| 总结: | Nypa fruticans Wurmb. vinegar, commonly known as nipa palm vinegar (NPV)
has been used as a folklore medicine among the Malay community to treat diabetes. Early
work has shown that aqueous extract (AE) of NPV exerts a potent antihyperglycemic effect.
Thus, this study is conducted to evaluate the effect of AE on postprandial hyperglycemia in
an attempt to understand its mechanism of antidiabetic action. AE were tested via in vitro
intestinal glucose absorption, in vivo carbohydrate tolerance tests and spectrophotometric
enzyme inhibition assays. One mg/mL of AE showed a comparable outcome to the use
of phloridzin (1 mM) in vitro as it delayed glucose absorption through isolated rat jejunum
more effectively than acarbose (1 mg/mL). Further in vivo confirmatory tests showed AE
(500 mg/kg) to cause a significant suppression in postprandial hyperglycemia 30 min
following respective glucose (2 g/kg), sucrose (4 g/kg) and starch (3 g/kg) loadings in normal
rats, compared to the control group. Conversely, in spectrophotometric enzymatic assays, AE
showed rather a weak inhibitory activity against both �-glucosidase and �-amylase when
compared with acarbose. The findings suggested that NPV exerts its anti-diabetic effect by delaying carbohydrate absorption from the small intestine through selective inhibition of
intestinal glucose transporters, therefore suppressing postprandial hyperglycemia.
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