Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats
Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptor...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2013
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| Online Access: | http://eprints.usm.my/38379/1/Autonomic_Nervous_System_Mediates_the_Hypotensive_Effects_of_Aqueous_and_Residual.pdf |
| _version_ | 1797010020604313600 |
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| author | Ismail, A. Mohamed, M. Sulaiman, S. A. Wan Ahmad, W. A. N. |
| author_facet | Ismail, A. Mohamed, M. Sulaiman, S. A. Wan Ahmad, W. A. N. |
| author_sort | Ismail, A. |
| collection | USM |
| description | Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This
study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves
and possible involvement of autonomic receptors. AESP and met-AESP (20 to 100mg/kg) were intravenously administered into
anaesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Blood pressure and heart were monitored for
20 min. AESP and met-AESP induced significant dose-dependent hypotension, but only 100mg/kg AESP caused mild bradycardia
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| first_indexed | 2024-03-06T15:13:50Z |
| format | Article |
| id | usm.eprints-38379 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:13:50Z |
| publishDate | 2013 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | usm.eprints-383792018-01-16T01:01:47Z http://eprints.usm.my/38379/ Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats Ismail, A. Mohamed, M. Sulaiman, S. A. Wan Ahmad, W. A. N. QP Physiology RM Therapeutics. Pharmacology Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors. AESP and met-AESP (20 to 100mg/kg) were intravenously administered into anaesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Blood pressure and heart were monitored for 20 min. AESP and met-AESP induced significant dose-dependent hypotension, but only 100mg/kg AESP caused mild bradycardia ( Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://eprints.usm.my/38379/1/Autonomic_Nervous_System_Mediates_the_Hypotensive_Effects_of_Aqueous_and_Residual.pdf Ismail, A. and Mohamed, M. and Sulaiman, S. A. and Wan Ahmad, W. A. N. (2013) Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats. Evidence-Based Complementary and Alternative Medicine, 2013 (716532). pp. 1-16. ISSN 1741-427X http://dx.doi.org/10.1155/2013/716532 |
| spellingShingle | QP Physiology RM Therapeutics. Pharmacology Ismail, A. Mohamed, M. Sulaiman, S. A. Wan Ahmad, W. A. N. Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats |
| title | Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats |
| title_full | Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats |
| title_fullStr | Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats |
| title_full_unstemmed | Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats |
| title_short | Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats |
| title_sort | autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of syzygium polyanthum wight walp var polyanthum leaves in anaesthetized rats |
| topic | QP Physiology RM Therapeutics. Pharmacology |
| url | http://eprints.usm.my/38379/1/Autonomic_Nervous_System_Mediates_the_Hypotensive_Effects_of_Aqueous_and_Residual.pdf |
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