| Summary: | A series of five new 2‐(1‐benzofuran‐2‐yl)‐2‐oxoethyl 4-(un/substituted)benzoates
4(a–e), with the general formula of C8H5O(C=O)CH2O(C=O)C6H4X, X = H, Cl, CH3, OCH3
or NO2, was synthesized in high purity and good yield under mild conditions. The synthesized
products 4(a–e) were characterized by FTIR, 1H-, 13C- and 1H-13C HMQC NMR spectroscopic
analysis and their 3D structures were confirmed by single-crystal X-ray diffraction studies.
These compounds were screened for their antimicrobial and antioxidant activities. The
tested compounds showed antimicrobial ability in the order of 4b < 4a < 4c < 4d < 4e and
the highest potency with minimum inhibition concentration (MIC) value of 125 μg/mL was
observed for 4e. The results of antioxidant activities revealed the highest activity for
compound 4e (32.62% ± 1.34%) in diphenyl-2-picrylhydrazyl (DPPH) radical scavenging,
4d (31.01% ± 4.35%) in ferric reducing antioxidant power (FRAP) assay and 4a (27.11% ±
1.06%) in metal chelating (MC) activity.
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