Molecular Cloning, Expression, And Characterization Of Glutathione-Stransferase As A Novel Target In Antimalarial Drug Design And Discovery

Molecular Cloning, Expression, And Characterization Of Glutathione-Stransferase As A Novel Target In Antimalarial Drug Design And Discovery

Glutation-S-transferase (GSTs) adalah sekumpulan enzim detoksifikasi. Plasmodium falciparum mempunyai isoform tunggal GST (PfGST) yang terlibat dalam bagi detoksifikasi heme. The Glutathione-S-transferases (GSTs) are group of detoxification enzymes. Plasmodium falciparum has a single isoform o...

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Bibliographic Details
Main Author: Al-Qattan, Mohammed Nooraldeen Mahmod
Format: Thesis
Language:English
Published: 2015
Subjects:
QH1 Natural history (General - Including nature conservation, geographical distribution)
Online Access:http://eprints.usm.my/30219/1/PhD_thesis_Mohammed_Nooraldeen_Mahmod_march_2015.pdf
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Summary:Glutation-S-transferase (GSTs) adalah sekumpulan enzim detoksifikasi. Plasmodium falciparum mempunyai isoform tunggal GST (PfGST) yang terlibat dalam bagi detoksifikasi heme. The Glutathione-S-transferases (GSTs) are group of detoxification enzymes. Plasmodium falciparum has a single isoform of GST (PfGST) that involves in heme detoxification. While other GSTs isoforms from human (hGSTP1) and mouse (mGSTM1) are involved in apoptotic stress kinase pathway and mediate cancer cell resistance to chemotherapy.

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