Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease
Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
2017
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/35859/1/Physiological_research-LPS_induced_memory_impairment_in_rats-a_model_of_AD.pdf |
| _version_ | 1825833358882504704 |
|---|---|
| author | R., Zakaria W. M. H., Wan Yaacob Z., Othman I. , Long A. H. , Ahmad B. , Al-Rahbi |
| author_facet | R., Zakaria W. M. H., Wan Yaacob Z., Othman I. , Long A. H. , Ahmad B. , Al-Rahbi |
| author_sort | R., Zakaria |
| collection | USM |
| description | Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly
worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to
test potential therapeutic agents for disease modification. Among the non-genetically
manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal
model is commonly used. This review paper aims to discuss the possible factors that influence
rats’ response following LPS injection. Factors such as dose of LPS, route of administration,
nature and duration of exposure as well as age and gender of animal used should be taken into
account when designing a study using LPS-induced memory impairment as model for AD. |
| first_indexed | 2024-03-06T15:06:38Z |
| format | Article |
| id | usm.eprints-35859 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:06:38Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | usm.eprints-358592017-07-26T01:06:44Z http://eprints.usm.my/35859/ Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease R., Zakaria W. M. H., Wan Yaacob Z., Othman I. , Long A. H. , Ahmad B. , Al-Rahbi RA0421 Public health. Hygiene. Preventive Medicine Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to discuss the possible factors that influence rats’ response following LPS injection. Factors such as dose of LPS, route of administration, nature and duration of exposure as well as age and gender of animal used should be taken into account when designing a study using LPS-induced memory impairment as model for AD. 2017-04 Article PeerReviewed application/pdf en http://eprints.usm.my/35859/1/Physiological_research-LPS_induced_memory_impairment_in_rats-a_model_of_AD.pdf R., Zakaria and W. M. H., Wan Yaacob and Z., Othman and I. , Long and A. H. , Ahmad and B. , Al-Rahbi (2017) Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease. Physiological research. ISSN 0862-8408 |
| spellingShingle | RA0421 Public health. Hygiene. Preventive Medicine R., Zakaria W. M. H., Wan Yaacob Z., Othman I. , Long A. H. , Ahmad B. , Al-Rahbi Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease |
| title | Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease |
| title_full | Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease |
| title_fullStr | Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease |
| title_full_unstemmed | Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease |
| title_short | Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease |
| title_sort | lipopolysaccharide induced memory impairment in rats a model of alzheimer s disease |
| topic | RA0421 Public health. Hygiene. Preventive Medicine |
| url | http://eprints.usm.my/35859/1/Physiological_research-LPS_induced_memory_impairment_in_rats-a_model_of_AD.pdf |
| work_keys_str_mv | AT rzakaria lipopolysaccharideinducedmemoryimpairmentinratsamodelofalzheimersdisease AT wmhwanyaacob lipopolysaccharideinducedmemoryimpairmentinratsamodelofalzheimersdisease AT zothman lipopolysaccharideinducedmemoryimpairmentinratsamodelofalzheimersdisease AT ilong lipopolysaccharideinducedmemoryimpairmentinratsamodelofalzheimersdisease AT ahahmad lipopolysaccharideinducedmemoryimpairmentinratsamodelofalzheimersdisease AT balrahbi lipopolysaccharideinducedmemoryimpairmentinratsamodelofalzheimersdisease |