Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action
Anti-diabetic activity guided studies were performed on the leaves of Syzygium polyanthum, a popular traditional medicinal herb in north Sumatera, Indonesia. The anti-diabetic activity was evaluated by determining whether the extracts lowered the blood glucose levels (BGL) of normal rats (hypoglycae...
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| Format: | Thesis |
| Language: | English |
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2015
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| Online Access: | http://eprints.usm.my/30395/1/TRI_WIDYAWATI.pdf |
| _version_ | 1825832381048684544 |
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| author | Tri, Widyawati |
| author_facet | Tri, Widyawati |
| author_sort | Tri, Widyawati |
| collection | USM |
| description | Anti-diabetic activity guided studies were performed on the leaves of Syzygium polyanthum, a popular traditional medicinal herb in north Sumatera, Indonesia. The anti-diabetic activity was evaluated by determining whether the extracts lowered the blood glucose levels (BGL) of normal rats (hypoglycaemic test), inhibited the rise of BGL of intraperitoneally glucose- loaded rats (glucose tolerance test) and lowered BGL of streptozotocin-induced diabetic rats. Dried powdered S. polyanthum leaves were extracted serially with petroleum ether (PEE), chloroform (CE), methanol (ME) and water (WE). In diabetic rats, single-dose administration of the extracts showed that only ME reduced BGL. However, upon repeated-dose administration for 6 days both PEE and ME reduced BGL significantly. Therefore, liquid-liquid partition was used to fractionate ME into the following fractions: chloroform (CF), ethyl acetate (EAF), n-butanol (n-BF) and water (WF). Repeated administration of CF and WF decreased BGL of diabetic rats. CF was shaken with n-hexane to yield an undissolved fraction (SF-1) and a dissolved fraction (SF-2). |
| first_indexed | 2024-03-06T14:51:59Z |
| format | Thesis |
| id | usm.eprints-30395 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T14:51:59Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | usm.eprints-303952019-04-12T05:25:56Z http://eprints.usm.my/30395/ Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action Tri, Widyawati RS1-441 Pharmacy and materia medica Anti-diabetic activity guided studies were performed on the leaves of Syzygium polyanthum, a popular traditional medicinal herb in north Sumatera, Indonesia. The anti-diabetic activity was evaluated by determining whether the extracts lowered the blood glucose levels (BGL) of normal rats (hypoglycaemic test), inhibited the rise of BGL of intraperitoneally glucose- loaded rats (glucose tolerance test) and lowered BGL of streptozotocin-induced diabetic rats. Dried powdered S. polyanthum leaves were extracted serially with petroleum ether (PEE), chloroform (CE), methanol (ME) and water (WE). In diabetic rats, single-dose administration of the extracts showed that only ME reduced BGL. However, upon repeated-dose administration for 6 days both PEE and ME reduced BGL significantly. Therefore, liquid-liquid partition was used to fractionate ME into the following fractions: chloroform (CF), ethyl acetate (EAF), n-butanol (n-BF) and water (WF). Repeated administration of CF and WF decreased BGL of diabetic rats. CF was shaken with n-hexane to yield an undissolved fraction (SF-1) and a dissolved fraction (SF-2). 2015 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/30395/1/TRI_WIDYAWATI.pdf Tri, Widyawati (2015) Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Tri, Widyawati Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action |
| title | Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action |
| title_full | Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action |
| title_fullStr | Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action |
| title_full_unstemmed | Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action |
| title_short | Anti-Diabetic Activity-Guided Studies Of Syzygium Polyanthum (Wight) Leaf Extracts And Elucidation Of Their Mechanisms Of Action |
| title_sort | anti diabetic activity guided studies of syzygium polyanthum wight leaf extracts and elucidation of their mechanisms of action |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/30395/1/TRI_WIDYAWATI.pdf |
| work_keys_str_mv | AT triwidyawati antidiabeticactivityguidedstudiesofsyzygiumpolyanthumwightleafextractsandelucidationoftheirmechanismsofaction |