Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride
In this study, electrochemical characterization and detection of an anti-inflammatory drug diclofenac (DCF) and a local anesthetic drug dibucaine (DIC) at synthetic saliva|1,6- dichlorohexane interface were carried out for the first time using cyclic voltammetry (CV) and differential pulse voltammet...
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| Format: | Article |
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ESG
2021
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| author | Mohamed Almbrok, Eissa Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza |
| author_facet | Mohamed Almbrok, Eissa Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza |
| author_sort | Mohamed Almbrok, Eissa |
| collection | UPM |
| description | In this study, electrochemical characterization and detection of an anti-inflammatory drug diclofenac (DCF) and a local anesthetic drug dibucaine (DIC) at synthetic saliva|1,6- dichlorohexane interface were carried out for the first time using cyclic voltammetry (CV) and differential pulse voltammetry (DPV).
Although the CV of synthetic saliva matrix slightly decreased the available potential window at the micro-ITIES, it has no significant effect on the ion-transfer voltammetry of DCF and DIC at liquid|liquid interface. Peak currents response by DPV were linearly increased with both DCF and DIC concentrations in the synthetic saliva matrix over the concentrations ranged 8–40 μmol L-1
and 8–24 μmol L-1, and the calculated detection limits were 1.8 ± 0.2 μmol L-1 and 1.5 ± 0.14 μmol L-1, respectively. These results
demonstrated that DPV at liquid|liquid micro interfaces arrays is a feasible analytical method for ionizable drugs detection in biomimetic matrixes. |
| first_indexed | 2024-03-06T11:05:05Z |
| format | Article |
| id | upm.eprints-97052 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T11:05:05Z |
| publishDate | 2021 |
| publisher | ESG |
| record_format | dspace |
| spelling | upm.eprints-970522023-04-19T04:07:08Z http://psasir.upm.edu.my/id/eprint/97052/ Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride Mohamed Almbrok, Eissa Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza In this study, electrochemical characterization and detection of an anti-inflammatory drug diclofenac (DCF) and a local anesthetic drug dibucaine (DIC) at synthetic saliva|1,6- dichlorohexane interface were carried out for the first time using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Although the CV of synthetic saliva matrix slightly decreased the available potential window at the micro-ITIES, it has no significant effect on the ion-transfer voltammetry of DCF and DIC at liquid|liquid interface. Peak currents response by DPV were linearly increased with both DCF and DIC concentrations in the synthetic saliva matrix over the concentrations ranged 8–40 μmol L-1 and 8–24 μmol L-1, and the calculated detection limits were 1.8 ± 0.2 μmol L-1 and 1.5 ± 0.14 μmol L-1, respectively. These results demonstrated that DPV at liquid|liquid micro interfaces arrays is a feasible analytical method for ionizable drugs detection in biomimetic matrixes. ESG 2021 Article PeerReviewed Mohamed Almbrok, Eissa and Yusof, Nor Azah and Abdullah, Jaafar and Mohd Zawawi, Ruzniza (2021) Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride. International Journal of Electrochemical Science, 16. pp. 1-11. ISSN 1452-3981 http://www.electrochemsci.org/list21.htm 10.20964/2021.12.54 |
| spellingShingle | Mohamed Almbrok, Eissa Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride |
| title | Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride |
| title_full | Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride |
| title_fullStr | Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride |
| title_full_unstemmed | Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride |
| title_short | Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride |
| title_sort | electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid liquid micro interface modified by silicon nitride |
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