Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form
Satisfactory spherical pellets were successfully· prepared by the process of extrusionlspheronization using the excipient microcrystalline cellulose (IvrCC) as pellet-forming material. Nonetheless, the preparation of acceptable round spheres is highly dependent upon the attainment of an optimal f...
| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
1995
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| Subjects: | |
| Online Access: | http://eprints.usm.my/30616/1/LEE_BEE_CHENG.pdf |
| _version_ | 1797008519135756288 |
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| author | Lee, Bee Cheng |
| author_facet | Lee, Bee Cheng |
| author_sort | Lee, Bee Cheng |
| collection | USM |
| description | Satisfactory spherical pellets were successfully· prepared by the process of
extrusionlspheronization using the excipient microcrystalline cellulose (IvrCC) as
pellet-forming material. Nonetheless, the preparation of acceptable round spheres
is highly dependent upon the attainment of an optimal formulation suited for this
mcthod or proccssillg. The earlier part of the work has revealed that the MCe
pellet system containing the active ingredientdiclofenac sodium generally produced
strongly bonded spheroids which remained intact throughout the dissolution test. It
may thus be postulated that the pellets behaved as an inert matrix system.
Pelet~pelet yang berbentuk sfera telah berjaya disediakan melalui proses
ekstrusi/sferonisasi dengan menggunakan mikrokristalin selulosa sebagai bahan
pembentuk pelet. Walau bagaimanapun, penyediaan sfera yang baik sang at
hc:rr~,HlruJlE kerada remerolehan suatu formulasi optimum yang padan akan proses
tersebut. Kajian awal telah menunjukkan bahawa sistem pelet mikrokristalin
selulosa yang mengandungi ramuan aktif diclofenac sodium, pada amnya
menghasilkan sferoid yang mempunyai ikatan kuat sehingga bentuknya masih kekal
semasa proses pemelarutan. Dengan ini, boleh dikatakan bahawa pelet tersebut
bertindak sebagai sistem matriks lengai. |
| first_indexed | 2024-03-06T14:52:35Z |
| format | Thesis |
| id | usm.eprints-30616 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T14:52:35Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | usm.eprints-306162017-03-22T01:59:56Z http://eprints.usm.my/30616/ Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form Lee, Bee Cheng RS1-441 Pharmacy and materia medica Satisfactory spherical pellets were successfully· prepared by the process of extrusionlspheronization using the excipient microcrystalline cellulose (IvrCC) as pellet-forming material. Nonetheless, the preparation of acceptable round spheres is highly dependent upon the attainment of an optimal formulation suited for this mcthod or proccssillg. The earlier part of the work has revealed that the MCe pellet system containing the active ingredientdiclofenac sodium generally produced strongly bonded spheroids which remained intact throughout the dissolution test. It may thus be postulated that the pellets behaved as an inert matrix system. Pelet~pelet yang berbentuk sfera telah berjaya disediakan melalui proses ekstrusi/sferonisasi dengan menggunakan mikrokristalin selulosa sebagai bahan pembentuk pelet. Walau bagaimanapun, penyediaan sfera yang baik sang at hc:rr~,HlruJlE kerada remerolehan suatu formulasi optimum yang padan akan proses tersebut. Kajian awal telah menunjukkan bahawa sistem pelet mikrokristalin selulosa yang mengandungi ramuan aktif diclofenac sodium, pada amnya menghasilkan sferoid yang mempunyai ikatan kuat sehingga bentuknya masih kekal semasa proses pemelarutan. Dengan ini, boleh dikatakan bahawa pelet tersebut bertindak sebagai sistem matriks lengai. 1995-02 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/30616/1/LEE_BEE_CHENG.pdf Lee, Bee Cheng (1995) Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Lee, Bee Cheng Evaluation Of Spheronized Pellets As Potential Matrix Sustained Release Dosage Form |
| title | Evaluation Of Spheronized Pellets
As Potential Matrix
Sustained Release Dosage Form
|
| title_full | Evaluation Of Spheronized Pellets
As Potential Matrix
Sustained Release Dosage Form
|
| title_fullStr | Evaluation Of Spheronized Pellets
As Potential Matrix
Sustained Release Dosage Form
|
| title_full_unstemmed | Evaluation Of Spheronized Pellets
As Potential Matrix
Sustained Release Dosage Form
|
| title_short | Evaluation Of Spheronized Pellets
As Potential Matrix
Sustained Release Dosage Form
|
| title_sort | evaluation of spheronized pellets as potential matrix sustained release dosage form |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/30616/1/LEE_BEE_CHENG.pdf |
| work_keys_str_mv | AT leebeecheng evaluationofspheronizedpelletsaspotentialmatrixsustainedreleasedosageform |