| Summary: | Stenochlaena palustris fronds are popular as a vegetable in Southeast Asia. The objectives of
this study were to evaluate the anticholinesterase properties and phytochemical profiles of
the young and mature fronds of this plant. Both types of fronds were found to have selective
inhibitory effect against butyrylcholinesterase compared with acetylcholinesterase.
However, different sets of compounds were responsible for their activity. In young fronds,
an antibutyrylcholinesterase effect was observed in the hexane extract, which was
comprised of a variety of aliphatic hydrocarbons, fatty acids, and phytosterols. In the
mature fronds, inhibitory activity was observed in the methanol extract, which contained a
series of kaempferol glycosides. Our results provided novel information concerning the
ability of S. palustris to inhibit cholinesterase and its phytochemical profile. Further
research to investigate the potential use of this plant against Alzheimer's disease is warranted,
however, young and mature fronds should be distinguished due to their phytochemical differences.
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