CD19 Deficient B Cell Abnormality and Selective IgM Deficiency in a Malay Child. A Case Report.
Cases of CD 19 deficiency from South East Asia has rarely been reported. A, 1l yr Malay boy was referred with recurrent infections with 2 episodes of'chickenpox at age 2 years. He had repeated episodes of pneumoniae and bronchiectasis by age 6 years. Physical examination revealed gross clu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Verlag
2012
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| Subjects: | |
| Online Access: | http://eprints.usm.my/37398/1/CD19Deficient.pdf |
| _version_ | 1797009822493704192 |
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| author | Nohl, L.M. Rus Anidah, R.A. Thiyagara, N. Abd Hamid, Intan Juliana Hashim, I. Latif, A.H. |
| author_facet | Nohl, L.M. Rus Anidah, R.A. Thiyagara, N. Abd Hamid, Intan Juliana Hashim, I. Latif, A.H. |
| author_sort | Nohl, L.M. |
| collection | USM |
| description | Cases of CD 19 deficiency from South
East Asia has rarely been reported. A, 1l yr Malay boy
was referred with recurrent infections with 2 episodes
of'chickenpox at age 2 years. He had repeated episodes
of pneumoniae and bronchiectasis by age 6 years.
Physical examination revealed gross clubbing with
crepitations at both lung bases. IV lg administration
was instituted with clinical improvementlaboratory
data: Serum Ig (g/l )IgG 8.37[n 4.95- 16.56 ], IgA
0.92[n 0.30-2.35 7, lgM 0.21 [0.32-1.4}]Lymphocyte
subset (age 1l) CD19 Q o
, CD20 11.26% (12-22)CD3
83.64% (n 66-76) ,CD4 36.25 ( 33-41),CD8 41.55 (27-
35), CDl6+56 I1.6 %. (9-16),Specific antibody
response to polysaccharide antigen was impaired ;
whileNBT , lymphocyte proliferation to (PHA ) were
normal, Btk protein 18% (control 87.8 %). Our finding
conforms with a diagnosis of CD19 deficiency with
selective IgM deficiency and partial defective Btk
protein expression. |
| first_indexed | 2024-03-06T15:11:01Z |
| format | Article |
| id | usm.eprints-37398 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:11:01Z |
| publishDate | 2012 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | usm.eprints-373982017-11-14T09:08:58Z http://eprints.usm.my/37398/ CD19 Deficient B Cell Abnormality and Selective IgM Deficiency in a Malay Child. A Case Report. Nohl, L.M. Rus Anidah, R.A. Thiyagara, N. Abd Hamid, Intan Juliana Hashim, I. Latif, A.H. RC31-1245 Internal medicine Cases of CD 19 deficiency from South East Asia has rarely been reported. A, 1l yr Malay boy was referred with recurrent infections with 2 episodes of'chickenpox at age 2 years. He had repeated episodes of pneumoniae and bronchiectasis by age 6 years. Physical examination revealed gross clubbing with crepitations at both lung bases. IV lg administration was instituted with clinical improvementlaboratory data: Serum Ig (g/l )IgG 8.37[n 4.95- 16.56 ], IgA 0.92[n 0.30-2.35 7, lgM 0.21 [0.32-1.4}]Lymphocyte subset (age 1l) CD19 Q o , CD20 11.26% (12-22)CD3 83.64% (n 66-76) ,CD4 36.25 ( 33-41),CD8 41.55 (27- 35), CDl6+56 I1.6 %. (9-16),Specific antibody response to polysaccharide antigen was impaired ; whileNBT , lymphocyte proliferation to (PHA ) were normal, Btk protein 18% (control 87.8 %). Our finding conforms with a diagnosis of CD19 deficiency with selective IgM deficiency and partial defective Btk protein expression. Springer Verlag 2012 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/37398/1/CD19Deficient.pdf Nohl, L.M. and Rus Anidah, R.A. and Thiyagara, N. and Abd Hamid, Intan Juliana and Hashim, I. and Latif, A.H. (2012) CD19 Deficient B Cell Abnormality and Selective IgM Deficiency in a Malay Child. A Case Report. Journal of Clinical Immunology, 32 (1 Sup.). p. 289. ISSN 0271-9142 |
| spellingShingle | RC31-1245 Internal medicine Nohl, L.M. Rus Anidah, R.A. Thiyagara, N. Abd Hamid, Intan Juliana Hashim, I. Latif, A.H. CD19 Deficient B Cell Abnormality and Selective IgM Deficiency in a Malay Child. A Case Report. |
| title | CD19 Deficient B Cell Abnormality and Selective IgM Deficiency in a Malay Child. A Case Report. |
| title_full | CD19 Deficient B Cell Abnormality and Selective IgM Deficiency in a Malay Child. A Case Report. |
| title_fullStr | CD19 Deficient B Cell Abnormality and Selective IgM Deficiency in a Malay Child. A Case Report. |
| title_full_unstemmed | CD19 Deficient B Cell Abnormality and Selective IgM Deficiency in a Malay Child. A Case Report. |
| title_short | CD19 Deficient B Cell Abnormality and Selective IgM Deficiency in a Malay Child. A Case Report. |
| title_sort | cd19 deficient b cell abnormality and selective igm deficiency in a malay child a case report |
| topic | RC31-1245 Internal medicine |
| url | http://eprints.usm.my/37398/1/CD19Deficient.pdf |
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