Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates Postprandial Hyperglycemia in Normoglycemic Rats
Nypa fruticans Wurmb. vinegar, commonly known as nipa palm vinegar (NPV) has been used as a folklore medicine among the Malay community to treat diabetes. Early work has shown that aqueous extract (AE) of NPV exerts a potent antihyperglycemic effect. Thus, this study is conducted to evaluate the...
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| Format: | Article |
| Language: | English |
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MDPI
2015
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| Online Access: | http://eprints.usm.my/38360/1/Aqueous_Extract_of_Nypa_fruticans_Wurmb._Vinegar_Alleviates.pdf |
| _version_ | 1825833837371850752 |
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| author | Yusoff, Nor Adlin Ahmad, Mariam Al-Hindi, Bassel Widyawati, Tri Mun, Fei Yam Mahmud, Roziahanim Abdul Razak, Khairul Niza Asmawi, Mohd Zaini |
| author_facet | Yusoff, Nor Adlin Ahmad, Mariam Al-Hindi, Bassel Widyawati, Tri Mun, Fei Yam Mahmud, Roziahanim Abdul Razak, Khairul Niza Asmawi, Mohd Zaini |
| author_sort | Yusoff, Nor Adlin |
| collection | USM |
| description | Nypa fruticans Wurmb. vinegar, commonly known as nipa palm vinegar (NPV)
has been used as a folklore medicine among the Malay community to treat diabetes. Early
work has shown that aqueous extract (AE) of NPV exerts a potent antihyperglycemic effect.
Thus, this study is conducted to evaluate the effect of AE on postprandial hyperglycemia in
an attempt to understand its mechanism of antidiabetic action. AE were tested via in vitro
intestinal glucose absorption, in vivo carbohydrate tolerance tests and spectrophotometric
enzyme inhibition assays. One mg/mL of AE showed a comparable outcome to the use
of phloridzin (1 mM) in vitro as it delayed glucose absorption through isolated rat jejunum
more effectively than acarbose (1 mg/mL). Further in vivo confirmatory tests showed AE
(500 mg/kg) to cause a significant suppression in postprandial hyperglycemia 30 min
following respective glucose (2 g/kg), sucrose (4 g/kg) and starch (3 g/kg) loadings in normal
rats, compared to the control group. Conversely, in spectrophotometric enzymatic assays, AE
showed rather a weak inhibitory activity against both �-glucosidase and �-amylase when
compared with acarbose. The findings suggested that NPV exerts its anti-diabetic effect by delaying carbohydrate absorption from the small intestine through selective inhibition of
intestinal glucose transporters, therefore suppressing postprandial hyperglycemia. |
| first_indexed | 2024-03-06T15:13:47Z |
| format | Article |
| id | usm.eprints-38360 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:13:47Z |
| publishDate | 2015 |
| publisher | MDPI |
| record_format | dspace |
| spelling | usm.eprints-383602018-01-12T08:26:55Z http://eprints.usm.my/38360/ Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates Postprandial Hyperglycemia in Normoglycemic Rats Yusoff, Nor Adlin Ahmad, Mariam Al-Hindi, Bassel Widyawati, Tri Mun, Fei Yam Mahmud, Roziahanim Abdul Razak, Khairul Niza Asmawi, Mohd Zaini RK1-715 Dentistry RS1-441 Pharmacy and materia medica Nypa fruticans Wurmb. vinegar, commonly known as nipa palm vinegar (NPV) has been used as a folklore medicine among the Malay community to treat diabetes. Early work has shown that aqueous extract (AE) of NPV exerts a potent antihyperglycemic effect. Thus, this study is conducted to evaluate the effect of AE on postprandial hyperglycemia in an attempt to understand its mechanism of antidiabetic action. AE were tested via in vitro intestinal glucose absorption, in vivo carbohydrate tolerance tests and spectrophotometric enzyme inhibition assays. One mg/mL of AE showed a comparable outcome to the use of phloridzin (1 mM) in vitro as it delayed glucose absorption through isolated rat jejunum more effectively than acarbose (1 mg/mL). Further in vivo confirmatory tests showed AE (500 mg/kg) to cause a significant suppression in postprandial hyperglycemia 30 min following respective glucose (2 g/kg), sucrose (4 g/kg) and starch (3 g/kg) loadings in normal rats, compared to the control group. Conversely, in spectrophotometric enzymatic assays, AE showed rather a weak inhibitory activity against both �-glucosidase and �-amylase when compared with acarbose. The findings suggested that NPV exerts its anti-diabetic effect by delaying carbohydrate absorption from the small intestine through selective inhibition of intestinal glucose transporters, therefore suppressing postprandial hyperglycemia. MDPI 2015-08 Article PeerReviewed application/pdf en http://eprints.usm.my/38360/1/Aqueous_Extract_of_Nypa_fruticans_Wurmb._Vinegar_Alleviates.pdf Yusoff, Nor Adlin and Ahmad, Mariam and Al-Hindi, Bassel and Widyawati, Tri and Mun, Fei Yam and Mahmud, Roziahanim and Abdul Razak, Khairul Niza and Asmawi, Mohd Zaini (2015) Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates Postprandial Hyperglycemia in Normoglycemic Rats. Nutrients, 7 (8). pp. 7012-7026. ISSN 2072-6643 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555159/ |
| spellingShingle | RK1-715 Dentistry RS1-441 Pharmacy and materia medica Yusoff, Nor Adlin Ahmad, Mariam Al-Hindi, Bassel Widyawati, Tri Mun, Fei Yam Mahmud, Roziahanim Abdul Razak, Khairul Niza Asmawi, Mohd Zaini Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates Postprandial Hyperglycemia in Normoglycemic Rats |
| title | Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates
Postprandial Hyperglycemia in Normoglycemic Rats |
| title_full | Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates
Postprandial Hyperglycemia in Normoglycemic Rats |
| title_fullStr | Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates
Postprandial Hyperglycemia in Normoglycemic Rats |
| title_full_unstemmed | Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates
Postprandial Hyperglycemia in Normoglycemic Rats |
| title_short | Aqueous Extract of Nypa fruticansWurmb. Vinegar Alleviates
Postprandial Hyperglycemia in Normoglycemic Rats |
| title_sort | aqueous extract of nypa fruticanswurmb vinegar alleviates postprandial hyperglycemia in normoglycemic rats |
| topic | RK1-715 Dentistry RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/38360/1/Aqueous_Extract_of_Nypa_fruticans_Wurmb._Vinegar_Alleviates.pdf |
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