Mitochondrial redox modulation of NLRP3 inflammasome in differentiated THP-1 cells
Introduction: Innate host defence against pathogen required NLRP3 inflammasome activation. Two steps of inflammasome complex activation are identified: Signal 1 or priming (expression of NLRP3 protein, pro-IL-1β, pro-IL-18 and pro-caspase-1), followed by Signal 2 or activation (expression of active...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Published: |
Universiti Putra Malaysia
2019
|