Anti-inflammatory, anthropometric and lipomodulatory effects Dyglomera® (aqueous extract of Dichrostachys glomerata) in obese patients with metabolic syndrome
Background: Increased visceral fat, dyslipidemia and increased markers of inflammation and coagulation are cardiovascular risk factors commonly encountered in obese people with metabolic syndrome. Previous studies have shown that ground Dichrostachys glomerata (DG), a spice used in Western Cameroon,...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Food Science Publisher
2013
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/38333/1/Anti-inflammatory%2C_anthropometric_and_lipomodulatory_effects.pdf |
| _version_ | 1797010011279327232 |
|---|---|
| author | Dieudonne, Kuate Blanche C., Etoundi Judith L., Ngondi Wan Muda, Wan Abdul Manan Julius E., Oben |
| author_facet | Dieudonne, Kuate Blanche C., Etoundi Judith L., Ngondi Wan Muda, Wan Abdul Manan Julius E., Oben |
| author_sort | Dieudonne, Kuate |
| collection | USM |
| description | Background: Increased visceral fat, dyslipidemia and increased markers of inflammation and coagulation are cardiovascular risk factors commonly encountered in obese people with metabolic syndrome. Previous studies have shown that ground Dichrostachys glomerata (DG), a spice used in Western Cameroon, can have beneficial effects on inflammation and various other cardiovascular disease risk factors. The purpose of the present study was to evaluate the effects of Dyglomera®, an aqueous extract of DG (standardized to NLT 10% polyphenols) on certain anthropometric, biochemical (including pro-inflammatory and pro-thrombotic states) and hemodynamic parameters in obese patients with metabolic syndrome.
Methods: The study was an 8-week randomized, double-blind, placebo-controlled trial involving 116 males and 202 females aged between 24 and 58 years. Participants were randomly divided into two groups: treatment and placebo. Capsules containing the active treatment (200 mg Dyglomera®) or placebo (200 mg maize powder) were administered 30–60 minutes before lunch and dinner throughout the study period. Various biochemical (namely, blood glucose, lipid profile, pro-inflammatory and pro-thrombotic markers), anthropometric and hemodynamic parameters were measured at baseline and after 4 and 8 weeks of treatment.Results: At the end of the study, the Dyglomera® group showed statistically significant differences in all 16 parameters compared to baseline values. Changes in BMI and waist circumference were accompanied by changes in biochemical parameters, with the exception of adiponectin levels which were not correlated to waist circumference and PAI-1 values. The results confirm the hypothesis that Dyglomera®, the aqueous extract of DG, has anti-inflammatory properties, and is effective in reducing cardiovascular disease risk factors associated with metabolic syndrome in obese human subjects. |
| first_indexed | 2024-03-06T15:13:42Z |
| format | Article |
| id | usm.eprints-38333 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:13:42Z |
| publishDate | 2013 |
| publisher | Food Science Publisher |
| record_format | dspace |
| spelling | usm.eprints-383332018-01-10T09:12:41Z http://eprints.usm.my/38333/ Anti-inflammatory, anthropometric and lipomodulatory effects Dyglomera® (aqueous extract of Dichrostachys glomerata) in obese patients with metabolic syndrome Dieudonne, Kuate Blanche C., Etoundi Judith L., Ngondi Wan Muda, Wan Abdul Manan Julius E., Oben TX341-641 Nutrition. Foods and food supply Background: Increased visceral fat, dyslipidemia and increased markers of inflammation and coagulation are cardiovascular risk factors commonly encountered in obese people with metabolic syndrome. Previous studies have shown that ground Dichrostachys glomerata (DG), a spice used in Western Cameroon, can have beneficial effects on inflammation and various other cardiovascular disease risk factors. The purpose of the present study was to evaluate the effects of Dyglomera®, an aqueous extract of DG (standardized to NLT 10% polyphenols) on certain anthropometric, biochemical (including pro-inflammatory and pro-thrombotic states) and hemodynamic