A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 μM against ace...

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Main Authors: I. Almansour, Abdulrahman, Kumar, Raju Suresh, Arumugam, Natarajan, Basiri, Alireza, Kia, Yalda, Ali, Mohamed Ashraf, Farooq, Mehvish, Murugaiyah, Vikneswaran
Format: Article
Language:English
Published: MDPI 2015
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Online Access:http://eprints.usm.my/38014/1/A_Facile_Ionic_Liquid_Promoted_Synthesis%2C_Cholinesterase_Inhibitory.pdf
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author I. Almansour, Abdulrahman
Kumar, Raju Suresh
Arumugam, Natarajan
Basiri, Alireza
Kia, Yalda
Ali, Mohamed Ashraf
Farooq, Mehvish
Murugaiyah, Vikneswaran
author_facet I. Almansour, Abdulrahman
Kumar, Raju Suresh
Arumugam, Natarajan
Basiri, Alireza
Kia, Yalda
Ali, Mohamed Ashraf
Farooq, Mehvish
Murugaiyah, Vikneswaran
author_sort I. Almansour, Abdulrahman
collection USM
description A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 μM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor.
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spelling usm.eprints-380142017-12-20T04:34:10Z http://eprints.usm.my/38014/ A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines I. Almansour, Abdulrahman Kumar, Raju Suresh Arumugam, Natarajan Basiri, Alireza Kia, Yalda Ali, Mohamed Ashraf Farooq, Mehvish Murugaiyah, Vikneswaran QD1-999 Chemistry R735-854 Medical education. Medical schools. Research RS1-441 Pharmacy and materia medica A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 μM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor. MDPI 2015-01 Article PeerReviewed application/pdf en http://eprints.usm.my/38014/1/A_Facile_Ionic_Liquid_Promoted_Synthesis%2C_Cholinesterase_Inhibitory.pdf I. Almansour, Abdulrahman and Kumar, Raju Suresh and Arumugam, Natarajan and Basiri, Alireza and Kia, Yalda and Ali, Mohamed Ashraf and Farooq, Mehvish and Murugaiyah, Vikneswaran (2015) A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines. Molecules, 20 (2). pp. 2296-2309. ISSN 1420-3049 https://doi.org/10.3390/molecules20022296
spellingShingle QD1-999 Chemistry
R735-854 Medical education. Medical schools. Research
RS1-441 Pharmacy and materia medica
I. Almansour, Abdulrahman
Kumar, Raju Suresh
Arumugam, Natarajan
Basiri, Alireza
Kia, Yalda
Ali, Mohamed Ashraf
Farooq, Mehvish
Murugaiyah, Vikneswaran
A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title_full A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title_fullStr A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title_full_unstemmed A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title_short A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
title_sort facile ionic liquid promoted synthesis cholinesterase inhibitory activity and molecular modeling study of novel highly functionalized spiropyrrolidines
topic QD1-999 Chemistry
R735-854 Medical education. Medical schools. Research
RS1-441 Pharmacy and materia medica
url http://eprints.usm.my/38014/1/A_Facile_Ionic_Liquid_Promoted_Synthesis%2C_Cholinesterase_Inhibitory.pdf
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