The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats
Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized extract on the oestrous cycle, levels of reproductive hormones and histology of the ovaries of Sprague-Dawley rats. Methods: Female rats were orally treated with E. longifolia standardized extract at the dose...
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| Format: | Article |
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Elsevier
2017
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| _version_ | 1825833625916014592 |
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| author | Abdul Rahman, Suzanah Ahmad, Nur Amalina Abdul Samat, Nadia Hanis Zahri, Syazana Abdullah, Afif Raihan Chan, Kit Lam |
| author_facet | Abdul Rahman, Suzanah Ahmad, Nur Amalina Abdul Samat, Nadia Hanis Zahri, Syazana Abdullah, Afif Raihan Chan, Kit Lam |
| author_sort | Abdul Rahman, Suzanah |
| collection | USM |
| description | Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized
extract on the oestrous cycle, levels of reproductive hormones and histology of the
ovaries of Sprague-Dawley rats.
Methods: Female rats were orally treated with E. longifolia standardized extract at the
dose levels of 2.5, 5.0, 10.0, 25.0, 50.0 and 100.0 mg/kg of body weight over 5 days.
Vaginal smears were monitored daily within the duration and after withdrawal of the
treatment before being sacrificed. The body weights of the females were recorded before
and after the 5 days treatment. At the end of the experiments, blood samples were
collected for determination of testosterone, oestradiol and progesterone levels. Ovaries
were removed, weighed and examined for histomorphological changes.
Results: The administration of E. longifolia standardized extract did not significantly
alter the oestrous cycle of the rats during the 5 days treatment and after withdrawal of the
treatments. This was supported by normal testosterone, oestradiol and progesterone levels
as well as normal morphology of the ovaries.
Conclusions: The data obtained showed that E. longifolia standardized extract did not
exhibit any toxic effect on reproductive activities of female rats suggesting potential use
in the management of infertility. |
| first_indexed | 2024-03-06T15:10:38Z |
| format | Article |
| id | usm.eprints-37262 |
| institution | Universiti Sains Malaysia |
| last_indexed | 2024-03-06T15:10:38Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | usm.eprints-372622017-10-30T04:11:40Z http://eprints.usm.my/37262/ The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats Abdul Rahman, Suzanah Ahmad, Nur Amalina Abdul Samat, Nadia Hanis Zahri, Syazana Abdullah, Afif Raihan Chan, Kit Lam RS1-441 Pharmacy and materia medica Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized extract on the oestrous cycle, levels of reproductive hormones and histology of the ovaries of Sprague-Dawley rats. Methods: Female rats were orally treated with E. longifolia standardized extract at the dose levels of 2.5, 5.0, 10.0, 25.0, 50.0 and 100.0 mg/kg of body weight over 5 days. Vaginal smears were monitored daily within the duration and after withdrawal of the treatment before being sacrificed. The body weights of the females were recorded before and after the 5 days treatment. At the end of the experiments, blood samples were collected for determination of testosterone, oestradiol and progesterone levels. Ovaries were removed, weighed and examined for histomorphological changes. Results: The administration of E. longifolia standardized extract did not significantly alter the oestrous cycle of the rats during the 5 days treatment and after withdrawal of the treatments. This was supported by normal testosterone, oestradiol and progesterone levels as well as normal morphology of the ovaries. Conclusions: The data obtained showed that E. longifolia standardized extract did not exhibit any toxic effect on reproductive activities of female rats suggesting potential use in the management of infertility. Elsevier 2017-01 Article PeerReviewed Abdul Rahman, Suzanah and Ahmad, Nur Amalina and Abdul Samat, Nadia Hanis and Zahri, Syazana and Abdullah, Afif Raihan and Chan, Kit Lam (2017) The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats. Asian Pacific Journal of Tropical Biomedicine, 7 (1). pp. 27-31. ISSN 2221-1691 http://dx.doi.org/10.1016/j.apjtb.2016.07.016 |
| spellingShingle | RS1-441 Pharmacy and materia medica Abdul Rahman, Suzanah Ahmad, Nur Amalina Abdul Samat, Nadia Hanis Zahri, Syazana Abdullah, Afif Raihan Chan, Kit Lam The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
| title | The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
| title_full | The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
| title_fullStr | The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
| title_full_unstemmed | The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
| title_short | The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats |
| title_sort | potential of standardized quassinoid rich extract of eurycoma longifolia in the regulation of the oestrous cycle of rats |
| topic | RS1-441 Pharmacy and materia medica |
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