parameters in obese patients with metabolic syndrome. Methods: The study was an 8-week randomized, double-blind, placebo-controlled trial involving 116 males and 202 females aged between 24 and 58 years. Participants were randomly divided into two groups: treatment and placebo. Capsules containing the active treatment (200 mg Dyglomera®) or placebo (200 mg maize powder) were administered 30–60 minutes before lunch and dinner throughout the study period. Various biochemical (namely, blood glucose, lipid profile, pro-inflammatory and pro-thrombotic markers), anthropometric and hemodynamic parameters were measured at baseline and after 4 and 8 weeks of treatment.Results: At the end of the study, the Dyglomera® group showed statistically significant differences in all 16 parameters compared to baseline values. Changes in BMI and waist circumference were accompanied by changes in biochemical parameters, with the exception of adiponectin levels which were not correlated to waist circumference and PAI-1 values. The results confirm the hypothesis that Dyglomera®, the aqueous extract of DG, has anti-inflammatory properties, and is effective in reducing cardiovascular disease risk factors associated with metabolic syndrome in obese human subjects. Food Science Publisher 2013 Article PeerReviewed application/pdf en http://eprints.usm.my/38333/1/Anti-inflammatory%2C_anthropometric_and_lipomodulatory_effects.pdf Dieudonne, Kuate and Blanche C., Etoundi and Judith L., Ngondi and Wan Muda, Wan Abdul Manan and Julius E., Oben (2013) Anti-inflammatory, anthropometric and lipomodulatory effects Dyglomera® (aqueous extract of Dichrostachys glomerata) in obese patients with metabolic syndrome. Functional Foods in Health and Disease, 3 (11). pp. 416-427. ISSN 2160-3855 https://www.ffhdj.com/index.php/ffhd/article/view/35/75 |
| spellingShingle | TX341-641 Nutrition. Foods and food supply Dieudonne, Kuate Blanche C., Etoundi Judith L., Ngondi Wan Muda, Wan Abdul Manan Julius E., Oben Anti-inflammatory, anthropometric and lipomodulatory effects Dyglomera® (aqueous extract of Dichrostachys glomerata) in obese patients with metabolic syndrome |
| title | Anti-inflammatory, anthropometric and lipomodulatory effects Dyglomera® (aqueous extract of Dichrostachys glomerata) in obese patients with metabolic syndrome |
| title_full | Anti-inflammatory, anthropometric and lipomodulatory effects Dyglomera® (aqueous extract of Dichrostachys glomerata) in obese patients with metabolic syndrome |
| title_fullStr | Anti-inflammatory, anthropometric and lipomodulatory effects Dyglomera® (aqueous extract of Dichrostachys glomerata) in obese patients with metabolic syndrome |
| title_full_unstemmed | Anti-inflammatory, anthropometric and lipomodulatory effects Dyglomera® (aqueous extract of Dichrostachys glomerata) in obese patients with metabolic syndrome |
| title_short | Anti-inflammatory, anthropometric and lipomodulatory effects Dyglomera® (aqueous extract of Dichrostachys glomerata) in obese patients with metabolic syndrome |
| title_sort | anti inflammatory anthropometric and lipomodulatory effects dyglomera r aqueous extract of dichrostachys glomerata in obese patients with metabolic syndrome |
| topic | TX341-641 Nutrition. Foods and food supply |
| url | http://eprints.usm.my/38333/1/Anti-inflammatory%2C_anthropometric_and_lipomodulatory_effects.pdf |
| work_keys_str_mv | AT dieudonnekuate antiinflammatoryanthropometricandlipomodulatoryeffectsdyglomeraaqueousextractofdichrostachysglomeratainobesepatientswithmetabolicsyndrome AT blanchecetoundi antiinflammatoryanthropometricandlipomodulatoryeffectsdyglomeraaqueousextractofdichrostachysglomeratainobesepatientswithmetabolicsyndrome AT judithlngondi antiinflammatoryanthropometricandlipomodulatoryeffectsdyglomeraaqueousextractofdichrostachysglomeratainobesepatientswithmetabolicsyndrome AT wanmudawanabdulmanan antiinflammatoryanthropometricandlipomodulatoryeffectsdyglomeraaqueousextractofdichrostachysglomeratainobesepatientswithmetabolicsyndrome AT juliuseoben antiinflammatoryanthropometricandlipomodulatoryeffectsdyglomeraaqueousextractofdichrostachysglomeratainobesepatientswithmetabolicsyndrome |