Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats
Syzygium polyanthum (S. polyanthum), a plant belonging to Myrtaceae, is widely used in Indonesian and Malaysian cuisines. Diabetic patients in Indonesia also commonly use it as a traditional medicine. Hence, this study was conducted to investigate the antihyperglycemic effect of the methanol extr...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI
2015
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/38331/1/Antihyperglycemic_Effect_of_Methanol_Extract_of_Syzygium_polyanthum.pdf |
| _version_ | 1825833831813349376 |
|---|---|
| author | Widyawati, Tri Yusoff, Nor Adlin Asmawi, Mohd Zaini Ahmad, Mariam |
| author_facet | Widyawati, Tri Yusoff, Nor Adlin Asmawi, Mohd Zaini Ahmad, Mariam |
| author_sort | Widyawati, Tri |
| collection | USM |
| description | Syzygium polyanthum (S. polyanthum), a plant belonging to Myrtaceae, is widely
used in Indonesian and Malaysian cuisines. Diabetic patients in Indonesia also commonly
use it as a traditional medicine. Hence, this study was conducted to investigate the
antihyperglycemic effect of the methanol extract (ME) of S. polyanthum leaf and its possible
mechanisms of action. To test for hypoglycemic activity, ME was administered orally to
normal male Sprague Dawley rats after a 12-h fast. To further test for antihyperglycemic
activity, the same treatment was administered to glucose-loaded (intraperitoneal glucose
tolerance test, IPGTT) and streptozotocin (STZ)-induced diabetic rats, respectively.
Hypoglycemic test in normal rats did not show significant reduction in blood glucose
levels (BGLs) by the extract. Furthermore, IPGTT conducted on glucose-loaded normal
rats also did not show significant reduction of BGLs. However, repeated administration of
metformin and three doses of ME (250, 500 and 1000 mg/kg) for six days caused significant
reduction of fasting BGLs in STZ-induced diabetic rats. The possible mechanisms of
action of S. polyanthum antihyperglycemic activity were assessed by measurement of
intestinal glucose absorption and glucose uptake by isolated rat abdominal muscle. |
| first_indexed | 2024-03-06T15:13:42Z |
| format | Article |
| id | usm.eprints-38331 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:13:42Z |
| publishDate | 2015 |
| publisher | MDPI |
| record_format | dspace |
| spelling | usm.eprints-383312018-01-10T08:06:43Z http://eprints.usm.my/38331/ Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats Widyawati, Tri Yusoff, Nor Adlin Asmawi, Mohd Zaini Ahmad, Mariam RK1-715 Dentistry RS1-441 Pharmacy and materia medica Syzygium polyanthum (S. polyanthum), a plant belonging to Myrtaceae, is widely used in Indonesian and Malaysian cuisines. Diabetic patients in Indonesia also commonly use it as a traditional medicine. Hence, this study was conducted to investigate the antihyperglycemic effect of the methanol extract (ME) of S. polyanthum leaf and its possible mechanisms of action. To test for hypoglycemic activity, ME was administered orally to normal male Sprague Dawley rats after a 12-h fast. To further test for antihyperglycemic activity, the same treatment was administered to glucose-loaded (intraperitoneal glucose tolerance test, IPGTT) and streptozotocin (STZ)-induced diabetic rats, respectively. Hypoglycemic test in normal rats did not show significant reduction in blood glucose levels (BGLs) by the extract. Furthermore, IPGTT conducted on glucose-loaded normal rats also did not show significant reduction of BGLs. However, repeated administration of metformin and three doses of ME (250, 500 and 1000 mg/kg) for six days caused significant reduction of fasting BGLs in STZ-induced diabetic rats. The possible mechanisms of action of S. polyanthum antihyperglycemic activity were assessed by measurement of intestinal glucose absorption and glucose uptake by isolated rat abdominal muscle. MDPI 2015 Article PeerReviewed application/pdf en http://eprints.usm.my/38331/1/Antihyperglycemic_Effect_of_Methanol_Extract_of_Syzygium_polyanthum.pdf Widyawati, Tri and Yusoff, Nor Adlin and Asmawi, Mohd Zaini and Ahmad, Mariam (2015) Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats. Nutrients, 7 (9). pp. 7764-7780. ISSN 2072-6643 https://www.ncbi.nlm.nih.gov/pubmed/26389944 |
| spellingShingle | RK1-715 Dentistry RS1-441 Pharmacy and materia medica Widyawati, Tri Yusoff, Nor Adlin Asmawi, Mohd Zaini Ahmad, Mariam Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats |
| title | Antihyperglycemic Effect of Methanol Extract of Syzygium
polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats |
| title_full | Antihyperglycemic Effect of Methanol Extract of Syzygium
polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats |
| title_fullStr | Antihyperglycemic Effect of Methanol Extract of Syzygium
polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats |
| title_full_unstemmed | Antihyperglycemic Effect of Methanol Extract of Syzygium
polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats |
| title_short | Antihyperglycemic Effect of Methanol Extract of Syzygium
polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats |
| title_sort | antihyperglycemic effect of methanol extract of syzygium polyanthum wight leaf in streptozotocin induced diabetic rats |
| topic | RK1-715 Dentistry RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/38331/1/Antihyperglycemic_Effect_of_Methanol_Extract_of_Syzygium_polyanthum.pdf |
| work_keys_str_mv | AT widyawatitri antihyperglycemiceffectofmethanolextractofsyzygiumpolyanthumwightleafinstreptozotocininduceddiabeticrats AT yusoffnoradlin antihyperglycemiceffectofmethanolextractofsyzygiumpolyanthumwightleafinstreptozotocininduceddiabeticrats AT asmawimohdzaini antihyperglycemiceffectofmethanolextractofsyzygiumpolyanthumwightleafinstreptozotocininduceddiabeticrats AT ahmadmariam antihyperglycemiceffectofmethanolextractofsyzygiumpolyanthumwightleafinstreptozotocininduceddiabeticrats |