Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)
Anxiety is a psychological problem that often emerges during the normal course of human life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire. However, these approaches have limitations, as the data might lack reliability and consistency upon application...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2017
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| Online Access: | http://eprints.usm.my/38601/1/Current_and_Potential_Developments_of_Cortisol_Aptasensing.pdf |
| _version_ | 1797010066251972608 |
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| author | Zainol Abidin, Azrul Syafiq A. Rahim, Ruslinda Md Arshad, Mohd Khairuddin Mohd Faudzi, Fatin Nabilah Chun, Hong Voon Tang, Thean Hock Citartan, Marimuthu |
| author_facet | Zainol Abidin, Azrul Syafiq A. Rahim, Ruslinda Md Arshad, Mohd Khairuddin Mohd Faudzi, Fatin Nabilah Chun, Hong Voon Tang, Thean Hock Citartan, Marimuthu |
| author_sort | Zainol Abidin, Azrul Syafiq |
| collection | USM |
| description | Anxiety is a psychological problem that often emerges during the normal course of human
life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire.
However, these approaches have limitations, as the data might lack reliability and consistency upon
application to the same population over time. Furthermore, there might be varying understanding
and interpretations of the particular question by the participant, which necessitating the approach of
using biomarker-based measurement for stress diagnosis. The most prominent biomarker related to
stress, hormone cortisol, plays a key role in the fight-or-flight situation, alters the immune response,
and suppresses the digestive and the reproductive systems. We have taken the endeavour to review
the available aptamer-based biosensor (aptasensor) for cortisol detection. The potential point-of-care
diagnostic strategies that could be harnessed for the aptasensing of cortisol were also envisaged. |
| first_indexed | 2024-03-06T15:14:29Z |
| format | Article |
| id | usm.eprints-38601 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:14:29Z |
| publishDate | 2017 |
| publisher | MDPI |
| record_format | dspace |
| spelling | usm.eprints-386012018-01-30T04:20:56Z http://eprints.usm.my/38601/ Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC) Zainol Abidin, Azrul Syafiq A. Rahim, Ruslinda Md Arshad, Mohd Khairuddin Mohd Faudzi, Fatin Nabilah Chun, Hong Voon Tang, Thean Hock Citartan, Marimuthu RK1-715 Dentistry Anxiety is a psychological problem that often emerges during the normal course of human life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire. However, these approaches have limitations, as the data might lack reliability and consistency upon application to the same population over time. Furthermore, there might be varying understanding and interpretations of the particular question by the participant, which necessitating the approach of using biomarker-based measurement for stress diagnosis. The most prominent biomarker related to stress, hormone cortisol, plays a key role in the fight-or-flight situation, alters the immune response, and suppresses the digestive and the reproductive systems. We have taken the endeavour to review the available aptamer-based biosensor (aptasensor) for cortisol detection. The potential point-of-care diagnostic strategies that could be harnessed for the aptasensing of cortisol were also envisaged. MDPI 2017 Article PeerReviewed application/pdf en http://eprints.usm.my/38601/1/Current_and_Potential_Developments_of_Cortisol_Aptasensing.pdf Zainol Abidin, Azrul Syafiq and A. Rahim, Ruslinda and Md Arshad, Mohd Khairuddin and Mohd Faudzi, Fatin Nabilah and Chun, Hong Voon and Tang, Thean Hock and Citartan, Marimuthu (2017) Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC). Sensors, 17 (5). pp. 1-13. ISSN 1424-8220 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470925/ |
| spellingShingle | RK1-715 Dentistry Zainol Abidin, Azrul Syafiq A. Rahim, Ruslinda Md Arshad, Mohd Khairuddin Mohd Faudzi, Fatin Nabilah Chun, Hong Voon Tang, Thean Hock Citartan, Marimuthu Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC) |
| title | Current and Potential Developments of Cortisol
Aptasensing towards Point-of-Care Diagnostics (POTC) |
| title_full | Current and Potential Developments of Cortisol
Aptasensing towards Point-of-Care Diagnostics (POTC) |
| title_fullStr | Current and Potential Developments of Cortisol
Aptasensing towards Point-of-Care Diagnostics (POTC) |
| title_full_unstemmed | Current and Potential Developments of Cortisol
Aptasensing towards Point-of-Care Diagnostics (POTC) |
| title_short | Current and Potential Developments of Cortisol
Aptasensing towards Point-of-Care Diagnostics (POTC) |
| title_sort | current and potential developments of cortisol aptasensing towards point of care diagnostics potc |
| topic | RK1-715 Dentistry |
| url | http://eprints.usm.my/38601/1/Current_and_Potential_Developments_of_Cortisol_Aptasensing.pdf |
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