Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis
Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis (Mtb). About one-third of the world’s population is latently infected with TB and 5–15% of them will develop active TB in their lifetime. It is estimated that each case of active TB may cause 10–20 new infections. Host...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2017
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| Online Access: | http://eprints.usm.my/37197/1/%28Role_of_Interferons_in_the%29_5212910.pdf |
| _version_ | 1825833613632995328 |
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| author | Kai, Ling Chin Zulkipli Anis, Fadhilah Sarmiento, Maria E. Norazmi, Mohd Nor Acosta, Armando |
| author_facet | Kai, Ling Chin Zulkipli Anis, Fadhilah Sarmiento, Maria E. Norazmi, Mohd Nor Acosta, Armando |
| author_sort | Kai, Ling Chin |
| collection | USM |
| description | Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis (Mtb). About one-third of the world’s population
is latently infected with TB and 5–15% of them will develop active TB in their lifetime. It is estimated that each case of active TB may
cause 10–20 new infections. Host immune response to Mtb is influenced by interferon- (IFN-) signaling pathways, particularly by
type I and type II interferons (IFNs). The latter that consists of IFN-γ has been associated with the promotion of Th1 immune
response which is associated with protection against TB. Although this aspect remains controversial at present due to the lack of
established correlates of protection, currently, there are different prophylactic, diagnostic, and immunotherapeutic approaches in
which IFNs play an important role. This review summarizes the main aspects related with the biology of IFNs, mainly
associated with TB, as well as presents the main applications of these cytokines related to prophylaxis, diagnosis, and
immunotherapy of TB. |
| first_indexed | 2024-03-06T15:10:27Z |
| format | Article |
| id | usm.eprints-37197 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:10:27Z |
| publishDate | 2017 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | usm.eprints-371972017-10-19T01:33:38Z http://eprints.usm.my/37197/ Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis Kai, Ling Chin Zulkipli Anis, Fadhilah Sarmiento, Maria E. Norazmi, Mohd Nor Acosta, Armando R5-130.5 General works Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis (Mtb). About one-third of the world’s population is latently infected with TB and 5–15% of them will develop active TB in their lifetime. It is estimated that each case of active TB may cause 10–20 new infections. Host immune response to Mtb is influenced by interferon- (IFN-) signaling pathways, particularly by type I and type II interferons (IFNs). The latter that consists of IFN-γ has been associated with the promotion of Th1 immune response which is associated with protection against TB. Although this aspect remains controversial at present due to the lack of established correlates of protection, currently, there are different prophylactic, diagnostic, and immunotherapeutic approaches in which IFNs play an important role. This review summarizes the main aspects related with the biology of IFNs, mainly associated with TB, as well as presents the main applications of these cytokines related to prophylaxis, diagnosis, and immunotherapy of TB. Hindawi Publishing Corporation 2017 Article PeerReviewed application/pdf en http://eprints.usm.my/37197/1/%28Role_of_Interferons_in_the%29_5212910.pdf Kai, Ling Chin and Zulkipli Anis, Fadhilah and Sarmiento, Maria E. and Norazmi, Mohd Nor and Acosta, Armando (2017) Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis. Journal of Immunology Research, 2017 (521291). pp. 1-10. ISSN 2314-8861 https://doi.org/10.1155/2017/5212910 |
| spellingShingle | R5-130.5 General works Kai, Ling Chin Zulkipli Anis, Fadhilah Sarmiento, Maria E. Norazmi, Mohd Nor Acosta, Armando Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis |
| title | Role of Interferons in the Development of Diagnostics,
Vaccines, and Therapy for Tuberculosis |
| title_full | Role of Interferons in the Development of Diagnostics,
Vaccines, and Therapy for Tuberculosis |
| title_fullStr | Role of Interferons in the Development of Diagnostics,
Vaccines, and Therapy for Tuberculosis |
| title_full_unstemmed | Role of Interferons in the Development of Diagnostics,
Vaccines, and Therapy for Tuberculosis |
| title_short | Role of Interferons in the Development of Diagnostics,
Vaccines, and Therapy for Tuberculosis |
| title_sort | role of interferons in the development of diagnostics vaccines and therapy for tuberculosis |
| topic | R5-130.5 General works |
| url | http://eprints.usm.my/37197/1/%28Role_of_Interferons_in_the%29_5212910.pdf |
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