| Summary: | Recently, we showed that the antiproliferative effect of ZER-NLC on Jurkat cells is through the apoptotic intrinsic pathway via activation of caspase-3 and -9, release of
cytochrome c (cyt-c) from mitochondria into cytosol, and subsequent cleavage of
polyADP-ribose polymerase (PARP). However, there has been no available
information of ZER-NLC affects murine breast cancer cells in vivo. Thus, In this
study, in vivo effects of ZER-NLC on murine breast cancer 4T1 cells were
investigated. Outcomes of histopathology, immunohistochemistry and TUNEL assays
of BALB/c mice bearing breast cancer revealed that the number of cancer cells were
significantly decreased in mammary gland tissues after four weeks of oral
administration of various doses of ZER-NLC.
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