Susceptibility profiles of bacterial pathogens causing community-acquired urinary tract infections
Introduction: Uncontrolled empirical treatment of urinary tract infections (UTIs) has negative aspect on predict- ing the emergence of antimicrobial resistance and knowledge of those patterns has become extremely important from time to time. Therefore, the aim of the present study was to check the p...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2021
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/98082/1/2021100809363601_MJMHS_1034.pdf |
| _version_ | 1825937983980699648 |
|---|---|
| author | Atshan, Salman Sahab Salah, Zohier B Al-Zihiry, Khalid Jameel Kadhim Ali A., Alreshidi Mateq Hamat, Rukman Awang |
| author_facet | Atshan, Salman Sahab Salah, Zohier B Al-Zihiry, Khalid Jameel Kadhim Ali A., Alreshidi Mateq Hamat, Rukman Awang |
| author_sort | Atshan, Salman Sahab |
| collection | UPM |
| description | Introduction: Uncontrolled empirical treatment of urinary tract infections (UTIs) has negative aspect on predict- ing the emergence of antimicrobial resistance and knowledge of those patterns has become extremely important from time to time. Therefore, the aim of the present study was to check the prevalence and resistance patterns of uropathogens in the community acquired UTIs. Methods: A total of 7132 urine samples were combined from male 3131 (43.9%) and female 4001 (56.1%) outpatients suspected of having UTIs, respectively over a three-year period and cultured on routine culture media. The bacteria have been identified using basic biochemical tests, and sen- sitivity to various antibiotics was determined by the method of disk diffusion. Results: Of 7132 urine samples 797 (11.2%) yielded significant uropathogens. Among the bacterial species, Escherichia coli was the major causative agent of UTIs for both gender (63.7%), followed by Klebsiella spp (20.8%), Enterococcus faecalis (5.3%), Pseudo- monas spp (4.1%), Proteus spp (3.1%), Enterobacter spp (1.5%), Candida albicans (0.6%), Staphylococcus sapro- phyticus (0.5%), Providencia spp (0.1%) and Staphylococcus aureus (0.1%). The antibacterial sensitivity testing for E. coli, to commonly used antibiotics were showed variable resistant as follows: Ampicilln (78%), Amoxicillin (71%), trimethoprim sulfamethoxazole (42%), Amox/clav. (14%) gentamicin (20%), nitrofurantoin (11%), nalidixic acid (22%), ciprofloxacin (20%), Imipenem (16%),Ceftazidim (26%),Cefotaxim (25%),Ceftriaxon (21%),Cefuroxim (33%). Conclusions: The findings showed that antimicrobial resistance patterns of uropathogens in variable, and continuous monitoring of resistance patterns by using of antibiotic susceptibility testing in the laboratory is the most appropriate to treat UTIs rather than the choice of UTIs empirical treatment. |
| first_indexed | 2024-03-06T11:07:40Z |
| format | Article |
| id | upm.eprints-98082 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T11:07:40Z |
| publishDate | 2021 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-980822022-08-11T03:28:40Z http://psasir.upm.edu.my/id/eprint/98082/ Susceptibility profiles of bacterial pathogens causing community-acquired urinary tract infections Atshan, Salman Sahab Salah, Zohier B Al-Zihiry, Khalid Jameel Kadhim Ali A., Alreshidi Mateq Hamat, Rukman Awang Introduction: Uncontrolled empirical treatment of urinary tract infections (UTIs) has negative aspect on predict- ing the emergence of antimicrobial resistance and knowledge of those patterns has become extremely important from time to time. Therefore, the aim of the present study was to check the prevalence and resistance patterns of uropathogens in the community acquired UTIs. Methods: A total of 7132 urine samples were combined from male 3131 (43.9%) and female 4001 (56.1%) outpatients suspected of having UTIs, respectively over a three-year period and cultured on routine culture media. The bacteria have been identified using basic biochemical tests, and sen- sitivity to various antibiotics was determined by the method of disk diffusion. Results: Of 7132 urine samples 797 (11.2%) yielded significant uropathogens. Among the bacterial species, Escherichia coli was the major causative agent of UTIs for both gender (63.7%), followed by Klebsiella spp (20.8%), Enterococcus faecalis (5.3%), Pseudo- monas spp (4.1%), Proteus spp (3.1%), Enterobacter spp (1.5%), Candida albicans (0.6%), Staphylococcus sapro- phyticus (0.5%), Providencia spp (0.1%) and Staphylococcus aureus (0.1%). The antibacterial sensitivity testing for E. coli, to commonly used antibiotics were showed variable resistant as follows: Ampicilln (78%), Amoxicillin (71%), trimethoprim sulfamethoxazole (42%), Amox/clav. (14%) gentamicin (20%), nitrofurantoin (11%), nalidixic acid (22%), ciprofloxacin (20%), Imipenem (16%),Ceftazidim (26%),Cefotaxim (25%),Ceftriaxon (21%),Cefuroxim (33%). Conclusions: The findings showed that antimicrobial resistance patterns of uropathogens in variable, and continuous monitoring of resistance patterns by using of antibiotic susceptibility testing in the laboratory is the most appropriate to treat UTIs rather than the choice of UTIs empirical treatment. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2021-10 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/98082/1/2021100809363601_MJMHS_1034.pdf Atshan, Salman Sahab and Salah, Zohier B and Al-Zihiry, Khalid Jameel Kadhim and Ali A., Alreshidi Mateq and Hamat, Rukman Awang (2021) Susceptibility profiles of bacterial pathogens causing community-acquired urinary tract infections. Malaysian Journal of Medicine and Health Sciences, 17 (4). pp. 3-7. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2021100809363601_MJMHS_1034.pdf |
| spellingShingle | Atshan, Salman Sahab Salah, Zohier B Al-Zihiry, Khalid Jameel Kadhim Ali A., Alreshidi Mateq Hamat, Rukman Awang Susceptibility profiles of bacterial pathogens causing community-acquired urinary tract infections |
| title | Susceptibility profiles of bacterial pathogens causing community-acquired urinary tract infections |
| title_full | Susceptibility profiles of bacterial pathogens causing community-acquired urinary tract infections |
| title_fullStr | Susceptibility profiles of bacterial pathogens causing community-acquired urinary tract infections |
| title_full_unstemmed | Susceptibility profiles of bacterial pathogens causing community-acquired urinary tract infections |
| title_short | Susceptibility profiles of bacterial pathogens causing community-acquired urinary tract infections |
| title_sort | susceptibility profiles of bacterial pathogens causing community acquired urinary tract infections |
| url | http://psasir.upm.edu.my/id/eprint/98082/1/2021100809363601_MJMHS_1034.pdf |
| work_keys_str_mv | AT atshansalmansahab susceptibilityprofilesofbacterialpathogenscausingcommunityacquiredurinarytractinfections AT salahzohierb susceptibilityprofilesofbacterialpathogenscausingcommunityacquiredurinarytractinfections AT alzihirykhalidjameelkadhim susceptibilityprofilesofbacterialpathogenscausingcommunityacquiredurinarytractinfections AT aliaalreshidimateq susceptibilityprofilesofbacterialpathogenscausingcommunityacquiredurinarytractinfections AT hamatrukmanawang susceptibilityprofilesofbacterialpathogenscausingcommunityacquiredurinarytractinfections |