Antiphospholipid syndrome in lupus retinopathy
Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease that can affect any part of the human body including the eyes. Common blinding ocular manifestations include central retinal artery occlusion (CRAO), central retinal vein occlusion (CRVO), severe vaso-occlusive retinopa...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014
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| Online Access: | http://eprints.usm.my/38340/1/Antiphospholipid_syndrome_in_lupus_retinopathy.pdf |
| _version_ | 1825833833572859904 |
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| author | Ng, Hong Kee Chong, Mei Fong Yaakub, Azhany Embong, Zunaina |
| author_facet | Ng, Hong Kee Chong, Mei Fong Yaakub, Azhany Embong, Zunaina |
| author_sort | Ng, Hong Kee |
| collection | USM |
| description | Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease that can affect any part of the human body including the eyes. Common blinding ocular manifestations include central retinal artery occlusion (CRAO), central retinal vein occlusion (CRVO), severe vaso-occlusive retinopathy, and optic nerve involvement. Antiphospholipid syndrome (APS) in lupus is usually associated with large vessel occlusions and needs prompt treatment with anticoagulant. We are reporting two cases of APS in SLE patients that presented with CRVO (case 1) and vaso-occlusive lupus retinopathy (case 2). Both cases were positive for antiphospholipid antibody (APA) and were treated with immunosuppression, anticoagulant, and laser treatment. Thus, screening for APA is vital in SLE patients with lupus retinopathy, as prompt treatment with anticoagulants is important to prevent further vascular thrombosis, which worsens the visual prognosis. |
| first_indexed | 2024-03-06T15:13:43Z |
| format | Article |
| id | usm.eprints-38340 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:13:43Z |
| publishDate | 2014 |
| publisher | Dove Medical Press |
| record_format | dspace |
| spelling | usm.eprints-383402018-01-11T03:59:39Z http://eprints.usm.my/38340/ Antiphospholipid syndrome in lupus retinopathy Ng, Hong Kee Chong, Mei Fong Yaakub, Azhany Embong, Zunaina RE Ophthalmology Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease that can affect any part of the human body including the eyes. Common blinding ocular manifestations include central retinal artery occlusion (CRAO), central retinal vein occlusion (CRVO), severe vaso-occlusive retinopathy, and optic nerve involvement. Antiphospholipid syndrome (APS) in lupus is usually associated with large vessel occlusions and needs prompt treatment with anticoagulant. We are reporting two cases of APS in SLE patients that presented with CRVO (case 1) and vaso-occlusive lupus retinopathy (case 2). Both cases were positive for antiphospholipid antibody (APA) and were treated with immunosuppression, anticoagulant, and laser treatment. Thus, screening for APA is vital in SLE patients with lupus retinopathy, as prompt treatment with anticoagulants is important to prevent further vascular thrombosis, which worsens the visual prognosis. Dove Medical Press 2014-11 Article PeerReviewed application/pdf en http://eprints.usm.my/38340/1/Antiphospholipid_syndrome_in_lupus_retinopathy.pdf Ng, Hong Kee and Chong, Mei Fong and Yaakub, Azhany and Embong, Zunaina (2014) Antiphospholipid syndrome in lupus retinopathy. Clinical Ophthalmology, 2014 (8). pp. 2359-2363. ISSN 1177-5467 http://dx.doi.org/10.2147/OPTH.S71712 |
| spellingShingle | RE Ophthalmology Ng, Hong Kee Chong, Mei Fong Yaakub, Azhany Embong, Zunaina Antiphospholipid syndrome in lupus retinopathy |
| title | Antiphospholipid syndrome in lupus retinopathy |
| title_full | Antiphospholipid syndrome in lupus retinopathy |
| title_fullStr | Antiphospholipid syndrome in lupus retinopathy |
| title_full_unstemmed | Antiphospholipid syndrome in lupus retinopathy |
| title_short | Antiphospholipid syndrome in lupus retinopathy |
| title_sort | antiphospholipid syndrome in lupus retinopathy |
| topic | RE Ophthalmology |
| url | http://eprints.usm.my/38340/1/Antiphospholipid_syndrome_in_lupus_retinopathy.pdf |
| work_keys_str_mv | AT nghongkee antiphospholipidsyndromeinlupusretinopathy AT chongmeifong antiphospholipidsyndromeinlupusretinopathy AT yaakubazhany antiphospholipidsyndromeinlupusretinopathy AT embongzunaina antiphospholipidsyndromeinlupusretinopathy |