Cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in Malaysia
Background: Therapeutic drug monitoring (TDM) makes use of serum drug concentrations as an adjunct to decision-making. Preliminary data in our hospital showed that approximately one-fifth of all drugs monitored by TDM service were gentamicin. Objective: In this study, we evaluated the costs as...
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| Format: | Article |
| Language: | English |
| Published: |
Centro de Investigaciones y Publicaciones Farmaceuticas
2014
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| Subjects: | |
| Online Access: | http://eprints.usm.my/38538/1/Cost_evaluation_of_therapeutic_drug_monitoring_of_gentamicin_at_a_teaching_hospital_in_Malaysia.pdf |
| _version_ | 1825833873334861824 |
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| author | Mohamed Ibrahim, Mohamed Izham Ahmed Abdelrahim, Hisham Elhag Ab Rahman, Ab Fatah |
| author_facet | Mohamed Ibrahim, Mohamed Izham Ahmed Abdelrahim, Hisham Elhag Ab Rahman, Ab Fatah |
| author_sort | Mohamed Ibrahim, Mohamed Izham |
| collection | USM |
| description | Background: Therapeutic drug monitoring (TDM) makes
use of serum drug concentrations as an adjunct to
decision-making. Preliminary data in our hospital showed
that approximately one-fifth of all drugs monitored by TDM
service were gentamicin.
Objective: In this study, we evaluated the costs
associated with providing the service in patients with
bronchopneumonia and treated with gentamicin.
Methods: We retrospectively collected data from medical
records of patients admitted to the Hospital Universiti
Sains Malaysia over a 5-year period. These patients were
diagnosed with bronchopneumonia and were on
gentamicin as part of their treatment. Five hospitalisation
costs were calculated; (i) cost of laboratory and clinical
investigations, (ii) cost associated with each gentamicin
dose, (iii) fixed and operating costs of TDM service, (iv)
cost of providing medical care, and (v) cost of hospital stay
during gentamicin treatment.
Results: There were 1920 patients admitted with
bronchopneumonia of which 67 (3.5%) had TDM service
for gentamicin. Seventy-three percent (49/67) patients
were eligible for final analysis. The duration of gentamicin
therapy ranged from 3 to 15 days. The cost of providing
one gentamicin assay was MYR25, and the average cost
of TDM service for each patient was MYR104. The
average total hospitalisation cost during gentamicin
treatment for each patient was MYR442 (1EUR approx.
MYR4.02).
Conclusion: Based on the hospital perspective, in
patients with bronchopneumonia and treated with
gentamicin, the provision of TDM service contributes to
less than 25% of the total cost of hospitalization. |
| first_indexed | 2024-03-06T15:14:18Z |
| format | Article |
| id | usm.eprints-38538 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:14:18Z |
| publishDate | 2014 |
| publisher | Centro de Investigaciones y Publicaciones Farmaceuticas |
| record_format | dspace |
| spelling | usm.eprints-385382018-01-25T02:51:30Z http://eprints.usm.my/38538/ Cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in Malaysia Mohamed Ibrahim, Mohamed Izham Ahmed Abdelrahim, Hisham Elhag Ab Rahman, Ab Fatah RS1-441 Pharmacy and materia medica Background: Therapeutic drug monitoring (TDM) makes use of serum drug concentrations as an adjunct to decision-making. Preliminary data in our hospital showed that approximately one-fifth of all drugs monitored by TDM service were gentamicin. Objective: In this study, we evaluated the costs associated with providing the service in patients with bronchopneumonia and treated with gentamicin. Methods: We retrospectively collected data from medical records of patients admitted to the Hospital Universiti Sains Malaysia over a 5-year period. These patients were diagnosed with bronchopneumonia and were on gentamicin as part of their treatment. Five hospitalisation costs were calculated; (i) cost of laboratory and clinical investigations, (ii) cost associated with each gentamicin dose, (iii) fixed and operating costs of TDM service, (iv) cost of providing medical care, and (v) cost of hospital stay during gentamicin treatment. Results: There were 1920 patients admitted with bronchopneumonia of which 67 (3.5%) had TDM service for gentamicin. Seventy-three percent (49/67) patients were eligible for final analysis. The duration of gentamicin therapy ranged from 3 to 15 days. The cost of providing one gentamicin assay was MYR25, and the average cost of TDM service for each patient was MYR104. The average total hospitalisation cost during gentamicin treatment for each patient was MYR442 (1EUR approx. MYR4.02). Conclusion: Based on the hospital perspective, in patients with bronchopneumonia and treated with gentamicin, the provision of TDM service contributes to less than 25% of the total cost of hospitalization. Centro de Investigaciones y Publicaciones Farmaceuticas 2014-03 Article PeerReviewed application/pdf en http://eprints.usm.my/38538/1/Cost_evaluation_of_therapeutic_drug_monitoring_of_gentamicin_at_a_teaching_hospital_in_Malaysia.pdf Mohamed Ibrahim, Mohamed Izham and Ahmed Abdelrahim, Hisham Elhag and Ab Rahman, Ab Fatah (2014) Cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in Malaysia. Pharmacy Practice, 12 (1). pp. 1-6. ISSN 1886-3655 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955865/ |
| spellingShingle | RS1-441 Pharmacy and materia medica Mohamed Ibrahim, Mohamed Izham Ahmed Abdelrahim, Hisham Elhag Ab Rahman, Ab Fatah Cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in Malaysia |
| title | Cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in Malaysia |
| title_full | Cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in Malaysia |
| title_fullStr | Cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in Malaysia |
| title_full_unstemmed | Cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in Malaysia |
| title_short | Cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in Malaysia |
| title_sort | cost evaluation of therapeutic drug monitoring of gentamicin at a teaching hospital in malaysia |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/38538/1/Cost_evaluation_of_therapeutic_drug_monitoring_of_gentamicin_at_a_teaching_hospital_in_Malaysia.pdf |
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