Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs
A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects. These drugs change the mental state and/or the behavioral performance of an individual and can be instrumentalized for various purpo...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media
2017
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| Subjects: | |
| Online Access: | http://eprints.usm.my/37094/1/%28Novel_Psychoactive_Substances%29_fpsyt-08-00152.pdf |
| _version_ | 1825833594182959104 |
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| author | Hassan, Zurina Oliver G., Bosch Singh, Darshan Narayanan, Suresh Kasinather, B. Vicknasingam Erich, Seifritz Johannes, Kornhuber Boris B. , Quednow Christian P. , Müller |
| author_facet | Hassan, Zurina Oliver G., Bosch Singh, Darshan Narayanan, Suresh Kasinather, B. Vicknasingam Erich, Seifritz Johannes, Kornhuber Boris B. , Quednow Christian P. , Müller |
| author_sort | Hassan, Zurina |
| collection | USM |
| description | A feature of human culture is that we can learn to consume chemical compounds,
derived from natural plants or synthetic fabrication, for their psychoactive effects. These
drugs change the mental state and/or the behavioral performance of an individual and
can be instrumentalized for various purposes. After the emergence of a novel psychoactive
substance (NPS) and a period of experimental consumption, personal and medical
benefits and harm potential of the NPS can be estimated on evidence base. This may
lead to a legal classification of the NPS, which may range from limited medical use,
controlled availability up to a complete ban of the drug form publically accepted use.
With these measures, however, a drug does not disappear, but frequently continues to
be used, which eventually allows an even better estimate of the drug 19s properties. Thus,
only in rare cases, there is a final verdict that is no more questioned. Instead, the view on
a drug can change from tolerable to harmful but may also involve the new establishment
of a desired medical application to a previously harmful drug. Here, we provide a summary
review on a number of NPS for which the neuropharmacological evaluation has
made important progress in recent years. They include mitragynine ( 1CKratom 1D), synthetic
cannabinoids (e.g., 1CSpice 1D), dimethyltryptamine and novel serotonergic hallucinogens,
the cathinones mephedrone and methylone, ketamine and novel dissociative drugs,
;3-hydroxybutyrate, ;3-butyrolactone, and 1,4-butanediol. This review shows not only
emerging harm potentials but also some potential medical applications. |
| first_indexed | 2024-03-06T15:10:10Z |
| format | Article |
| id | usm.eprints-37094 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:10:10Z |
| publishDate | 2017 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | usm.eprints-370942017-10-13T01:00:41Z http://eprints.usm.my/37094/ Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs Hassan, Zurina Oliver G., Bosch Singh, Darshan Narayanan, Suresh Kasinather, B. Vicknasingam Erich, Seifritz Johannes, Kornhuber Boris B. , Quednow Christian P. , Müller H1-99 Social sciences (General) RM300-666 Drugs and their actions A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects. These drugs change the mental state and/or the behavioral performance of an individual and can be instrumentalized for various purposes. After the emergence of a novel psychoactive substance (NPS) and a period of experimental consumption, personal and medical benefits and harm potential of the NPS can be estimated on evidence base. This may lead to a legal classification of the NPS, which may range from limited medical use, controlled availability up to a complete ban of the drug form publically accepted use. With these measures, however, a drug does not disappear, but frequently continues to be used, which eventually allows an even better estimate of the drug 19s properties. Thus, only in rare cases, there is a final verdict that is no more questioned. Instead, the view on a drug can change from tolerable to harmful but may also involve the new establishment of a desired medical application to a previously harmful drug. Here, we provide a summary review on a number of NPS for which the neuropharmacological evaluation has made important progress in recent years. They include mitragynine ( 1CKratom 1D), synthetic cannabinoids (e.g., 1CSpice 1D), dimethyltryptamine and novel serotonergic hallucinogens, the cathinones mephedrone and methylone, ketamine and novel dissociative drugs, ;3-hydroxybutyrate, ;3-butyrolactone, and 1,4-butanediol. This review shows not only emerging harm potentials but also some potential medical applications. Frontiers Media 2017-08 Article PeerReviewed application/pdf en http://eprints.usm.my/37094/1/%28Novel_Psychoactive_Substances%29_fpsyt-08-00152.pdf Hassan, Zurina and Oliver G., Bosch and Singh, Darshan and Narayanan, Suresh and Kasinather, B. Vicknasingam and Erich, Seifritz and Johannes, Kornhuber and Boris B. , Quednow and Christian P. , Müller (2017) Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs. Frontiers in Psychiatry, 8 (152). pp. 1-21. ISSN 1664-0640 https://doi.org/10.3389/fpsyt.2017.00152 |
| spellingShingle | H1-99 Social sciences (General) RM300-666 Drugs and their actions Hassan, Zurina Oliver G., Bosch Singh, Darshan Narayanan, Suresh Kasinather, B. Vicknasingam Erich, Seifritz Johannes, Kornhuber Boris B. , Quednow Christian P. , Müller Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs |
| title | Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs |
| title_full | Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs |
| title_fullStr | Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs |
| title_full_unstemmed | Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs |
| title_short | Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs |
| title_sort | novel psychoactive substances 14recent progress on neuropharmacological mechanisms of action for selected drugs |
| topic | H1-99 Social sciences (General) RM300-666 Drugs and their actions |
| url | http://eprints.usm.my/37094/1/%28Novel_Psychoactive_Substances%29_fpsyt-08-00152.pdf |
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