Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers
MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their abi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Physiological Society
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/97196/1/ABSTRACT.pdf |
| _version_ | 1796983361254719488 |
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| author | Tan, Pei Paulina Suu Hall, Deborah Chilian, William M. Yook, Chin Chia Mohd Zain, Shamsul Hooi, Min Lim Kumar, Devaraj Navin Ching, Siew Mooi Teck, Yew Low Md Noh, Mohd Fairulnizal Yuh, Fen Pung |
| author_facet | Tan, Pei Paulina Suu Hall, Deborah Chilian, William M. Yook, Chin Chia Mohd Zain, Shamsul Hooi, Min Lim Kumar, Devaraj Navin Ching, Siew Mooi Teck, Yew Low Md Noh, Mohd Fairulnizal Yuh, Fen Pung |
| author_sort | Tan, Pei Paulina Suu |
| collection | UPM |
| description | MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their ability to withstand harsh external conditions, exosomal miRNAs possess enormous potential as noninvasive disease biomarkers for, notably hypertension, whereby exosomal miRNAs have been implicated in its pathophysiological processes. More importantly, alterations in the microenvironment as a result of disease progression can induce active and selective loading of miRNAs into exosomes. In this paper, we first review the mechanisms of miRNA loading into exosomes, followed by the roles of exosomal miRNAs in the development of hypertension, and the potentials of exosomal miRNAs as biomarkers in comparison with other free circulating miRNAs. Finally, challenges and future research surrounding exosomal miRNAs will also be discussed. This review will aid in the understanding of noninvasive biomarkers for the early diagnosis of hypertension and for probing therapeutic efficacy. |
| first_indexed | 2024-03-06T11:05:26Z |
| format | Article |
| id | upm.eprints-97196 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T11:05:26Z |
| publishDate | 2021 |
| publisher | American Physiological Society |
| record_format | dspace |
| spelling | upm.eprints-971962022-09-13T08:55:28Z http://psasir.upm.edu.my/id/eprint/97196/ Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers Tan, Pei Paulina Suu Hall, Deborah Chilian, William M. Yook, Chin Chia Mohd Zain, Shamsul Hooi, Min Lim Kumar, Devaraj Navin Ching, Siew Mooi Teck, Yew Low Md Noh, Mohd Fairulnizal Yuh, Fen Pung MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their ability to withstand harsh external conditions, exosomal miRNAs possess enormous potential as noninvasive disease biomarkers for, notably hypertension, whereby exosomal miRNAs have been implicated in its pathophysiological processes. More importantly, alterations in the microenvironment as a result of disease progression can induce active and selective loading of miRNAs into exosomes. In this paper, we first review the mechanisms of miRNA loading into exosomes, followed by the roles of exosomal miRNAs in the development of hypertension, and the potentials of exosomal miRNAs as biomarkers in comparison with other free circulating miRNAs. Finally, challenges and future research surrounding exosomal miRNAs will also be discussed. This review will aid in the understanding of noninvasive biomarkers for the early diagnosis of hypertension and for probing therapeutic efficacy. American Physiological Society 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97196/1/ABSTRACT.pdf Tan, Pei Paulina Suu and Hall, Deborah and Chilian, William M. and Yook, Chin Chia and Mohd Zain, Shamsul and Hooi, Min Lim and Kumar, Devaraj Navin and Ching, Siew Mooi and Teck, Yew Low and Md Noh, Mohd Fairulnizal and Yuh, Fen Pung (2021) Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers. American Journal of Physiology - Heart and Circulatory Physiology, 320. pp. 486-497. ISSN 0363-6135; ESSN: 1522-1539 https://journals.physiology.org/doi/full/10.1152/ajpheart.00888.2020?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org 10.1152/ajpheart.00888.2020 |
| spellingShingle | Tan, Pei Paulina Suu Hall, Deborah Chilian, William M. Yook, Chin Chia Mohd Zain, Shamsul Hooi, Min Lim Kumar, Devaraj Navin Ching, Siew Mooi Teck, Yew Low Md Noh, Mohd Fairulnizal Yuh, Fen Pung Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers |
| title | Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers |
| title_full | Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers |
| title_fullStr | Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers |
| title_full_unstemmed | Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers |
| title_short | Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers |
| title_sort | exosomal micrornas in the development of essential hypertension and its potential as biomarkers |
| url | http://psasir.upm.edu.my/id/eprint/97196/1/ABSTRACT.pdf |
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