'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors
Dietary pattern (DP) and its relationship with disease biomarkers have received recognition in nutritional epidemiology investigations. However, DP relationships with adipokines (i.e., adiponectin and leptin) among breast cancer survivors remain unclear. Therefore, we assessed relationships between...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/97076/1/ABSTRACT.pdf |
| _version_ | 1825937808340025344 |
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| author | Shahril, Mohd Razif Zakarai, Nor Syamimi Appannah, Geeta Nurnazahiah, Ali Jan Mohamed, Hamid Jan Ahmad, Aryati Pei, Lin Lua Fenech, Michael |
| author_facet | Shahril, Mohd Razif Zakarai, Nor Syamimi Appannah, Geeta Nurnazahiah, Ali Jan Mohamed, Hamid Jan Ahmad, Aryati Pei, Lin Lua Fenech, Michael |
| author_sort | Shahril, Mohd Razif |
| collection | UPM |
| description | Dietary pattern (DP) and its relationship with disease biomarkers have received recognition in nutritional epidemiology investigations. However, DP relationships with adipokines (i.e., adiponectin and leptin) among breast cancer survivors remain unclear. Therefore, we assessed relationships between DP and high-molecular weight (HMW) adiponectin and leptin concentration among breast cancer survivors. This cross-sectional study involved 128 breast cancer survivors who attended the oncology outpatient clinic at two main government hospitals in the East Coast of Peninsular Malaysia. The serum concentration of HMW adiponectin and leptin were measured using enzyme-linked immunosorbent assay (ELISA) kits. A reduced rank regression method was used to analyze DP. Relationships between DP with HMW adiponectin and leptin were examined using regression models. The findings show that with every 1-unit increase in the ‘energy-dense, high-SFA, low-fiber’ DP z-score, there was a reduction by 0.41 μg/mL in HMW adiponectin which was independent of age, BMI, education level, occupation status, cancer stage, and duration since diagnosis. A similar relationship with leptin concentration was not observed. In conclusion, the ‘energy-dense, high-saturated fat and low-fiber’ DP, which is characterized by high intake levels of sugar-sweetened drinks and fat-based spreads but low intake of fruits and vegetables, is an unhealthy dietary pattern and unfavorable for HMW adiponectin concentration, but not for leptin. These findings could serve as a basis in developing specific preventive strategies that are tailored to the growing population of breast cancer survivors. |
| first_indexed | 2024-03-06T11:05:09Z |
| format | Article |
| id | upm.eprints-97076 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T11:05:09Z |
| publishDate | 2021 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | upm.eprints-970762022-10-17T02:05:51Z http://psasir.upm.edu.my/id/eprint/97076/ 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors Shahril, Mohd Razif Zakarai, Nor Syamimi Appannah, Geeta Nurnazahiah, Ali Jan Mohamed, Hamid Jan Ahmad, Aryati Pei, Lin Lua Fenech, Michael Dietary pattern (DP) and its relationship with disease biomarkers have received recognition in nutritional epidemiology investigations. However, DP relationships with adipokines (i.e., adiponectin and leptin) among breast cancer survivors remain unclear. Therefore, we assessed relationships between DP and high-molecular weight (HMW) adiponectin and leptin concentration among breast cancer survivors. This cross-sectional study involved 128 breast cancer survivors who attended the oncology outpatient clinic at two main government hospitals in the East Coast of Peninsular Malaysia. The serum concentration of HMW adiponectin and leptin were measured using enzyme-linked immunosorbent assay (ELISA) kits. A reduced rank regression method was used to analyze DP. Relationships between DP with HMW adiponectin and leptin were examined using regression models. The findings show that with every 1-unit increase in the ‘energy-dense, high-SFA, low-fiber’ DP z-score, there was a reduction by 0.41 μg/mL in HMW adiponectin which was independent of age, BMI, education level, occupation status, cancer stage, and duration since diagnosis. A similar relationship with leptin concentration was not observed. In conclusion, the ‘energy-dense, high-saturated fat and low-fiber’ DP, which is characterized by high intake levels of sugar-sweetened drinks and fat-based spreads but low intake of fruits and vegetables, is an unhealthy dietary pattern and unfavorable for HMW adiponectin concentration, but not for leptin. These findings could serve as a basis in developing specific preventive strategies that are tailored to the growing population of breast cancer survivors. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97076/1/ABSTRACT.pdf Shahril, Mohd Razif and Zakarai, Nor Syamimi and Appannah, Geeta and Nurnazahiah, Ali and Jan Mohamed, Hamid Jan and Ahmad, Aryati and Pei, Lin Lua and Fenech, Michael (2021) 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors. Nutrients, 13 (10). art. no. 3339. pp. 1-12. ISSN 2072-6643 https://www.mdpi.com/2072-6643/13/10/3339 10.3390/nu13103339 |
| spellingShingle | Shahril, Mohd Razif Zakarai, Nor Syamimi Appannah, Geeta Nurnazahiah, Ali Jan Mohamed, Hamid Jan Ahmad, Aryati Pei, Lin Lua Fenech, Michael 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors |
| title | 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors |
| title_full | 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors |
| title_fullStr | 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors |
| title_full_unstemmed | 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors |
| title_short | 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors |
| title_sort | energy dense high sfa and low fiber dietary pattern lowered adiponectin but not leptin concentration of breast cancer survivors |
| url | http://psasir.upm.edu.my/id/eprint/97076/1/ABSTRACT.pdf |
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