Effects of different mycotoxins on humans, cell genome and their involvement in cancer (Review)
The chemical nature of most of the mycotoxins makes them highly liposoluble compounds that can be absorbed from the site of exposure such as from the gastrointestinal and respiratory tract to the blood stream where it can be dissimilated throughout the body and reach different organs such as th...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Spandidos Publications
2017
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/37321/1/or_37_3_1321_PDF1.pdf |
| _version_ | 1797009808121921536 |
|---|---|
| author | Ahmed Adam, Mowaffaq Adam Tabana, Yasser M. Musa , Khirun Sandai, Doblin |
| author_facet | Ahmed Adam, Mowaffaq Adam Tabana, Yasser M. Musa , Khirun Sandai, Doblin |
| author_sort | Ahmed Adam, Mowaffaq Adam |
| collection | USM |
| description | The chemical nature of most of the mycotoxins
makes them highly liposoluble compounds that can be
absorbed from the site of exposure such as from the gastrointestinal
and respiratory tract to the blood stream where it
can be dissimilated throughout the body and reach different
organs such as the liver and kidneys. Mycotoxins have a strong
tendency and ability to penetrate the human and animal cells
and reach the cellular genome where it causes a major mutagenic
change in the nucleotide sequence which leads to strong
and permanent defects in the genome. This defect will eventually
be transcribed, translated and lead to the development
of cancer. In this review, the chemical and physical nature of
mycotoxins, the action of mycotoxins on the cellular genome
and its effect on humans, mycotoxins and their carcinogenicity
and mycotoxins research gaps are discussed, and new research
areas are suggested. The research review posed various questions.
What are the different mycotoxins that can cause cancer,
what is the role of mycotoxins in causing cancer and what
types of cancers can be caused by mycotoxins? These questions
have been selected due to the significant increase in the
mycotoxin contamination and the cancer incidence rate in the
contemporary world. By revealing and understanding the role
of mycotoxins in developing cancer, measures to reduce the
risks and incidents of cancer could be taken. |
| first_indexed | 2024-03-06T15:10:48Z |
| format | Article |
| id | usm.eprints-37321 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:10:48Z |
| publishDate | 2017 |
| publisher | Spandidos Publications |
| record_format | dspace |
| spelling | usm.eprints-373212017-11-02T08:44:25Z http://eprints.usm.my/37321/ Effects of different mycotoxins on humans, cell genome and their involvement in cancer (Review) Ahmed Adam, Mowaffaq Adam Tabana, Yasser M. Musa , Khirun Sandai, Doblin QH426-470 Genetics R5-920 Medicine (General) The chemical nature of most of the mycotoxins makes them highly liposoluble compounds that can be absorbed from the site of exposure such as from the gastrointestinal and respiratory tract to the blood stream where it can be dissimilated throughout the body and reach different organs such as the liver and kidneys. Mycotoxins have a strong tendency and ability to penetrate the human and animal cells and reach the cellular genome where it causes a major mutagenic change in the nucleotide sequence which leads to strong and permanent defects in the genome. This defect will eventually be transcribed, translated and lead to the development of cancer. In this review, the chemical and physical nature of mycotoxins, the action of mycotoxins on the cellular genome and its effect on humans, mycotoxins and their carcinogenicity and mycotoxins research gaps are discussed, and new research areas are suggested. The research review posed various questions. What are the different mycotoxins that can cause cancer, what is the role of mycotoxins in causing cancer and what types of cancers can be caused by mycotoxins? These questions have been selected due to the significant increase in the mycotoxin contamination and the cancer incidence rate in the contemporary world. By revealing and understanding the role of mycotoxins in developing cancer, measures to reduce the risks and incidents of cancer could be taken. Spandidos Publications 2017-02 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/37321/1/or_37_3_1321_PDF1.pdf Ahmed Adam, Mowaffaq Adam and Tabana, Yasser M. and Musa , Khirun and Sandai, Doblin (2017) Effects of different mycotoxins on humans, cell genome and their involvement in cancer (Review). Oncology Reports, 37 (3). pp. 1321-1336. ISSN 1021-335X https://www.spandidos-publications.com/or/37/3/1321 |
| spellingShingle | QH426-470 Genetics R5-920 Medicine (General) Ahmed Adam, Mowaffaq Adam Tabana, Yasser M. Musa , Khirun Sandai, Doblin Effects of different mycotoxins on humans, cell genome and their involvement in cancer (Review) |
| title | Effects of different mycotoxins on humans, cell genome
and their involvement in cancer (Review) |
| title_full | Effects of different mycotoxins on humans, cell genome
and their involvement in cancer (Review) |
| title_fullStr | Effects of different mycotoxins on humans, cell genome
and their involvement in cancer (Review) |
| title_full_unstemmed | Effects of different mycotoxins on humans, cell genome
and their involvement in cancer (Review) |
| title_short | Effects of different mycotoxins on humans, cell genome
and their involvement in cancer (Review) |
| title_sort | effects of different mycotoxins on humans cell genome and their involvement in cancer review |
| topic | QH426-470 Genetics R5-920 Medicine (General) |
| url | http://eprints.usm.my/37321/1/or_37_3_1321_PDF1.pdf |
| work_keys_str_mv | AT ahmedadammowaffaqadam effectsofdifferentmycotoxinsonhumanscellgenomeandtheirinvolvementincancerreview AT tabanayasserm effectsofdifferentmycotoxinsonhumanscellgenomeandtheirinvolvementincancerreview AT musakhirun effectsofdifferentmycotoxinsonhumanscellgenomeandtheirinvolvementincancerreview AT sandaidoblin effectsofdifferentmycotoxinsonhumanscellgenomeandtheirinvolvementincancerreview |