Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction
Synthesis of polycyclic compounds having spiro nucleus has attracted the attention of synthetic organic chemists because of their highly pronounced biological activities such as antiviral, antimicrobial etc. Therefore, the development of new, rapid, and clean synthetic routes of such compounds is o...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
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2016
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| Online Access: | http://eprints.usm.my/31335/1/Poster_SYAZANA.pdf |
| _version_ | 1825832518704693248 |
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| author | Hasmaruddin, Nurul Syazana Osman , Hasnah Mohamed Yusoff, Nadia Ali, Mohamed Ashraf Ali Hassan, Mohd. Zaheen |
| author_facet | Hasmaruddin, Nurul Syazana Osman , Hasnah Mohamed Yusoff, Nadia Ali, Mohamed Ashraf Ali Hassan, Mohd. Zaheen |
| author_sort | Hasmaruddin, Nurul Syazana |
| collection | USM |
| description | Synthesis of polycyclic compounds having spiro nucleus has attracted the attention of synthetic organic chemists because of their highly pronounced biological activities such as antiviral,
antimicrobial etc. Therefore, the development of new, rapid, and clean synthetic routes of such compounds is of great importance to both medicinal and synthetic chemists. The 1,3-dipolarcycloaddition
reactions are proved to be an efficient method for regio and stereo selective synthesis of structurally complex spiro heterocycles from relatively simple precursors. Molecular docking
provides a consistent and more precise picture of the interaction of biologically active molecules at the receptor level thereby facilitating the designing of novel therapeutic agents. Therefore, potency of
the spiro compounds (4i) was evaluated preliminary through the molecular docking studies. Later substitutions were made in the reference molecule to get the potent compounds. |
| first_indexed | 2024-03-06T14:54:03Z |
| format | Conference or Workshop Item |
| id | usm.eprints-31335 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T14:54:03Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | usm.eprints-313352016-12-23T09:23:19Z http://eprints.usm.my/31335/ Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction Hasmaruddin, Nurul Syazana Osman , Hasnah Mohamed Yusoff, Nadia Ali, Mohamed Ashraf Ali Hassan, Mohd. Zaheen QD1-999 Chemistry QD241-441 Organic chemistry Synthesis of polycyclic compounds having spiro nucleus has attracted the attention of synthetic organic chemists because of their highly pronounced biological activities such as antiviral, antimicrobial etc. Therefore, the development of new, rapid, and clean synthetic routes of such compounds is of great importance to both medicinal and synthetic chemists. The 1,3-dipolarcycloaddition reactions are proved to be an efficient method for regio and stereo selective synthesis of structurally complex spiro heterocycles from relatively simple precursors. Molecular docking provides a consistent and more precise picture of the interaction of biologically active molecules at the receptor level thereby facilitating the designing of novel therapeutic agents. Therefore, potency of the spiro compounds (4i) was evaluated preliminary through the molecular docking studies. Later substitutions were made in the reference molecule to get the potent compounds. 2016-03-15 Conference or Workshop Item PeerReviewed application/pdf en cc_by http://eprints.usm.my/31335/1/Poster_SYAZANA.pdf Hasmaruddin, Nurul Syazana and Osman , Hasnah and Mohamed Yusoff, Nadia and Ali, Mohamed Ashraf Ali and Hassan, Mohd. Zaheen (2016) Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction. In: International Conference on Natural Products 2016 (ICNP 2016) : Meeting The Needs of a Changing World Through Natural Products Biodiscover, 15 - 16th March 2016, Kuala Terengganu, Malaysia . http://icnp2016.umt.edu.my/wp-content/uploads/sites/70/2015/11/ICNP-2016-SCHEDULE.pdf |
| spellingShingle | QD1-999 Chemistry QD241-441 Organic chemistry Hasmaruddin, Nurul Syazana Osman , Hasnah Mohamed Yusoff, Nadia Ali, Mohamed Ashraf Ali Hassan, Mohd. Zaheen Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction |
| title | Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction |
| title_full | Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction |
| title_fullStr | Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction |
| title_full_unstemmed | Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction |
| title_short | Design, Synthesis and Molecular Docking Studies of Some Novel Spiro Derivatives By 1,3-Cycloaddition Reaction |
| title_sort | design synthesis and molecular docking studies of some novel spiro derivatives by 1 3 cycloaddition reaction |
| topic | QD1-999 Chemistry QD241-441 Organic chemistry |
| url | http://eprints.usm.my/31335/1/Poster_SYAZANA.pdf |
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