In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic cancer cells
Background Pancreatic cancer is one of the most lethal malignant tumors which remains a rampant killer across the globe. Lack of early diagnosis and toxic drugs have failed to improve the survival rate of pancreatic cancer patients, thus new agents that are safe, available and effective are urgen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016
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| Subjects: | |
| Online Access: | http://eprints.usm.my/36984/1/%28In_vitro_antimetastatic_activity%29_1-s2.0-S2090506815000500-main.pdf |
| _version_ | 1825833573896159232 |
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| author | Dahham, Saad Sabbar M. Tabana, Yasser Hassan, Loiy E. Ahmed Ahamed, Mohamed B. Khadeer Majid, Aman Shah Abdul Majid, Amin Malik Shah Abdul |
| author_facet | Dahham, Saad Sabbar M. Tabana, Yasser Hassan, Loiy E. Ahmed Ahamed, Mohamed B. Khadeer Majid, Aman Shah Abdul Majid, Amin Malik Shah Abdul |
| author_sort | Dahham, Saad Sabbar |
| collection | USM |
| description | Background
Pancreatic cancer is one of the most lethal malignant tumors which remains a rampant killer across the globe. Lack of early diagnosis and toxic drugs have failed to improve the survival rate of pancreatic cancer patients, thus new agents that are safe, available and effective are urgently needed.
Objective
The study aimed to investigate the efficacy of Agarwood essential oils in the inhibition of metastasis and induction of apoptosis in the pancreatic cell line (MIA PaCa-2).
Methods
Essential oils of Aquilaria crassna were obtained by hydrodistillation. Chemical characterization was analyzed using FTIR and GCMS. The effects of essential oils against three steps of metastases have been investigated, including cell proliferation, migration and clonogenicity. Hoechst and rhodamine assays confirmed the mechanism of pancreatic cancer cell death.
Results
The results showed that essential oils exhibited potent cytotoxic activity against MIA PaCa-2 cells with an IC50 (11 |
| first_indexed | 2024-03-06T15:09:51Z |
| format | Article |
| id | usm.eprints-36984 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:09:51Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | usm.eprints-369842020-05-04T02:36:57Z http://eprints.usm.my/36984/ In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic cancer cells Dahham, Saad Sabbar M. Tabana, Yasser Hassan, Loiy E. Ahmed Ahamed, Mohamed B. Khadeer Majid, Aman Shah Abdul Majid, Amin Malik Shah Abdul RK1-715 Dentistry RS1-441 Pharmacy and materia medica Background Pancreatic cancer is one of the most lethal malignant tumors which remains a rampant killer across the globe. Lack of early diagnosis and toxic drugs have failed to improve the survival rate of pancreatic cancer patients, thus new agents that are safe, available and effective are urgently needed. Objective The study aimed to investigate the efficacy of Agarwood essential oils in the inhibition of metastasis and induction of apoptosis in the pancreatic cell line (MIA PaCa-2). Methods Essential oils of Aquilaria crassna were obtained by hydrodistillation. Chemical characterization was analyzed using FTIR and GCMS. The effects of essential oils against three steps of metastases have been investigated, including cell proliferation, migration and clonogenicity. Hoechst and rhodamine assays confirmed the mechanism of pancreatic cancer cell death. Results The results showed that essential oils exhibited potent cytotoxic activity against MIA PaCa-2 cells with an IC50 (11 Elsevier 2016-06 Article PeerReviewed application/pdf en http://eprints.usm.my/36984/1/%28In_vitro_antimetastatic_activity%29_1-s2.0-S2090506815000500-main.pdf Dahham, Saad Sabbar and M. Tabana, Yasser and Hassan, Loiy E. Ahmed and Ahamed, Mohamed B. Khadeer and Majid, Aman Shah Abdul and Majid, Amin Malik Shah Abdul (2016) In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic cancer cells. Alexandria Journal of Medicine, 52 (2). pp. 141-150. ISSN 2090-5068 https://doi.org/10.1016/j.ajme.2015.07.001 |
| spellingShingle | RK1-715 Dentistry RS1-441 Pharmacy and materia medica Dahham, Saad Sabbar M. Tabana, Yasser Hassan, Loiy E. Ahmed Ahamed, Mohamed B. Khadeer Majid, Aman Shah Abdul Majid, Amin Malik Shah Abdul In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic cancer cells |
| title | In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic
cancer cells |
| title_full | In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic
cancer cells |
| title_fullStr | In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic
cancer cells |
| title_full_unstemmed | In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic
cancer cells |
| title_short | In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic
cancer cells |
| title_sort | in vitro antimetastatic activity of agarwood aquilaria crassna essential oils against pancreatic cancer cells |
| topic | RK1-715 Dentistry RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/36984/1/%28In_vitro_antimetastatic_activity%29_1-s2.0-S2090506815000500-main.pdf |
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