermal crystallisation. Electric potential doubled the nucleation rates for polythermal crystallisation and increased the nucleation rates 12-fold in isothermal crystallisation. The isothermal technique produced the form B polymorph, but mixtures of forms A and B were produced in polythermal crystallisation. The predicted critical number of molecules, N*, and the critical radius, r*, were in good agreement with the experimental data, with a higher predicted nucleation rate in the order of 102 Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97048/1/ABSTRACT.pdf Md Azmi, Nik Salwani and Anuar, Nornizar and Othman, Muhamad Fitri and Abu Bakar, Noor Fitrah and Naim, Mohd Nazli (2021) Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters. Crystals, 11 (6). art. no. 620. pp. 1-20. ISSN 2073-4352 https://www.mdpi.com/2073-4352/11/6/620 10.3390/cryst11060620 |
| spellingShingle | Md Azmi, Nik Salwani Anuar, Nornizar Othman, Muhamad Fitri Abu Bakar, Noor Fitrah Naim, Mohd Nazli Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters |
| title | Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters |
| title_full | Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters |
| title_fullStr | Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters |
| title_full_unstemmed | Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters |
| title_short | Electric-potential-assisted crystallisation of L-isoleucine: a study of nucleation kinetics and its associated parameters |
| title_sort | electric potential assisted crystallisation of l isoleucine a study of nucleation kinetics and its associated parameters |
| url | http://psasir.upm.edu.my/id/eprint/97048/1/ABSTRACT.pdf |
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