Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients

Introduction: Suboptimal vitamin D levels are commonly presented by systemic lupus erythemathosus (SLE) patients. This is likely due to protection measures from sunshine exposure adopted by SLE patients to reduce the likelihood of SLE flares onset. In this study, we investigated the vitamin D level...

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Main Authors: Ibrahim, Izzaidah, Wan Mohamed, Wan Mohd Izani, Kah, Keng Wong, Tuan Ismail, Tuan Salwani, Wan Ghazali, Wan Syamimee
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022
Online Access:http://psasir.upm.edu.my/id/eprint/98128/1/2022031418332104_MJMHS_0766.pdf
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author Ibrahim, Izzaidah
Wan Mohamed, Wan Mohd Izani
Kah, Keng Wong
Tuan Ismail, Tuan Salwani
Wan Ghazali, Wan Syamimee
author_facet Ibrahim, Izzaidah
Wan Mohamed, Wan Mohd Izani
Kah, Keng Wong
Tuan Ismail, Tuan Salwani
Wan Ghazali, Wan Syamimee
author_sort Ibrahim, Izzaidah
collection UPM
description Introduction: Suboptimal vitamin D levels are commonly presented by systemic lupus erythemathosus (SLE) patients. This is likely due to protection measures from sunshine exposure adopted by SLE patients to reduce the likelihood of SLE flares onset. In this study, we investigated the vitamin D level among SLE patients and its association with SLE Disease Activity (SLEDAI) scores and among groups of steroid and non-steroid usage. Methods: We recruited 84 SLE patients who attended the Rheumatology Clinic of Hospital Universiti Sains Malaysia from June 2018 until October 2018. Their clinico-demographic data were retrieved and serum vitamin D immunoassay was conducted to measure the vitamin D levels of each patient Vitamin D levels were categorized as normal (≥75nmol/L), insufficient (50-74 nmol/L) or deficient (<50 nmol/L). Comparison between the clinico-demographic parameters with vitamin D levels were conducted using the Fisher’s exact test (for categorical variables) and unpaired t-test (for continuous variables). Results: The mean vitamin D level among the subjects was 40.79 ± 20.2 nmol/L. Fifty-eight (69%) patients were vitamin D deficient, while 20 (23.8%) patients were vitamin D insufficient, and only 6 (7.1%) patients had sufficient level of vitamin D. Vitamin D status was not significantly associated with SLEDAI score (p=0.185) as well as between steroids and non-steroids groups (p=0.255). Conclusion: Vitamin D deficiency occurred in majority of our SLE patients. SLE disease activities were not associated with the status of vitamin D or steroid usage.
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spelling upm.eprints-981282022-08-11T08:29:11Z http://psasir.upm.edu.my/id/eprint/98128/ Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients Ibrahim, Izzaidah Wan Mohamed, Wan Mohd Izani Kah, Keng Wong Tuan Ismail, Tuan Salwani Wan Ghazali, Wan Syamimee Introduction: Suboptimal vitamin D levels are commonly presented by systemic lupus erythemathosus (SLE) patients. This is likely due to protection measures from sunshine exposure adopted by SLE patients to reduce the likelihood of SLE flares onset. In this study, we investigated the vitamin D level among SLE patients and its association with SLE Disease Activity (SLEDAI) scores and among groups of steroid and non-steroid usage. Methods: We recruited 84 SLE patients who attended the Rheumatology Clinic of Hospital Universiti Sains Malaysia from June 2018 until October 2018. Their clinico-demographic data were retrieved and serum vitamin D immunoassay was conducted to measure the vitamin D levels of each patient Vitamin D levels were categorized as normal (≥75nmol/L), insufficient (50-74 nmol/L) or deficient (<50 nmol/L). Comparison between the clinico-demographic parameters with vitamin D levels were conducted using the Fisher’s exact test (for categorical variables) and unpaired t-test (for continuous variables). Results: The mean vitamin D level among the subjects was 40.79 ± 20.2 nmol/L. Fifty-eight (69%) patients were vitamin D deficient, while 20 (23.8%) patients were vitamin D insufficient, and only 6 (7.1%) patients had sufficient level of vitamin D. Vitamin D status was not significantly associated with SLEDAI score (p=0.185) as well as between steroids and non-steroids groups (p=0.255). Conclusion: Vitamin D deficiency occurred in majority of our SLE patients. SLE disease activities were not associated with the status of vitamin D or steroid usage. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022-03 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/98128/1/2022031418332104_MJMHS_0766.pdf Ibrahim, Izzaidah and Wan Mohamed, Wan Mohd Izani and Kah, Keng Wong and Tuan Ismail, Tuan Salwani and Wan Ghazali, Wan Syamimee (2022) Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients. Malaysian Journal of Medicine and Health Sciences, 18 (2). pp. 20-25. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2022031418332104_MJMHS_0766.pdf
spellingShingle Ibrahim, Izzaidah
Wan Mohamed, Wan Mohd Izani
Kah, Keng Wong
Tuan Ismail, Tuan Salwani
Wan Ghazali, Wan Syamimee
Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title_full Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title_fullStr Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title_full_unstemmed Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title_short Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title_sort vitamin d levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
url http://psasir.upm.edu.my/id/eprint/98128/1/2022031418332104_MJMHS_0766.pdf
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